专利号:US-2014228554-A1 优先权日:2011-03-18 标 题:Synthesis of new fucose-containing carbohydrate derivatives 发明人:CHAMPION ELISE; DEKANY GYULA; HEDEROS MARKUS; AGOSTON KAROLY 权利人:GLYCOM AS; GLYCOM AS 摘要:A method for the synthesis of a fucooligosaccharide glycosides by reacting a fucosyl donor with H-A-R 1 or a salt thereof, wherein A and R 1 are as defined herein, under the catalysis of an enzyme capable of transferring fucose is provided. The fucooligosaccharid glycoside compounds, or derivatives thereof, their use in the manufacture of human milk oligosaccharides, and a method of manufacture of human milk oligosaccharides, are also provided.
专利号:US-4918009-A 优先权日:1985-12-11 标 题:Method of controlling the regioselectivity of glycosidic bonds 发明人:NILSSON KURT G I 权利人:SVENSKA SOCKERFABRIKS AB 摘要:A method of controlling the regioselectivity of the glycosidic bond between glycosyl donor and glycosyl acceptor in the enzymatic production of an oligosaccharide compound which either consists of or is a fragment or an analog of the cabohydrate part in a glycoconjugate, by reverse hydrolysis or transglycosidation reactions, is described. The synthesis is carried out in that a donor substance which is a mono- or oligosaccharide or a glycoside thereof, is caused to react, in the presence of a glycosidase, with an acceptor substance which is an O-, N-, C- or S-glycoside consisting of a monosaccharide, oligosaccharide or a saccharide analog and at least one aglycon which is O-, N-, C- or S-glycosidically bonded in 1-position, the alpha or beta -configuration being selected on the glycoside bond between the glycosyl group and the aglycon in the acceptor substance, and the oligosaccharide compound being separated from the reaction mixture.
专利号:US-5096909-A 优先权日:1989-06-27 标题 :Fucosidase inhibitor 发明人:FLEET GEORGE W J; NAMGOONG SUNG K 权利人:MONSANTO CO 摘要:The synthesis of the novel fucosidase inhibitor, 2,6-imino-2,6,7-trideoxy-D-glycero-D-gluco heptitol, is disclosed.
专利号:US-5153325-A 优先权日:1989-06-27 标题:Fucosidase inhibitor 发明人:FLEET GEORGE W J; NAMGOONG SUNG K 权利人:MONSANTO CO 摘要:The synthesis of the novel fucosidase inhibitor, 2,6-imino-2,6,7-trideoxy-D-glycero-D-gluco heptitol, is disclosed.
专利号:US-5017704-A 优先权日:1989-06-27 标题 :Fucosidase inhibitor 发明人:FLEET GEORGE W J; NAMGOONG SUNG K 权利人:MONSANTO CO 摘要:The synthesis of the novel fucosidase inhibitor, 2,6-imino-2,6,7-trideoxy-D-glycero-D-gluco heptitol, is disclosed.
专利号:JP-2014510098-A 优先权日:2011-03-18 标题:Synthesis of novel fucose-containing carbohydrate derivatives
参考文献:10.3390/molecules24132402 摘要:Escamilla-Lozano Y, Guzmán-Rodríguez F, Alatorre-Santamaría S, García-Garibay M, Gómez-Ruiz L, Rodríguez-Serrano G, Cruz-Guerrero A. Synthesis of Fucosyl-Oligosaccharides Using α-l-Fucosidase from Lactobacillus rhamnosus GG. Molecules. 2019 Jun 29;24(13):2402. doi: 10.3390/molecules24132402.