CAS: 1236-99-3; Levomepromazine Hydrochloride
- 英文名称Levomepromazine Hydrochloride
- 中文名称左美丙嗪盐酸盐
- IUPAC名称(2R)-3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine;hydrochloride
- 其它别名10-(3-Dimethylamino-2-methylpropyl)-2-methoxyphenothiazine hydr°Chloride
- CAS编号1236-99-3
- EINECS号:214-978-3
- FDA UNII编号:42BB1Y2586
- 分子式:C19H24N2OS.ClH分子量:364.93
- 产品CID: 341888
- 同类组份化合物CAS1236-99-3 (HCl)60-99-1 (free base)7104-38-3 (maleate)
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07 & GHS09;
注释: Exclamation mark & Environment - 危险类别急性毒性 类别4(经口)
严重眼刺激 类别2
皮肤致敏 类别1
水生急性毒性 类别1
水生慢性毒性 类别1
水生慢性毒性 类别2 - 警示词Warning(警告)
- 危险描述H302 |吞咽有害.
H319 |造成严重眼刺激.
H317 |可能引起皮肤过敏反应.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响.
H411 |对水生生物有毒并具有长期持续影响. - 防范说明P264-P270-P301+P312-P330-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
欧盟法规
ECHA物质C&L通报REACH预注册合成工艺路线路线简述
海关参考信息
- 2905110000-甲醇
2921440000-二苯胺
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-9925385-A1
优先权日:1997-11-17
标 题:A method of increasing nucleic acid synthesis with ultrasound
发明人：UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID
权利人:IMARX PHARMACEUTICAL CORP
摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Gál GT, May NV, Bombicz P. Crystal structure of levomepromazine maleate. Acta Crystallogr E Crystallogr Commun. 2016 Apr 5;72(Pt 5):612-5. doi: 10.1107/S2056989016004916. eCollection 2016 May 1.
2: Cox L, Darvill E, Dorman S. Levomepromazine for nausea and vomiting in palliative care. Cochrane Database Syst Rev. 2015 Nov 2;(11):CD009420. doi: 10.1002/14651858.CD009420.pub3. Review. doi: 10.1016/j.pharep.2015.04.005. Epub 2015 Apr 23. doi: 10.1016/j.pharep.2014.07.012. Epub 2014 Aug 7. doi: 10.1016/j.bcp.2014.05.005. Epub 2014 May 16. doi: 10.1002/hup.2376. doi: 10.1007/s00134-013-3138-y. Epub 2013 Oct 30. doi: 10.2147/NDT.S50754. Epub 2013 Aug 28.
9: Piñero-Santiago LE, García C, Lhiaubet-Vallet V, Trzcionka J, Oyola R, Torres K, Leguillú J, Miranda MA. Photooxidation mechanism of levomepromazine in different solvents. Photochem Photobiol. 2013 Nov-Dec;89(6):1479-89. doi: 10.1111/php.12147. Epub 2013 Sep 10. doi: 10.1002/14651858.CD009420.pub2. Review. Update in: Cochrane Database Syst Rev. 2015;(11):CD009420. doi: 10.1111/jphp.12001. Epub 2013 Jan 14. doi: 10.1186/1472-684X-12-2.
合成参考文献
摘要:Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales., 155(1029), 1961 []
摘要:Acta Pharmacologica et Toxicologica., 19(87), 1962 []
摘要:Cesko-Slovenska Farmacie., 15(455), 1966
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