CAS: 1192-28-5; Cyclopentanone Oxime

该化合物是一种多用途化学中间体,其特征是反应性碘和羟基胺功能组,该化合物在有机合成中特别有用,作为制造环球甲基胺衍生物和其他含氮的乙型环氧循环的前体,在受控制条件下的稳定性和选择性反应性使其适合在药品,农用化学品和特殊化学品中应用.循环结构加强了反应控制,便利了复杂分子与高再生选择性合成.建议谨慎处理,因为它对水和空气具有潜在的敏感性.在惰性条件下的适当储存确保了最佳的储存寿命和性能.

结构式图片

相似化合物

3997-89-5 7283-39-8 1136466-93-7

上下游产品

CAS号1003-03-8 环戊胺 | CAS号120-92-3 环戊酮 | CAS号22987-82-2 1-nitr°Cyclopentene | CAS号2562-38-1 硝基环戊烷 | CAS号4901-28-4 N-cyclopentylhy... | CAS号1191-30-6 5-bromopentanal | CAS号3238-17-3 2-chlor°Cyclope... | CAS号142-29-0 环戊烯 | CAS号546-88-3 乙酰氧肟酸 | CAS号111968-95-7 N-(1-phenylsulf... | CAS号31038-06-9 1,1-dichlor°Cyc... | CAS号20667-16-7 Cyclopentanamin... | CAS号1003-03-8 环戊胺 | CAS号675-20-7 2-氮己环酮 | CAS号120-92-3 环戊酮 | CAS号592-51-8 4-戊烯腈 | CAS号110-59-8 戊腈 | CAS号60943-15-9 6-chloro-2,3,4,... | CAS号2562-38-1 硝基环戊烷

合成工艺路线路线简述

    环戊烷 反应 24.0H,反应生成环戊酮肟
    参考文献:Mackor,A.; De Boer,T.J.,Recueil Des Travaux Chimiques Des Pays-Bas,1970,Vol. 89,P. 151-158
    标题:Mackor,A.; De Boer,T.J.,Recueil Des Travaux Chimiques Des Pays-Bas,1970,Vol. 89,P. 151-158

    专利信息


    专利号:US-6770763-B2
    优先权日:2002-06-11
    标题 :Asymmetric synthesis of amino-pyrrolidinones
    发明人:MAGNUS NICHOLAS A; CONFALONE PASQUALE N; SAVAGE SCOTT A; YATES MATTHEW; WALTERMIRE ROBERT E; MELONI DAVID J; CAMPAGNA SILVIO
    权利人:BRISTOL MYERS SQUIBB CO
    摘要:A novel process for the asymmetric synthesis of an amino-pyrrolidinone of the type shown below from appropriate pyrrolidinones is described.These compounds are useful as intermediates for MMP and TACE inhibitors.

    专利号:WO-8911473-A1
    优先权日:1988-05-27
    标 题:Process for the synthesis of o-substituted oxime compounds
    发明人:CHEMPOLIL THOMAS MATHEW
    权利人:ALLIED SIGNAL INC
    摘要:A novel process for the production of O-substituted oximes is disclosed. The process involves reacting an oxime with an alkali-metal hydroxide optionally in a solvent which forms an azeotrope with water to form a mixture of the alkali metal salt of the oxime and water, removing all or a portion of the water by distilling the mixture azeotropically and reacting the distilled mixture with an alpha halo carboxylic acid.

    专利号:US-4365027-A
    优先权日:1981-12-28
    标 题 :Removal of acrylonitrile from latex with oximes
    发明人:SENYEK MICHAEL L; COSTANZA ALBERT J
    权利人:GOODYEAR TIRE & RUBBER
    摘要:Acrylonitrile is a monomer that is widely used in the synthesis of a vast variety of polymers. Undesirable quantities of unpolymerized residual acrylonitrile are often present in these acrylonitrile polymers. This residual or free acrylonitrile dissolved in an acrylonitrile polymer and/or its emulsifier system and the water phase used in its polymerization can be reduced significantly in concentration by treatment with oximes. Oximes react with acrylonitrile by an oxygen-cyanoethylation reaction which results in the formation of a cyanoethyl oximino ether linkage.

    专利号:US-5766887-A
    优先权日:1996-08-26
    标题 :Synthesis of 9-0-acetyl N-acetylneuraminic acid oligosaccharides
    发明人:WONG CHI-HUEY; TAKAYAMA SHUICHI
    权利人:SCRIPPS RESEARCH INST
    摘要:Regioselective acetylation of the 9-hydroxyl group on N-acetylneuraminic acid is achieved enzymatically for producing oligosaccharides which contain a terminal N-acetylneuraminic acid moiety. This method provides access to O-acylated disialogangliosides as well as other N-acetyl-neuraminic acid oligosaccharides. These compounds are biologically and medicinally important and are difficult to obtain from nature or by chemical acylations. The methodology affords simple reaction conditions and minimal purification steps. In addition, the process affords good yields and the enzymes and reagents employed are commercially available with high stability and low costs.

    专利号:US-2003236401-A1
    优先权日:2002-06-11
    标 题:Asymmetric synthesis of amino-pyrrolidinones

    专利号:US-2770643-A
    优先权日:1953-11-05
    标题:Synthesis of aliphatic nitriles by pyrolysis and thermal cleavage of hydrazones, ketazines, ketimines and ketoximes
    发明人:ANDERSON JOHN L
    权利人:DU PONT
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    合成参考文献


    摘要:Kantlehner, W., Science of Synthesis Knowledge Updates, (2014) 4, 359.
    摘要:Chemla, F.; Ferreira, F.; Pérez-Luna, A., Science of Synthesis Knowledge Updates, (2012) 1, 473.
    摘要:Jiao, N.; Li, Z., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 678.
    摘要:Pharmaceutical Chemistry Journal, 12(227), 1978
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