CAS: 61478-28-2; (S,S)-Bppm

上下游产品

chloro-diphenylphosphine p-toluenesulfonyl chloride pyrrolidine(2S,4S)-N-(tert-butoxycarbonyl)-4-(p-toluenesulfonyloxy)-2-(p-toluenesulfonyloxy)methylpyrrolidine diphenylphosphane (2S,4S)-4-(diphenylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidine (2S,3S)-N-(t-butoxycarbonyl)-4-diphenylphosphinyl-2-diphenylphosphinylmethylpyrrolidine (2S,3S)-4-dicyclohexylphosphinyl-2-dicyclohexylphosphinylmethylpyrrolidine -1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester(2S-cis)-4-(dicyclohexylphosphino)-2-(dicyclohexylphosphino)methyl-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester

📜(4R)-4-羟基-L-脯氨酸盐酸盐置于lithium Aluminium Tetrahydride,氨,Sodium,三乙胺体系中,用 四氢呋喃,1,4-二氧六环,吡啶,水 作为反应溶剂,化学反应 49.5H,反应生成 (2S,4S)-4-二苯基膦-2-(二苯基膦甲基)-N-叔丁氧羰基-吡咯烷
参考文献:Transition-Metal-Catalyzed Asymmetric Organic Synthesis Via Polymer-Attached Optically Active Phosphine Ligands. 5. Preparation Of Amino Acids In High Optical Yield Via Catalytic Hydrogenation
标题:Transition-Metal-Catalyzed Asymmetric Organic Synthesis Via Polymer-Attached Optically Active Phosphine Ligands. 5. Preparation Of Amino Acids In High Optical Yield Via Catalytic Hydrogenation
摘要:
DOI:10.1021/jo00327A023

专利信息

专利号:US-4879389-A
优先权日:1986-06-25
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人：ACHIWA KAZUO
权利人:ACHIWA KAZUO
摘要:New chiral phosphinopyrrolidine compounds of the general formula: (I) or (I') wherein R1 is a hydrogen atom, -COR, -COOR, -CONHR or -SO2-R where R is an alkyl or aryl group, R2 and R3 each represents independently an aryl group which may have a substituent or substituents, and R4 and R5 each represents independently an aliphatic or cycloaliphatic hydrocarbyl group which may have a substituent or substituents, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

专利号:US-4985567-A
优先权日:1988-03-07
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人：ACHIWA KAZUO; TAKEDA HIDEO
权利人:KAZUO ACHIWA; FUJI YAKUHIN KOGYO KK
摘要:New chiral phosphinopyrrolidine compounds of the general formula: ##STR1## wherein R 1 is hydrogen or --COA 1 , --COOA 2 , --CONHA 3 , --SO 2 A 4 or --PO(A 5 ) 2 , A 1 , A 2 , A 3 , A 4 and A 5 each represents independently alkyl or aryl, R 2 is phenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, and R 3 is phenyl, lower-alkylphenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, with the proviso that R 2 and R 3 may not simultaneously by phenyl, p-di(lower-alkyl)-aminophenyl or p-lower-alkoxyphenyl, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

专利号:US-10745354-B2
优先权日:2017-11-01
标题 :Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
发明人：STOLTZ BRIAN M; NGAMNITHIPORN AURAPAT; JETTE CARINA I; BACHMAN SHOSHANA; VIRGIL SCOTT C; LACKNER SEBASTIAN
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic α-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.

专利号:US-6380416-B2
优先权日:1997-06-13
标题:Asymmetric synthesis catalyzed by transition metal complexes with rigid chiral ligands
发明人：ZHANG XUMU
权利人:PENN STATE RES FOUND
摘要:This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.

专利号:EP-1030854-B1
优先权日:1997-11-12
标题 :Catalysts for asymmetric synthesis containing rigid chiral ligands
发明人：ZHANG XUMU
权利人:PENN STATE RES FOUND
摘要:This invention is to develop novel transition metal catalysts for the pratical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.

专利号:US-5684185-A
优先权日:1992-10-01
标题 :Process for the stereoselective synthesis of 3-substituted 2-sulfonylmethylpropionic acids, and intermediate products
发明人：BECK GERHARD; JENDRALLA JOACHIM-HEINER; KAMMERMEIER BERNHARD
权利人:HOECHST AG
摘要:Compounds of the formula I ##STR1## can be prepared in a multi-day process starting from the compounds of the formulae II and III n n R.sup.1 --SH, II n n ##STR2## where the substituents R 1 , R 2 and R 3 have the meanings given.