专利号:US-6514997-B2 优先权日:1999-12-03 标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis 发明人:DRAGOVICH PETER S; PRINS THOMAS J; ZHOU RU; JOHNNSON JR THEODORE O 权利人:AGOURON PHARMA 摘要:Compounds of the formula: n where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of the formula: n where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.
专利号:US-4172890-A 优先权日:1977-04-01 标 题 :2,3,4,5-Tetrahydro-1H-3-benzazepine-7,8-diones 发明人:HOLDEN KENNETH G 权利人:SMITHKLINE CORP 摘要:Novel benzazepine derivatives having central and peripheral dopaminergic activity useful in treating Parkinson's and cardiovascular diseases. The compounds have additional use as intermediates for the synthesis of other benzazepines with similar useful properties. The 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-dione derivatives are particularly useful.
专利号:US-4108989-A 优先权日:1977-04-01 标 题 :2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones 发明人:HOLDEN KENNETH GEORGE 权利人:SMITHKLINE CORP 摘要:Novel benzazepine derivatives having central and peripheral dopaminergic activity useful in treating Parkinson's and cardiovascular diseases. The compounds have additional use as intermediates for the synthesis of other benzazepines with similar useful properties. The 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-dione derivatives are particularly useful.
专利号:EP-1150949-B1 优先权日:1999-02-10 标题 :Synthesis of mercapto-benzaldehydes
专利号:WO-2009040755-A2 优先权日:2007-09-26 标 题 :Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof ans intermediates thereto
专利号:US-9522901-B2 优先权日:2005-05-26 标题:Compositions and methods including cell death inducers and procaspase activation 发明人:HERGENROTHER PAUL J; PUTT KARSON S; PETERSON QUINN P; FAKO VALERIE 权利人:UNIV ILLINOIS 摘要:Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.
参考标题:Rhodium-Catalyzed Synthesis Of Amides From Aldehydes And Azides By Chelation-Assisted Ch Bond Activation 作者:Bing Zhou,Yaxi Yang,Jingjing Shi,Huijin Feng,Yuanchao Li |发布日期:2013.8.5 摘要:Ch Activation: A Rhiii‐catalyzed Direct Aldehyde Ch Amidation Has Been Achieved With Sulfonyl, Aryl, And Alkyl Azides As The Amine Sources, And Release Of N2 As The Only Byproduct (See Scheme). More Importantly, This Catalytic Reaction Proceeds In The Absence Of External Oxidants Or Additives, Under Mild Conditions, At Neutral Ph Under Air. This Reaction Represents A New Avenue For Practical Intermolecular
合成参考文献
摘要:Singh, F. V.; Wirth, T., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 29. 摘要:Hafeman, N. J.; Sardini, S. R., Jr.; Bhat, V.; Stoltz, B. M., Science of Synthesis, (2022) , 306.