CAS: 91396-88-2; N'-Phenylisonicotinohydrazide
该化合物是一种有机化合物,其特征是附于一个丙烯环上的氢氮功能组,该化合物通常具有分子结构,包括一个苯基组和一个氢氮杂酸,有助于其潜在的反应和生物活动;该化合物经常用于各种化学合成,并可能作为较复杂的分子的前体;环的存在具有某些芳香特性,而水合二苯的功能可参与各种化学反应,例如凝聚和氢合二苯形成.N'苯丙胺-4-碳水合二苯还可能表现出有趣的药理特性,使其成为医药化学的兴趣对象,其溶性与稳定性可能因溶剂和环境条件而不同.与许多有机化合物一样,在处理时应采取安全防范措施,因为如果加入或吸入,可能会对健康造成危害.总的来说,该化合物是有机合成和研究应用中一个多用途的建筑块.
物理性质
- 熔点177-178 °C
- 沸点335.7±15.0 °C at 760 mmHg
- 闪点156.9±20.4 °C
- 密度1.3±0.1 g/cm3
- pKa:10.69±0.23(预测)
- PSA:54.02
- LogP:1.34
- 折射率1.655
- 蒸汽压0.0±0.7 mmHg at 25°C
- 溶解性DMSO: Soluble15mg/mL, Clear
- 外观形态白色至米色粉末
- 储存条件密封干燥,冷冻保存, 低于 -20°C
- 产品应用该化合物是多功能细胞特有抑制器(PLOURISIN) . PLULISIN #1 诱发ER 压力,蛋白合成衰减和 HPSCS 的吸附性. PLORISSIN # 1 也对鼠标爆炸杆有细胞毒性, 表明对幼虫的依赖是多功能状态所固有的. 细胞疗法中使用人类多功能干细胞(HPSC) 受到残余无差异细胞的诱导风险的阻碍.
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
CAS号14254-57-0 异烟酸酰氯 | CAS号100-63-0 苯肼合成工艺路线路线简述
- 14254-57-0 = 91396-88-2
反应条件:1.1 Solvents: Pyridine; 10 Min,0 °C; 8 H,Rt
标题:A Formal [3+2] Cycloaddition Reaction Of N-Methylimidazole As A Masked Hydrogen Cyanide: Access To 1,3-Disubstitued-1H-1,2,4-Triazoles
作者:Yavari,Issa; Et Al
参考文献:Chemical Communications (Cambridge 日期:2020 卷标:56(64) 页码:9150-9153]
14254-57-0 + 59-88-1 = 91396-88-2
反应条件:1.1 Reagents: Pyridine Solvents: Dichloromethane; 0 °C -> Rt
标题:Facile Synthesis Of Fully Substituted 1,2,4-Triazoles Via [3+2] Cycloaddition Of Nitrileimines With Amidine Under Transition Metal-Free Conditions
作者:Wang,Dahan; Et Al
参考文献:Asian Journal Of Organic Chemistry 日期:2023 卷标:12(1)
📜异烟酸酰氯,苯肼置于苯体系中,化学反应生成 4-吡啶羧酸 2-苯基酰肼
参考文献:Chemotherapy Of Experimental Tuberculosis. Viii. The Synthesis Of Acid Hydrazides,Their Derivatives And Related Compounds1,2
标题:Chemotherapy Of Experimental Tuberculosis. Viii. The Synthesis Of Acid Hydrazides,Their Derivatives And Related Compounds1,2
摘要:
DOI:10.1021/ja01104A046
海关参考信息
- 2912110000-甲醛
2933310010-吡啶
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9790483-B2
优先权日:2015-04-09
标 题 :Reagents and methods for esterification
发明人：RAINES RONALD T; MIX KALIE
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Methods and reagents for esterification of biological molecules including proteins, polypeptides and peptides. Diazo compounds of formula I: n nwhere R is hydrogen, an alkyl, an alkenyl or an alkynyl, R A represents 1-5 substituents on the indicated phenyl ring and R M is an organic group, which includes a label, a cell penetrating group, a cell targeting group, or a reactive group or latent reactive group for reaction to bond to a label, a cell penetrating group, or a cell targeting group, among other organic groups are useful for esterification of biological molecules. Also provided are diazo compounds which are bifunctional and trifunctional coupling reagents as well as reagents for the synthesis of compounds of formula I.
专利号:DE-3486043-T2
优先权日:1983-11-18
标 题:INTERMEDIATE CHINOLINE PRODUCTS FOR THE SYNTHESIS OF 1H-IMIDAZO (4,5-C) QUINOLINES AND 1H-IMIDAZO (4,5-C) QUINOLIN-4-AMINES.
专利号:EP-0310950-A1
优先权日:1983-11-18
标 题:Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Ben-David U, Gan QF, Golan-Lev T, Arora P, Yanuka O, Oren YS, Leikin-Frenkel A, Graf M, Garippa R, Boehringer M, Gromo G, Benvenisty N. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell. 2013 Feb 7;12(2):167-79. doi: 10.1016/j.stem.2012.11.015. Epub 2013 Jan 11. V. (2017). GSK3B regulates epithelial-mesenchymal transition and cancer stem cell properties and is a novel drug target for triple-negative breast cancer.
合成参考文献
参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
📝 需求与反馈
尽可能描述清楚需求与问题信息
