CAS: 7022-45-9; 2-(Methylthio)Benzaldehyde

该化合物是一种含有芳烃的硫磺,配有分子式C8H8OS.该化合物具有甲基硫(-SCH3)替代物,位于苯并丁环的正方形位置,在有机合成中具有独特的回活动和应用作用.该化合物是制作药品,农用化学品和特殊化学品,特别是乙基环和硫基化合物合成的多用途中间体.甲基硫化合物组会增强电子密度,影响核循环添加或凝聚等反应中的再生选择性.其独特的结构特性使得它对于构建复杂的分子框架很有价值.该化合物通常以显色的黄色液体提供,具有典型的气味,需要以惰性条件储存以维持稳定性.

结构式图片

上下游产品

CAS号33384-77-9 (2-甲基磺酰基苯基)-甲醇 | CAS号74-93-1 甲硫醇 | CAS号446-52-6 邻氟苯甲醛 | CAS号92580-60-4 Benzoicacid, 2-... | CAS号89-98-5 邻氯苯甲醛 | CAS号5188-07-8 甲硫醇钠 | CAS号77418-23-6 2-(Methylthio)t... | CAS号1442-03-1 2-methylsulfany... | CAS号885949-42-8 2-(METHYLSULFAN... | CAS号3724-10-5 2-甲硫基苯甲酸 | CAS号30439-35-1 1-methylsulfany... | CAS号30439-34-0 1-ethenyl-2-met... | CAS号5395-89-1 2-甲砜基苯甲醛 | CAS号6008-36-2 壬基酰苯 | CAS号6314-28-9 苯并噻吩-2-羧酸 | CAS号55219-11-9 2-氰基苯并噻吩 | CAS号3724-10-5 2-甲硫基苯甲酸 | CAS号35717-55-6 1-(2-methylsulf... | CAS号33384-77-9 (2-甲基磺酰基苯基)-甲醇 | CAS号22913-24-2 甲基苯并噻吩-2-甲醛

合成工艺路线路线简述

  • 合成目标产物 2-(Methylthio) Benzaldehyde 主要起始原料 Dimethyl Sulfoxide And 2-Bromobenzaldehyde
  • (文献来源)合成步骤主要原料 Dimethyl Sulfoxide 和 2-Bromobenzaldehyde
N'-P-Toluolsulfonyl-N-<2-Methylmercapto-Benzoyl>-Hydrazin置于sodium Carbonate体系中,用 二乙二醇 作为反应溶剂,化学反应生成 邻甲硫基苯甲醛
参考文献:致癌性芳基胺的新硫代衍生物.5.环取代的甲硫基-4-乙酰氨基苯甲酸酯.
标题:致癌性芳基胺的新硫代衍生物.5.环取代的甲硫基-4-乙酰氨基苯甲酸酯.
摘要:
DOI:10.1021/jm00293A023

海关参考信息

专利信息


专利号:US-6514997-B2
优先权日:1999-12-03
标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人:DRAGOVICH PETER S; PRINS THOMAS J; ZHOU RU; JOHNNSON JR THEODORE O
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of the formula: n where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-4172890-A
优先权日:1977-04-01
标 题 :2,3,4,5-Tetrahydro-1H-3-benzazepine-7,8-diones
发明人:HOLDEN KENNETH G
权利人:SMITHKLINE CORP
摘要:Novel benzazepine derivatives having central and peripheral dopaminergic activity useful in treating Parkinson's and cardiovascular diseases. The compounds have additional use as intermediates for the synthesis of other benzazepines with similar useful properties. The 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-dione derivatives are particularly useful.

专利号:US-4108989-A
优先权日:1977-04-01
标 题 :2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones
发明人:HOLDEN KENNETH GEORGE
权利人:SMITHKLINE CORP
摘要:Novel benzazepine derivatives having central and peripheral dopaminergic activity useful in treating Parkinson's and cardiovascular diseases. The compounds have additional use as intermediates for the synthesis of other benzazepines with similar useful properties. The 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-dione derivatives are particularly useful.

专利号:EP-1150949-B1
优先权日:1999-02-10
标题 :Synthesis of mercapto-benzaldehydes

专利号:WO-2009040755-A2
优先权日:2007-09-26
标 题 :Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof ans intermediates thereto

专利号:US-9522901-B2
优先权日:2005-05-26
标题:Compositions and methods including cell death inducers and procaspase activation
发明人:HERGENROTHER PAUL J; PUTT KARSON S; PETERSON QUINN P; FAKO VALERIE
权利人:UNIV ILLINOIS
摘要:Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.
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✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Rhodium-Catalyzed Synthesis Of Amides From Aldehydes And Azides By Chelation-Assisted Ch Bond Activation
作者:Bing Zhou,Yaxi Yang,Jingjing Shi,Huijin Feng,Yuanchao Li |发布日期:2013.8.5
摘要:Ch Activation: A Rhiii‐catalyzed Direct Aldehyde Ch Amidation Has Been Achieved With Sulfonyl, Aryl, And Alkyl Azides As The Amine Sources, And Release Of N2 As The Only Byproduct (See Scheme). More Importantly, This Catalytic Reaction Proceeds In The Absence Of External Oxidants Or Additives, Under Mild Conditions, At Neutral Ph Under Air. This Reaction Represents A New Avenue For Practical Intermolecular

合成参考文献


摘要:Singh, F. V.; Wirth, T., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 29.
摘要:Hafeman, N. J.; Sardini, S. R., Jr.; Bhat, V.; Stoltz, B. M., Science of Synthesis, (2022) , 306.
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