专利号:US-2012172336-A2 优先权日:2009-03-19 标 题:Fosfluconazole Derivatives, Synthesis, and Use in Long Acting Formulations 发明人:GONNISSEN YVES; VOORSPOELS JODY 权利人:GONNISSEN YVES; VOORSPOELS JODY; SEPS PHARMA N V 摘要:The invention relates to a compound of formula (1) and the salts, N-oxides, quaternary amines, and stereoisomers thereof, wherein R 1 to R 2 are as defined in the claims. The invention further relates to intermediates and methods for the preparation of the compounds of formula (I). The invention also relates to the compounds of formula (I) for use as a medicament, particularly for the prevention or treatment of fungal infections.
专利号:US-2025082766-A1 优先权日:2022-03-31 标 题 :Treatment of brain tumors by targeting the cholesterol pathway in astrocyes 发明人:MAYO LIOR 权利人:UNIV RAMOT 摘要:A method of treating a brain tumor in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of an agent capable of downregulating activity or expression of a component of the lipid synthesis and/or transportation pathways in an astrocyte in the tumor microenvironment and/or a therapeutically effective amount of a molecule which is associated with lipid uptake by the tumor cells or immune cells in the tumor microenvironment, or a polynucleotide encoding same.
专利号:CA-3019890-A1 优先权日:2016-04-04 标 题:Bioenzymatic synthesis of tetrahydrocannabivarin (thc-v), cannabinol (cbn), and cannabivarin (cbv) and their use as therapeutic agents
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