CAS: 73799-64-1; 3-Azabicyclo[3.1.0]Hexane Hydrochloride

相似化合物

285-59-6 936551-50-7 70110-45-1

📜Tert-Butyl 3-Azabicyclo[3.1.0]Hexane-3-Carboxylate置于盐酸体系中,用 甲醇 作为反应溶剂,以75%的收率获得产物3-氮杂双环[3.1.0]己烷盐酸盐
参考文献:一种3-氮杂双环[3.1.0]己烷盐酸盐的制备方 法
标题:一种3-氮杂双环[3.1.0]己烷盐酸盐的制备方 法
摘要:本发明公开了一种3‑氮杂双环[3.1.0]己烷盐酸盐的制备方法,它以化合物ii为原料,与乙酸溶液和锌粉在加热的条件下反应,得到包含化合物iii的反应液,再用碱处理,得到包含化合物iv的处理液,再与氯化氢气体反应,得到3‑氮杂双环[3.1.0]己烷盐酸盐.与现有技术相比,本发明制备工艺简单,反应条件温和且成本较低.同时,本发明制备工艺的总收率可达71%.

专利信息

专利号:US-11512097-B2
优先权日:2019-11-25
标题 :Heterocyclic compounds as Delta-5 desaturase inhibitors and methods of use
发明人：ALLEN JENNIFER R; BELTRANI MICHELA; BOURBEAU MATTHEW P; DAMYANOVA TEODORA P; LINGARD IAIN; MINATTI ANA E; VINCETTI PAOLO
权利人:AMGEN INC
摘要:The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5D†). The compounds have a general Formula I n nwherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-2024383853-A1
优先权日:2021-09-28
标题:Oximes and their use in treatment of gba-related diseases
发明人：NEVE SØREN; BROWN WILLIAM DALBY; THIRSTRUP KENNETH
权利人:ZEVRA DENMARK AS
摘要:The present invention relates to oximes, their synthesis, and their use for increasing GBA activity and/or levels as well as treatment of GBA-related diseases, such as Parkinson's disease.