CAS: 18635-38-6; Methyl (R)-2-Acetamido-3-Chloropropanoate

相似化合物

7652-46-2 26629-33-4 3619-02-1

上下游产品

CAS号17136-54-8 S-3-氯丝氨酸甲酯盐酸盐 | CAS号75-36-5 乙酰氯 | CAS号2311-26-4 EDTADISODIUM | CAS号35356-70-8 2-乙酰胺基丙烯酸甲酯

N-乙酰-L-丝氨酸甲酯置于五氯化磷体系中,化学反应生成N-乙酰基-3-氯丙氨酸甲酯
参考文献:Teetz; Geiger; Henning,Arzneimittel-Forschung/drug Research,1984,Vol. 34,# 10 B,P. 1399-1401
标题:Teetz; Geiger; Henning,Arzneimittel-Forschung/drug Research,1984,Vol. 34,# 10 B,P. 1399-1401

专利信息

专利号:WO-2005049567-A1
优先权日:2003-11-24
标题:A novel synthesis of 2-azabicyclic-3-carboxylic acids, useful as important drug intermediates
发明人：BABU POTLURI RAMESH; HARIHARAKRISHNAN VENKATA SUBRA; SRIHARI TADIMALLA VENKATA; PRASAD KODALI HARI; RAMESH BETINI; MALLAPARAJU GOTTIMUKKALA VENKA
权利人:BABU POTLURI RAMESH; HARIHARAKRISHNAN VENKATA SUBRA; SRIHARI TADIMALLA VENKATA; PRASAD KODALI HARI; RAMESH BETINI; MALLAPARAJU GOTTIMUKKALA VENKA
摘要:A novel process for the preparation of 2-azabicyclo-3-carboxylic acid hydrochloride of formula (I), by reacting the compound of formula (II) with an acylating agent in a non-polar solvent at 0-150 °C to give a compound of formula (III), which is reacted with an enamine of formula (IV) in a non-polar solvent in the presence of an organic base at 0 °C to 150 °C to yield a compound of formula (V), which is hydrolytically cyclised to give a compound of formula (VI) and further catalytically hydrogenated to give the compound of formula (I).

专利号:EP-1692106-A1
优先权日:2003-11-24
标 题:A novel synthesis of 2-azabicyclic-3-carboxylic acids, useful as important drug intermediates