CAS: 144060-53-7; 2-(3-Cyano-4-Isobutoxyphenyl)-4-Methylthiazole-5-Carboxylic Acid

相似化合物

144060-62-8 1239233-87-4 1239233-86-3

上下游产品

2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester 4-isobutoxyisophthalonitrile 3-cyanoisobutoxybenzothioamide 4-nitrobenzonitrilemethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate iso-butyl ester of febuxostat

4-羟基硫代苯甲酰胺置于盐酸羟胺,水,Potassium Carbonate,三乙胺,Sodium Hydroxide,Magnesium Chloride体系中,用 四氢呋喃,甲醇,N,N-二甲基甲酰胺,乙腈 用作溶剂,化学反应 1.17H,反应生成非布索坦
参考文献:Synthesis,Molecular Docking,Dft Study Of Novel N-Benzyl-2-(3-Cyano-4-Isobutoxyphenyl)-4-Methylthiazole-5-Carboxamide Derivatives And Their Antibacterial Activity
标题:Synthesis,Molecular Docking,Dft Study Of Novel N-Benzyl-2-(3-Cyano-4-Isobutoxyphenyl)-4-Methylthiazole-5-Carboxamide Derivatives And Their Antibacterial Activity
摘要:使用微波方法合成了一系列基于非布索他的新化学实体,并通过核磁共振,质谱和傅里叶变换红外光谱研究进行了表征.非布索他酰胺核取代化合物8C(-7.91Kcal/mol),8G(-7.94 Kcal/mol)的分子对接显示出高结合能对抗alk受体.通过b3Lyp/6-31G方法计算了meps,Homo,Lumo和homo-Lumo能隙的理论研究.在测试的化合物中,甲氧基取代化合物8G对金黄色葡萄球菌和枯草杆菌显示出最高的抗菌活性.
Doi:10.14233/ajchem.2020.22390

专利信息

专利号:US-2021107859-A1
优先权日:2018-04-06
标题 :A process for the synthesis of carbon labeled organic compounds
发明人：AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-2016194279-A1
优先权日:2012-12-09
标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
发明人：CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2024239768-A1
优先权日:2021-04-27
标题 :Method for preparing xanthine oxidase inhibitor
发明人：RYU IN AE; LEE JU YOUNG; YOON JOO YONG; LEE SEOK JU; PARK AH BYEOL; KIM KI DAE; JEONG HUI RAK
权利人:LG CHEMICAL LTD
摘要:The present invention relates to a novel preparation method that can be advantageously utilized for the synthesis of a xanthine oxidase inhibitor of Chemical Formula 1.

专利号:US-2024262809-A1
优先权日:2021-04-27
标题:Method for preparing intermediate for synthesis of xanthine oxidase inhibitor