专利号:US-7598291-B2 优先权日:2004-09-02 标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-2010160244-A1 优先权日:2004-09-02 标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-5801192-A 优先权日:1995-08-25 标题 :Use of vitamin C or derivatives or analogues thereof promoting skin elastin synthesis 发明人:DUMAS MARC; BONTE FREDERIC; MEYBECK ALAIN; CHAUDAGNE CATHERINE 权利人:LVMH RECH 摘要:The invention relates to the use of ascorbic acid, notably L-ascorbic acid or vitamin C, or of its erythorbic acid isomer, or of their salts or esters, for promoting the synthesis of elastin in the dermis in the view of improving in particular skin elasticity. n The invention enables manufacturing cosmetic or pharmaceutical compositions, notably dermatological compositions, for improving skin elasticity, for example in the context of a product which improves skin tone or skin firmness. n The invention also enables increasing the elastin content of artificial dermes.
专利号:US-2020123103-A1 优先权日:2017-05-12 标 题 :Method for the synthesis of an n-acyl compound without the use of organic solvent or acid chloride
专利号:EP-3621959-A1 优先权日:2017-05-12 标题 :Method for the synthesis of an n-acyl compound without the use of organic solvent or acid chloride
专利号:CN-1456674-A 优先权日:2002-05-10 标 题 :Catalyzed Synthesis of Lower Alcohol Esters of Fatty Acids by Immobilized Lipase
参考文献:10.1016/j.talanta.2009.09.024 摘要:Ieggli CV, Bohrer D, do Nascimento PC, de Carvalho LM, Garcia SC. Determination of sodium, potassium, calcium, magnesium, zinc, and iron in emulsified egg samples by flame atomic absorption spectrometry. Talanta. 2010 Jan 15;80(3):1282–6. doi: 10.1016/j.talanta.2009.09.024.