CAS: 121602-93-5; 3,4,5-Trifluorobenzoic Acid

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3,4,5-三氟苯甲酸甲酯置于sodium Hydroxide,盐酸体系中,用 甲醇,水 用作溶剂,化学反应 2.0H,反应生成3,4,5-三氟苯甲酸
参考文献:二苯脲衍生物,用于对抗耐甲氧西林和万古霉素的金黄色葡萄球菌.
标题:二苯脲衍生物,用于对抗耐甲氧西林和万古霉素的金黄色葡萄球菌.
摘要:一类新型的二苯基脲被鉴定为具有抗菌谱的新型抗菌支架,该抗菌谱包括高度耐药的葡萄球菌分离株,即耐甲氧西林和耐万古霉素的金黄色葡萄球菌(mrsa和vrsa).从在一侧带有氨基胍官能团且在另一环上带有正丁基部分的铅化合物3开始,制备了几种类似物.考虑到药代动力学参数是结构优化的关键因素,对亲脂性侧链的结构-活性-关系(sar)进行了严格检查,从而发现了环庚氧基类似物21N作为潜在的候选药物.与万古霉素和利奈唑胺相比,该化合物具有几个显着优势,包括针对mrsa的快速杀伤动力学以及靶向并减轻mrsa在免疫细胞(巨噬细胞)内部的负担的能力.此外,使用秀丽隐杆线虫动物模型在体内证实了21N的有效抗mrsa活性.本研究为进一步开发二苯基脲化合物作为潜在的治疗剂提供了基础,以解决细菌对抗生素的耐药性迅速发展的挑战.
Doi:10.1016/j.Ejmech.2017.02.044

专利信息

专利号:US-2011152210-A1
优先权日:2009-12-18
标题 :Polyphenol compounds for inhibiting proteasome and uses thereof
发明人：CHAN TAK-HANG; DOU Q PING
权利人:UNIV MCGILL; UNIV HONG KONG POLYTECHNIC; UNIV WAYNE STATE
摘要:Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for inhibiting proteasomal activity and for treating cancer is also provided.

专利号:CN-109942433-A
优先权日:2019-04-11
标 题 :A kind of chemical synthesis process of 3 ', 4 ', 5 '-three fluoro- 2- aminobphenyls

专利号:US-2014378541-A1
优先权日:2011-06-16
标题 :Synthetic Epigallocatechin Gallate (EGCG) Analogs
发明人：CHAN TAK-HANG; PAMU SREEDHAR; DOU QING PING; CHEN DI
权利人:CHAN TAK-HANG; PAMU SREEDHAR; DOU QING PING; CHEN DI; UNIV WAYNE STATE; UNIV MCGILL; UNIV HONG KONG POLYTECHNIC
摘要:Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for treating cancer and for treating metabolic disorders is also provided.

专利号:CN-115181054-B
优先权日:2022-08-16
标 题 :Synthesis method of 3-benzyl indole compound

专利号:CN-118754797-B
优先权日:2024-06-11
标 题 :Synthesis method of 3,4, 5-trifluoro-bromobenzene

专利号:CN-118754797-A
优先权日:2024-06-11
标 题:Synthesis method of 3,4, 5-trifluoro-bromobenzene