专利号:WO-9961509-B1 优先权日:1998-05-21 标题:Synthesis of semi-crystalline polyphthalamides through reactive extrusion of hexamethylene terephthalamide oligomer with lower melting, semi-crystalline or amorphous polyamides 发明人:LEBOEUF CHRISTIAN; HARBOURNE DAVID ALAN 权利人:LEBOEUF CHRISTIAN; HARBOURNE DAVID ALAN 摘要:This invention relates to the synthesis of semi-crystalline polyphthalamides (i.e. containing monomeric units of terephthalic acid and hexamethylene diamine) through reactive extrusion of hexamethylene terephthalamide oligomer, or the oligomer of another 6T-rich copolymer, with lower melting semi-crystalline or amorphous polyamides. This process is particularly useful since it is centered around the use of stirred autoclaves for the synthesis of the 6T oligomer and the semi-crystalline or amorphous polyamides which are subsequently combined in a twin screw extruder equipped for devolatilization of water of reaction. It can also be used for the modification of existing semi-crystalline or amorphous polyamides (not necessarily phthalamides) with low levels of 6T.
专利号:US-5258292-A 优先权日:1990-11-28 标题:Enzymic process for the synthesis of ammonium adipate 发明人:YEH PATRICE; MAYAUX JEAN-FRANCOIS; CERBELAUD EDITH; PETRE DOMINIQUE 权利人:RHONE POULENC CHIMIE 摘要:The invention relates to an enzymic process for the synthesis of ammonium adipate by the hydrolysis of adipamide and/or ammonium adipamate by means of a particular polypeptide or a recombinant microorganism generating this polypeptide.
专利号:US-2014234364-A1 优先权日:2011-09-23 标 题:Total synthesis and immunological evaluation of saccharide moieties of the lipopolysaccharide from neisseria meningitidis 发明人:SEEBERGER PETER H; YANG YOU; ANISH CHAKKUMKAL; REINHARDT ANIKA 权利人:MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFTEN E V 摘要:The present invention relates to the total chemical synthesis of the monosaccharide 35 # (R′â•?H), the disaccharide 36 # (R′≠H; R″â•?H), the trisaccharide 37 # (R′≠H; R″≠H; R′″≠H) and the tetrasaccharide 1 # (R′≠H; R″≠H; R′″≠H) of the following general formula wherein R represents —Y—NH 2 Y represents a linker R′ is H or R″ is H or R′″ is H or of the lipopolysaccharide from Neisseria meningitidis , as well as to the trisaccharide 37 # and the tetrasaccharide 1 # , to vaccines containing at least one of the saccharides 1 # , 35 # , 36 # , and 37 # and to the use of such vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide α-GlcNAc-(1→2)-α-Hep-( 1→3 )-α-Hep-(1→5)-α-Kdo or the trisaccharide α-Hep-(1→3)-α-Hep-(1→5)-α-Kdo or α-GlcNAc-(1→2)-±-Hep-(1→3)-α-Hep, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.
专利号:US-5627257-A 优先权日:1994-05-27 标题 :Process for the production of polyamides on the basis of α,ω-dinitriles 发明人:LIEHR HARTMUT 权利人:ZIMMER AG 摘要:Process for synthesis of spinnable polyamide from α, ω-alkyldinitriles and α, ω-alkyldiamines and excess water, where a) the aqueous solution of the dinitrile is mixed with a catalytic amount of at least one oxygen-containing acid of phosphorus and/or a water-soluble salt of calcium, zinc, cadmium or manganese in the absence of the diamine, and the pH of this solution is adjusted to an initial value in the range of 2.0 to 4.0 before hydrolysis by adding a saturated aliphatic or aromatic dicarboxylic acid and the dinitrile is and the amide-containing precursors derived therefrom are hydrolyzed to dicarboxylic acid at an elevated temperature under autogenous pressure, whereby the hydrolysis is controlled by conductometric determination of the hydrolysate, and b) at least an equimolar amount of diamine is added to the solution from step a) and the mixture is subjected to polycondensation to form polyamide [nylon].
专利号:WO-2024039293-A1 优先权日:2022-08-18 标 题:Synthesis of hexamethylenediamine and adipic acid via homocoupling of acrylamides 发明人:LU YIXIN; WU JIE; WU ZUGEN 权利人:NAT UNIV SINGAPORE 摘要:The present disclosure relates to a method of synthesising hexamethylenediamine and adipic acid. The method comprises homocoupling of acrylamide under conditions including using oxalic acid as a reductant and irradiating a reaction mixture comprising acrylamide with light from a light source to obtain an amide substrate, wherein the method further comprises a pathway 1 and a pathway 2 for forming hexamethylenediamine and adipic acid, respectively using the amide substrate.
专利号:US-6689919-B1 优先权日:1999-09-22 标 题 :Catalysts for oxidative polymerization of fluorophenol, method of oxidative polymerization of fluorophenol, and poly(oxyfluorophenylene) derivative 发明人:TSUCHIDA EISHUN; OYAIZU KENICHI; KUMAKI YOSUKE; SAITO KEI 权利人:JAPAN SCIENCE & TECH CORP 摘要:The synthesis of fluoropolyarylene ether with a high degree of polymerization is enabled, by using a copper complex catalyst with an oxidation potential in the range of -1V to 2V, for the oxidative polymerization of fluorophenols that contain at least one hydrogen atom as well as a fluorine atom bonded to the carbon atoms constituting the benzene ring.
[参考文献]: D L Morris, Et Al. The Preparation Of Nylon-Tube-Supported Hexokinase And Glucose 6-Phosphate Dehydrogenase And The Use Of The Co-Immobilized Enzymes In The Automated Determination Of Glucose. Biochem J. 1975 Jun;147(3):593-603. [参考文献]: R W Fleischman, Et Al. Carcinogenesis Bioassay Of Acetamide, Hexanamide, Adipamide, Urea And P-Tolylurea In Mice And Rats. J Environ Pathol Toxicol. 1980 Jun-Jul;3(5-6):149-70. [参考文献]: S J Kennel, Et Al. Monoclonal Antibodies To Chlorinated Dibenzo-P-Dioxins. Toxicol Appl Pharmacol. 1986 Feb;82(2):256-63. [参考文献]: Xuejiang Wang, Et Al. Development Of Biomimetic Nano-Hydroxyapatite/poly(Hexamethylene Adipamide) Composites. Biomaterials. 2002 Dec;23(24):4787-91.
合成参考文献
摘要:Biochemical Journal., 34(1196), 1940 参考文献:10.1021/ol035954j 摘要:Chang SY, Kim HS, Chang KJ, Jeong KS. Efficient modulation of hydrogen-bonding interactions by remote substituents. Org Lett. 2004 Jan 22;6(2):181–4. doi: 10.1021/ol035954j.