CAS: 615-20-3; 2-Chlorobenzothiazole

上下游产品

1,3-Benzothiazole 2-amino-benzthiazole 2(3H)-Benzothiazolone 2-thioxo-3H-1,3-benzothiazole 2-(piperidin-1-yl)benzo[d]thiazole 2-thioxo-3H-1,3-benzothiazole (4-benzothiazol-2-ylamino-phenyl)-arsonic acid N-methyl-N-(p-tolyl)benzo[d]thiazol-2-amine

苯并噻唑置于正丁基锂,三氯乙酸酐体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 0.5H,以95%的收率获得产物2-氯苯并噻唑
参考文献:通过三氯乙酰基衍生物与杂芳族锂和格氏试剂之间的金属卤素交换新合成氯杂环
标题:通过三氯乙酰基衍生物与杂芳族锂和格氏试剂之间的金属卤素交换新合成氯杂环
摘要:芳族氮杂杂环的2-Lithio衍生物与三氯乙酰基衍生物之间的反应通过金属-卤素交换机理快速高产地产生了相应的2-氯衍生物.与用三氯乙酰氯得到的三氯乙酸乙酯相比,使用三氯乙酸乙酯可以得到更好的结果,三氯乙酰氯可能涉及二氯乙烯的形成.与格氏试剂的反应更加复杂:实际上,2-苯并噻唑基氯化镁与三氯乙酸乙酯或三氯乙酰氯的反应分别反应生成2-氯苯并噻唑和大量的1,3-苯并噻唑-2-羧酸乙酯或2-苯并噻唑基二氯甲基酮.
DOI:10.1016/s0022-328X(99)00363-0

专利信息

专利号:US-6159673-A
优先权日:1996-07-17
标 题:Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound
发明人：NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which Z is an atomic group that forms a cyclic amide ring; each of W1 and W2 independently is an atomic group that forms an acidic nucleus ring; and M is a cation. Other oxonol compounds, a light-sensitive material containing an oxonol compound and a process for the synthesis of an oxonol compound are also disclosed.

专利号:EP-1473330-B1
优先权日:1996-07-17
标题:Process for the synthesis of oxonol compound
发明人：NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which each of Z, W<1> and W<2> independently is an atomic group that forms a heterocyclic ring; and M is a cation. A process for the synthesis of an oxonol compound is disclosed.

专利号:US-2023399302-A1
优先权日:2020-10-29
标题:Process for the preparation of heteroaryl-substituted sulfur(vi) compounds
发明人：LOPCHUK JUSTIN M; SHULTZ ZACHARY P; SCATTOLIN THOMAS
权利人:H LEE MOFFITT CANCER CT & RES
摘要:The present disclosure provides processes for the synthesis of organic compounds, in particular processes for the synthesis of heteroaryl-substituted sulfur(VI) compounds by nucleophilic aromatic substitution.

专利号:US-2023407293-A1
优先权日:2021-10-27
标 题:Dna-encoded and affinity-tagged masked-warhead compounds and use thereof in assembling libraries of small molecules enabled for late-stage purification and multiplexed screening of covalent ligands
发明人：MAIANTI JUAN PABLO
权利人:MAIANTI JUAN PABLO
摘要:The present disclosure relates to DNA-encoded and affinity-tagged masked warhead installation compounds and use thereof in the synthesis of electrophilic warhead DNA-Encoded Libraries (eDEL), including substituted and unsubstituted acrylamide warheads, which can be purified from unreacted library intermediates and byproducts.

专利号:US-3558614-A
优先权日:1967-09-05
标题:Synthesis of tetranuclear dyes
发明人：JENKINS PHILIP W
权利人:EASTMAN KODAK CO
摘要:TETRANUCLEAR DYES DERIVED FROM A 2-IMIDAZOLIN-4-ONE, A 2-IMIDAZOLIN-4-THIONE AND A 2-IMIDAZOLIN-4-SELENONE ARE PREPARED IN GOOD YIELDS BY CONDENSING A QUATERNIZED MEROCYANINE DYE DERIVED FROM A 2-IMIDAZOLIN-4-ONE, A 2-IMIDAZOLIN-4-THIONE OR A 2-IMIDAZOLIN4-SELENONE WITH (1) A DIALKOXYALKYL ESTER OF AN ORGANIC ACID, (2) A TRIALKOXY ALKANE OR ARYL COMPOUND, (3) A 3,3-DIALKOZY-1ALKOXYPROPENE, (4) A 1-ANILINO-5-PHENYLIMINO-1,3-PENTADIENE OR (5) A SECOND QUATERNIZED MROCYANINE DYE DERIVED FROM A 2-IMIDAZOLIN-4-ONE, A 2-IMIDAZOLIN-4THIONE OR A 2-IMIDAZOLIN-4-SELENONE, EACH HAVING SUBSTITUTED ON THE CARBON IN THE 2-POSITION A GROUP SUCH AS A B-ACETANILIDOVINYL GROUP, A 4-ACETANILIDO-1,3-BUTADIENYL GROUP, AND A 6-ACETANILIDO-1,3,5-HEXADIENYL GROUP.

专利号:US-8618314-B2
优先权日:2005-01-14
标 题 :Exo- and diastereo-selective synthesis of himbacine analogs
发明人：WU GEORGE G; SUDHAKAR ANANTHA; WANG TAO; XIE JI; CHEN FRANK X; POIRIER MARC; HUANG MINGSHENG; SABESAN VIJAY; KWOK DAW-LONG; CUI JIAN; YANG XIAOJING; THIRUVENGADAM TIRUVETTIPURAM K; LIAO JING; ZAVIALOV ILIA; NGUYEN HOA N; LIM NGIAP KIE
权利人:WU GEORGE G; SUDHAKAR ANANTHA; WANG TAO; XIE JI; CHEN FRANK X; POIRIER MARC; HUANG MINGSHENG; SABESAN VIJAY; KWOK DAW-LONG; CUI JIAN; YANG XIAOJING; THIRUVENGADAM TIRUVETTIPURAM K; LIAO JING; ZAVIALOV ILIA; NGUYEN HOA N; LIM NGIAP KIE; MERCK SHARP & DOHME
摘要:This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following: