CAS: 5632-13-3; Quinolin-4-Ylmethanamine

相似化合物

4363-95-5 1095661-17-8 878778-84-8

上下游产品

CAS号126921-64-0 4-(nitrosomethy... | CAS号1001242-54-1 2-(quinolin-4-y... | CAS号2973-27-5 喹啉-4-甲腈 | CAS号4363-93-3 4-喹啉甲醛 | CAS号3964-04-3 4-溴喹啉 | CAS号7647-01-0 盐酸 | CAS号64-19-7 冰醋酸 | CAS号78811-99-1 [N'-(quinolin-4...

📜喹啉-4-甲腈置于氢气体系中,用 二氯甲烷 作为反应溶剂,35.0 °C,103.42 Kpa 条件下,反应 0.75H,以94%的收率获得产物4-氨基甲基喹啉盐酸盐
参考文献:富含喹啉生物碱的quisqualis印度花提取物可增强生物活性
标题:富含喹啉生物碱的quisqualis印度花提取物可增强生物活性
摘要:摘要 从印度qui藜花提取物中分离出挥发性生物碱喹啉-4-腈(qcn).主要化合物为反式-芳樟醇氧化物(1.0,4.5%),苯甲酸甲酯(1.0,4.0%),2,2,6-三甲基-6-乙烯基-四氢吡喃-3-酮(7.4,17.8%),2,2,6-三甲基-6-乙烯基四氢吡喃-3-醇(1.0,1.2%),(e,E活花和采摘花中的)-α-法呢烯(29.1,16.1%),Qcn(5.7,1.3%).由于采摘时酶促反应的变化,花的组成发生了变化.加氢蒸馏过程中发生了一些氧化萜烯重排反应,从而获得了香精油.通过绿色反应过程制备了qcn及其由qcn衍生的选择性还原产物的化学合成方法.qcn的催化改性产生了喹啉-4-甲胺.后来的化合物显示出增强的生物活性.qcn和花卉提取物(绝对)已显示出潜在的抗炎和抗氧化活性.此外,由于改善了qcn(19.
DOI:10.1080/14786419.2019.1634709

专利信息

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:RU-2114829-C1
优先权日:1991-08-12
标题:1,2,4-substituted piperidines and a method of their synthesis, intermedium compounds of piperidone and a method of their synthesis, pharmaceutical composition based on new compounds