CAS: 77-32-7; 2-Mercapto-5,5-Diethyl-1H,5H-Pyrimidine-4,6-Dione

该化合物是硫磺替代环环结构,该化合物在2位置上出现,增加了其在核生殖替代和协调化学中的效用,因此具有明显的反作用.在5位置上的二乙基替代成分有助于消毒和电子调节,影响其溶性与稳定性.其巴氏核心使它成为制药,农用化学或结扎合成的潜在中间体.该化合物的结构特征允许选择性的功能化,在合成应用中提供多功能性.由于对水和光的潜在敏感性,建议进行适当的处理.

结构式图片

MSDS等安全信息

    上下游产品

    5,5-二乙基丙二酰脲 Diethylbarbituric Acid 57-44-3

    合成工艺路线路线简述

      📜二乙基丙二酸二乙酯 反应生成 5,5-二乙基-2-硫代巴比妥酸
      参考文献:Fischer,E.; Dilthey,Justus Liebigs Annalen Der Chemie,1904,Vol. 335,P. 364
      标题:Fischer,E.; Dilthey,Justus Liebigs Annalen Der Chemie,1904,Vol. 335,P. 364

      海关参考信息

      专利信息


      专利号:US-2025002467-A1
      优先权日:2023-06-26
      标题 :Design, synthesis and mechanisms of anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
      发明人:ABDU-ALLAH HAJJAJ H M; RAMADAN WAFAA S; SABER-AYAD MAHA MOHAMED; HAMOUDI RIFAT; AHMED SAMREIN; VENKATACHALAM THENMOZHI; HAFEZI SHIRIN; EL-SHORBAGI ABDEL-NASSER; TARAZI HAMADEH; SOARES NELSON DA CRUZ; SEMREEN MOAHAMMED HARB; EL-AWADY RAFAT
      权利人:UNIV OF SHARJAH
      摘要:Novel 5-Aminosalicylate-4-thiazolinone derivatives for therapeutic formulations and methods for treating cancer. There are provided novel compounds as development of new anti-cancer agents with multicellular targets and with higher selectivity to cancer cells to enhance the outcome of cancer therapy. In a preferred aspect, there is provided a pharmaceutical composition, including a therapeutically effective amount of compound I.A, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutical excipients.

      专利号:US-2008004415-A1
      优先权日:2004-05-03
      标题 :Non-linear optically active molecules, their synthesis, and use
      发明人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
      权利人:OPTIMER PHOTONICS INC
      摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.

      专利号:CA-2312749-A1
      优先权日:1997-12-01
      标 题:Pdgf receptor kinase inhibitory compounds and compositions, method for synthesis of same and use of same for treatment of proliferate disorders

      专利号:WO-0226909-A1
      优先权日:2000-09-29
      标 题 :Compositions and methods for thionation during chemical synthesis reactions
      发明人:CURPHEY THOMAS J
      权利人:DARTMOUTH COLLEGE; CURPHEY THOMAS J
      摘要:Compositions and methods for using these compositions to produce high yields of thionated compounds are provided.

      专利号:US-7012148-B2
      优先权日:2001-09-25
      标题 :Compositions and methods for thionation during chemical synthesis reactions
      发明人:CURPHEY THOMAS J
      权利人:DARTMOUTH COLLEGE
      摘要:Compositions and methods for using these compositions to produce high yields of thionated compounds are provided.

      专利号:TW-I245036-B
      优先权日:2002-09-02
      标题:Synthesis and pharmaceuticals of 1,5-bis-substituted anthraquinones

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      📌 第三方产品分析报告

      ✅ COA系统入驻 | 共享模式

      合成参考文献


      参考文献:10.1007/bf00427228
      摘要:Nemes Z, Dietz R, Mann JFE, Lüth JB, Gross F. Vasoconstriction and increased blood pressure in the development of accelerated vascular disease. Virchows Archiv A Pathological Anatomy and Histopathology. 1980 Apr;386(2):161–73. doi: 10.1007/bf00427228.
      摘要:Journal of Pharmacology and Experimental Therapeutics., 97(478), 1949 []
      参考文献:10.1007/s00401-006-0087-3
      摘要:Pugliese M, Mascort J, Mahy N, Ferrer I. Diffuse beta-amyloid plaques and hyperphosphorylated tau are unrelated processes in aged dogs with behavioral deficits. Acta Neuropathol. 2006 Aug;112(2):175–83. doi: 10.1007/s00401-006-0087-3.
      参考文献:10.1007/bf00640922|10.1007/bf00640923
      摘要:Fabritius J, Nell G, Loeschke K. Adaptation of electrolyte transport in rat large intestine after proximal resection. II. Colon after 50% jejunoilectomy combined with cecectomy. Pflugers Arch. 1986 Mar;406(3):328–32. doi: 10.1007/bf00640923.
      参考文献:10.1007/bf00173201
      摘要:Alberch J, Arenas E, Pérez-Navarro E, Marsal J. Control of tachykinin-evoked acetylcholine release from rat striatal slices by dopaminergic neurons. Naunyn Schmiedebergs Arch Pharmacol. 1993 Nov;348(5):445–9. doi: 10.1007/bf00173201.
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