CAS: 610-93-5; 6-Nitroisobenzofuran-1(3H)-One

上下游产品

4-nitrophthalic anhydride 6-nitrobiphthalide -6-nitro-phthalid3-3,4-Methylendioxy-benzyliden-6-nitro-phthalid H-isobenzofuran-1-one3-benzylidene-6-nitro-3H-isobenzofuran-1-one H-isobenzofuran-1-one3-(4-methoxy-benzylidene)-6-nitro-3H-isobenzofuran-1-one H-isobenzofuran-1-one3-(2-hydroxy-benzylidene)-6-nitro-3H-isobenzofuran-1-one

📜苯酞置于硫酸,Potassium Nitrate体系中,化学反应 2.5H,以87%的收率获得产物6-硝基苯酞
参考文献:作为正电子发射断层扫描和光学成像双峰标签潜在前体的邻碘碘苄醇‒bodipy结构的合成
标题:作为正电子发射断层扫描和光学成像双峰标签潜在前体的邻碘碘苄醇‒bodipy结构的合成
摘要:为了使新型潜在示踪剂从实验台到床头的快速发展,正电子发射断层扫描(pet)和光学成像(oi)的多峰示踪剂已成为一种非常有前途的工具.的确,它们结合了使用光学技术进行体外/体内临床前研究的简便性,以及使用其放射性版本的pet成像所提供的各种临床可能性.在这种情况下,研发了新的标签的制备,该标签可通过荧光成像检测并且潜在地适用于相应的前体的最后一步11 C-标记后的pet成像.通过链接o探索各种设计和综合-碘苄基醇和四甲基-Bodipy部分一起.其中,最有希望的结构是由市售廉价的起始原料通过五个步骤以30%的产率生产的.
DOI:10.1016/j.Tet.2019.130765

专利信息

专利号:US-7329515-B2
优先权日:2003-04-21
标题 :Solid support for the synthesis of 3′-amino oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS
权利人:SIGMA ALDRICH CO
摘要:The present invention discloses novel methods and solid supports for the synthesis of 3′-amino oligonucleotides. The novel supports are based on an unsubstituted or ring-substituted hydroxymethylbenzoyl linker element wherein the hydroxymethyl group is esterified to a solid phase bound carboxylic acid and the carbonyl group is linked to an amino alcohol as an amide. Oligonucleotides are conveniently synthesized on the novel supports with no modifications in the standard phosphoramidite synthesis scheme. The ester function of the support is cleaved under the alkaline deprotection conditions for oligonucleotides to provide a free hydroxymethyl group that aids in the release of the 3′-amino oligonucleotide products with a free amino group through neighbor group participation. The free amino group of the oligonucleotides is available for further conjugation reactions to haptens, reporter groups, surfaces or other small molecules or biomolecules. The methods provided are particularly mild, do not require any modifications in standard protocols for the synthesis and deprotection of oligonucleotides, provide the 3′-amino oligonucleotides free of side products and do not introduce chiral centers to the oligonucleotides.

专利号:US-8362234-B2
优先权日:2006-03-24
标题 :Solid support reagents for synthesis
发明人：HATALA PAUL J; KURZ MARKUS
权利人:ARCHEMIX LLC; HATALA PAUL J; KURZ MARKUS
摘要:The present invention relates to a compound according to the formula: n nwherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , Y, Z, n, s, and t are as defined herein. These compounds are useful for methods of solid phase synthesis.

专利号:US-3651126-A
优先权日:1969-01-16
标 题 :Preparation of o-methylbenzoic acid and derivatives thereof
发明人：JUREWICZ ANTHONY T; FORNEY LE ROY S
权利人:MOBIL OIL CORP
摘要:PHTHALIDE AND SUBSTITUTED (4,5,6,7 POSITIONS) DERIVATIVES ARE CONVERTED TO O-METHYLBENZOIC ACIDS BY HYDROGENOLYSIS IN ALCOHOL, USING A PROTIC ACID CATALYST, OVER PALLADIUM METAL CATALYST, O-METHYLTEREPHTHALIC ACID IS PREPARED IN THIS WAY FROM 5-CARBOXYPHTHALIDE, AND IS USEFUL FOR MAKING NON-CRYSTALLINE POLYESTERS. O-METHYLBENZOIC ACIDS HAVE A VARIETY OF USES, SUCH AS THE PREPARATION OF ALKYL AND POLYESTER RESINS AND IN ORGANIC SYNTHESIS.

专利号:US-2004220397-A1
优先权日:2003-04-21
标题:Solid support for the synthesis of 3'-amino oligonucleotides