CAS: 13831-03-3; Tert-Butyl Propiolate

相似化合物

66086-33-7 16889-72-8 79218-15-8

上下游产品

isobutene Propiolic acid acetic acid tert-butyl ester tert-butyl alcoholtert-butyl alcohol-4-(tert-butoxycarbonyl)-7-keto-1,2,7,8,9,10-hexahydroisoquinoline2-(1-phenylsulfonyl)tryptophyl-4-(tert-butoxycarbonyl)-7-keto-1,2,7,8,9,10-hexahydroisoquinoline (E)-3-{[2-(1H-Indol-3-yl)-ethyl]-[5-(2-methyl-[1,3]dioxolan-2-yl)-cyclohexa-1,3-dienylmethyl]-amino}-acrylic acid tert-butyl ester benzene-1,3,5-tricarboxylic acid tri-tert-butyl ester benzene-1,2,4-tricarboxylic acid tri-tert-butyl ester

异丁烯,丙炔酸置于硫酸体系中,用 乙醚 用作溶剂,以74%的收率获得叔丁基丙炔酸酯
参考文献:4-氨基吡咯烷-3-羧酸和4-氨基四氢呋喃-3-羧酸的顺式和反式立体异构体的不对称合成.
标题:4-氨基吡咯烷-3-羧酸和4-氨基四氢呋喃-3-羧酸的顺式和反式立体异构体的不对称合成.
摘要:锂(S)-N-苄基-N-[小α]-甲基苄基酰胺的非对映选择性共轭加成已成功应用于顺式-(3S,4R)-和反式-(3R,4R)-4的首次不对称合成中-氨基四氢呋喃-3-羧酸(总产率分别为26%和25%,Ee分别＞ 98%和ee＞ 97%).此外,描述了迄今为止最有效的不对称合成顺式(3R,4R)-和反式(3R,4S)-4-氨基吡咯烷羧酸:对于顺式(3R,4R),四个步骤,> 98% De,总收率52%;反式(3R,4S)的五个步骤,> 98%de,总收率50%.
Doi:10.1039/b407558G

专利信息

专利号:US-8153839-B2
优先权日:2005-09-14
标题:Method for synthesis of keto acids or amino acids by hydration of acetylene compound
发明人：OGO SEIJI; FUKUZUMI SHUN-ICHI
权利人:OGO SEIJI; FUKUZUMI SHUN-ICHI; JAPAN SCIENCE & TECH AGENCY
摘要:An object of the present invention is to provide a method for synthesis of keto acids by hydration of an acetylene compound (acetylene-carboxylic acids) under mild conditions free from harmful mercury catalysts and a method for synthesis of amino acids from acetylene-carboxylic acids in a single container (one-pot or tandem synthesis). In one embodiment of the method according to the present invention for synthesis of keto acids, acetylene-carboxylic acids is hydrated in the presence of a metal salt represented by General Formula (1), n nwhere M 1 represents an element in Group VIII, IX, or X of the periodic table, and X 1 , X 2 , or X 3 ligand represents halogen, H 2 O, or a solvent molecule, and k represents a valence of a cation species, and Y represents an anion species, and L represents a valence of the anion species, and each of K and L independently represents 1 or 2, and k×m=L×n.

专利号:US-8268936-B2
优先权日:2005-01-04
标题:Synthesis of hybrid block copolymers and uses thereof
发明人：BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.

专利号:US-2012196989-A1
优先权日:2005-02-11
标题:Synthesis of homopolymers and block copolymers
发明人：BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to homopolymers and block copolymers and methods of preparing the same.

专利号:US-8288566-B2
优先权日:2008-11-17
标 题 :Enantioselective synthesis of γ-amino-αβ-unsaturated carboxylic acid derivatives
发明人：ACEMOGLU MURAT; PFALTZ ANDREAS; SCHAERER CLAUDE
权利人:ACEMOGLU MURAT; PFALTZ ANDREAS; SCHAERER CLAUDE; NOVARTIS AG
摘要:Provided is an enantioselective, palladium-catalyzed method for the preparation of γ-amino-α,β-unsaturated carboxylic acid derivatives having the formulas II, III, VII and VIII:

专利号:US-2006172914-A1
优先权日:2005-01-04
标题:Synthesis of hybrid block copolymers and uses thereof

专利号:US-2011124634-A1
优先权日:2008-05-13
标 题:Bioactive compounds for treatment of cancer and neurodegenerative diseases
发明人：SUN CONNIE L; LI XIAOYUAN
权利人:PONIARD PHARMACEUTICALS INC
摘要:The invention provides bioactive compounds for the treatment of various malconditions such as cancer and neurodegenerative diseases including Alzheimer's disease. The chemical compounds as disclosed herein are found to show bioactivity in bioassays related to these conditions. Pharmaceutical compositions, combinations and methods of synthesis are provided, as are methods of using the compound, compositions and combinations in the treatment of the diseases.