CAS: 10231-84-2; (2S,3S,4R,5S,6S)-2-Methyl-6-(4-Nitrophenoxy)Tetrahydro-2H-Pyran-3,4,5-Triol

该化合物是一种合成胶合胶合物,通常用作生物化学鉴定的基质,特别是用于检测focosidase酶.这种化合物具有与-L-focoside modie有关的p-nicoby联苯组,该组系来自Fucose,一种乙氧糖.p-nicobex 组的存在可以进行色度检测;在通过 fuscoids进行酶水解时,释放p-nnicol 的结果可测量色变化,便于定量分析.p-nitroby-L-fucoside 通常是白色的黄色晶粉末,溶于水和有机溶剂,如乙醇和乙醇.在标准的实验室条件下,其稳定性一般良好,尽管应储存在一个冷干的地方防止降解.这种化合物在研究环境中广泛使用,用于研究碳水化合物的代谢和酶活变,使其成为精学和酶学中的宝贵工具.

结构式图片

上下游产品

p-nitrophenyl 2,3,4-tri-O-acetyl-α-L-fucopyranoside 4-nitro-phenol L-fucose tetraacetate 1,2,3,4-tetra-O-acetyl-β-L-fucopyranose p-aminophenyl α-L-fucopyranoside 3-O-α-L-fucopyranosyl-D-glucose 2-Acetamido-2-deoxy-3-O-(α-L-fucopyranosyl)-D-glucopyranose 4-nitro-phenol

合成工艺路线路线简述

    📜对硝基苯酚置于甲醇,Sodium Methylate,Zinc(II) Chloride体系中,化学反应生成4-硝基苯-α-L-吡喃海藻糖苷
    参考文献:Levvy; Mcallan,Biochemical Journal,1961,Vol. 80,P. 433,434,435
    标题:Levvy; Mcallan,Biochemical Journal,1961,Vol. 80,P. 433,434,435

    海关参考信息

    专利信息


    专利号:US-2014228554-A1
    优先权日:2011-03-18
    标 题:Synthesis of new fucose-containing carbohydrate derivatives
    发明人:CHAMPION ELISE; DEKANY GYULA; HEDEROS MARKUS; AGOSTON KAROLY
    权利人:GLYCOM AS; GLYCOM AS
    摘要:A method for the synthesis of a fucooligosaccharide glycosides by reacting a fucosyl donor with H-A-R 1 or a salt thereof, wherein A and R 1 are as defined herein, under the catalysis of an enzyme capable of transferring fucose is provided. The fucooligosaccharid glycoside compounds, or derivatives thereof, their use in the manufacture of human milk oligosaccharides, and a method of manufacture of human milk oligosaccharides, are also provided.

    专利号:US-4918009-A
    优先权日:1985-12-11
    标 题:Method of controlling the regioselectivity of glycosidic bonds
    发明人:NILSSON KURT G I
    权利人:SVENSKA SOCKERFABRIKS AB
    摘要:A method of controlling the regioselectivity of the glycosidic bond between glycosyl donor and glycosyl acceptor in the enzymatic production of an oligosaccharide compound which either consists of or is a fragment or an analog of the cabohydrate part in a glycoconjugate, by reverse hydrolysis or transglycosidation reactions, is described. The synthesis is carried out in that a donor substance which is a mono- or oligosaccharide or a glycoside thereof, is caused to react, in the presence of a glycosidase, with an acceptor substance which is an O-, N-, C- or S-glycoside consisting of a monosaccharide, oligosaccharide or a saccharide analog and at least one aglycon which is O-, N-, C- or S-glycosidically bonded in 1-position, the alpha or beta -configuration being selected on the glycoside bond between the glycosyl group and the aglycon in the acceptor substance, and the oligosaccharide compound being separated from the reaction mixture.

    专利号:US-5096909-A
    优先权日:1989-06-27
    标题 :Fucosidase inhibitor
    发明人:FLEET GEORGE W J; NAMGOONG SUNG K
    权利人:MONSANTO CO
    摘要:The synthesis of the novel fucosidase inhibitor, 2,6-imino-2,6,7-trideoxy-D-glycero-D-gluco heptitol, is disclosed.

    专利号:US-5153325-A
    优先权日:1989-06-27
    标题:Fucosidase inhibitor
    发明人:FLEET GEORGE W J; NAMGOONG SUNG K
    权利人:MONSANTO CO
    摘要:The synthesis of the novel fucosidase inhibitor, 2,6-imino-2,6,7-trideoxy-D-glycero-D-gluco heptitol, is disclosed.

    专利号:US-5017704-A
    优先权日:1989-06-27
    标题 :Fucosidase inhibitor
    发明人:FLEET GEORGE W J; NAMGOONG SUNG K
    权利人:MONSANTO CO
    摘要:The synthesis of the novel fucosidase inhibitor, 2,6-imino-2,6,7-trideoxy-D-glycero-D-gluco heptitol, is disclosed.

    专利号:JP-2014510098-A
    优先权日:2011-03-18
    标题:Synthesis of novel fucose-containing carbohydrate derivatives

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.3390/molecules24132402
    摘要:Escamilla-Lozano Y, Guzmán-Rodríguez F, Alatorre-Santamaría S, García-Garibay M, Gómez-Ruiz L, Rodríguez-Serrano G, Cruz-Guerrero A. Synthesis of Fucosyl-Oligosaccharides Using α-l-Fucosidase from Lactobacillus rhamnosus GG. Molecules. 2019 Jun 29;24(13):2402. doi: 10.3390/molecules24132402.
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