专利号:US-2025002467-A1 优先权日:2023-06-26 标题 :Design, synthesis and mechanisms of anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives 发明人:ABDU-ALLAH HAJJAJ H M; RAMADAN WAFAA S; SABER-AYAD MAHA MOHAMED; HAMOUDI RIFAT; AHMED SAMREIN; VENKATACHALAM THENMOZHI; HAFEZI SHIRIN; EL-SHORBAGI ABDEL-NASSER; TARAZI HAMADEH; SOARES NELSON DA CRUZ; SEMREEN MOAHAMMED HARB; EL-AWADY RAFAT 权利人:UNIV OF SHARJAH 摘要:Novel 5-Aminosalicylate-4-thiazolinone derivatives for therapeutic formulations and methods for treating cancer. There are provided novel compounds as development of new anti-cancer agents with multicellular targets and with higher selectivity to cancer cells to enhance the outcome of cancer therapy. In a preferred aspect, there is provided a pharmaceutical composition, including a therapeutically effective amount of compound I.A, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutical excipients.
专利号:US-2008004415-A1 优先权日:2004-05-03 标题 :Non-linear optically active molecules, their synthesis, and use 发明人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B 权利人:OPTIMER PHOTONICS INC 摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.
专利号:CA-2312749-A1 优先权日:1997-12-01 标 题:Pdgf receptor kinase inhibitory compounds and compositions, method for synthesis of same and use of same for treatment of proliferate disorders
专利号:WO-0226909-A1 优先权日:2000-09-29 标 题 :Compositions and methods for thionation during chemical synthesis reactions 发明人:CURPHEY THOMAS J 权利人:DARTMOUTH COLLEGE; CURPHEY THOMAS J 摘要:Compositions and methods for using these compositions to produce high yields of thionated compounds are provided.
专利号:US-7012148-B2 优先权日:2001-09-25 标题 :Compositions and methods for thionation during chemical synthesis reactions 发明人:CURPHEY THOMAS J 权利人:DARTMOUTH COLLEGE 摘要:Compositions and methods for using these compositions to produce high yields of thionated compounds are provided.
专利号:TW-I245036-B 优先权日:2002-09-02 标题:Synthesis and pharmaceuticals of 1,5-bis-substituted anthraquinones
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