CAS: 56-73-5; D-Glucose 6-Phosphate

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54010-71-8 17187-72-3 6665-00-5

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Sorbitol 6-phosphate D-glucose D-Fructose 5,6-anhydro-1,2-O-isopropylidene-α-D-glucofuranoseSorbitol 6-phosphate 6-phosphoglucono-δ-lactone D-erythrose 4-phosphateD-erythrose 4-phosphate 6-phosphogluconic acid

📜对氟苯甲醇置于recombinant Giardia Lamblia Phosphoglucomutase 1,烟酰胺腺嘌呤双核苷酸磷酸盐,Magnesium Chloride体系中,化学反应生成 α-D-吡喃葡萄糖6-磷酸
参考文献:A Deeply Divergent Phosphoglucomutase (Pgm) Of Giardia Lamblia Has Both Pgm And Phosphomannomutase Activities
标题:A Deeply Divergent Phosphoglucomutase (Pgm) Of Giardia Lamblia Has Both Pgm And Phosphomannomutase Activities
摘要:贾第虫(giardia Lamblia)是引起腹泻的重要寄生虫,其利用葡萄糖的活化形式合成糖原,以及利用甘露糖的活化形式合成甘油磷酸肌醇锚.葡萄糖活化的一个必要步骤是通过磷酸葡萄糖变位酶(pgm)将葡萄糖-6-磷酸异构化为葡萄糖-1-磷酸.同样,磷酸甘露糖变位酶(pmm)则将甘露糖-6-磷酸转化为甘露糖-1-磷酸.虽然贾第虫的全基因组序列预测出了两个pgm候选基因,但并没有发现pmm候选基因.本研究测试的假设是,这两个贾第虫pgm候选基因中至少有一个同时具有pgm和pmm活性,正如细菌pgm同源物所描述的那样.非变性凝胶显示贾第虫有两种具有pgm活性的蛋白,其中一种也具有pmm活性.系统发育分析表明,这两种贾第虫pgm候选基因中的一种(gl-Pgm1)与其他真核生物的pgm共享近期共同祖先,而另一种贾第虫pgm候选基因(gl-Pgm2)则与之有很大差异.gl-Pgm1和gl-Pgm2均能拯救酿酒酵母(saccharomyces Cerevisiae)中的pgm1δ/pgm2δ双缺失株,而只有gl-Pgm2能拯救酿酒酵母的温敏pmm突变株(sec53-Ts).重组gl-Pgm1仅具有pgm活性,而gl-Pgm2则同时具有pgm和pmm活性.我们得出结论,Gl-Pgm1表现为一种传统的真核生物pgm,而gl-Pgm2是一种具有pmm活性的新的真核生物pgm.
DOI:10.1093/glycob/cwq081

专利信息

专利号:US-7041479-B2
优先权日:2000-09-06
标题 :Enhanced in vitro synthesis of active proteins containing disulfide bonds
发明人：SWARTZ JAMES ROBERT; KIM DONG-MYUNG
权利人:TRUSTESS OF THE LELAND STANFOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.

专利号:US-5824472-A
优先权日:1986-03-24
标 题 :Process for the synthesis of sugar nucleotides using recombinant-DNA methods
发明人：BETLACH MICHAEL R; DOHERTY DANIEL H; VANDERSLICE REBECCA W
权利人:MONSANTO CO
摘要:A recombinant-DNA mediated method for the synthesis of sugar nucleotides is disclosed. This method utilizes portable DNA sequences capable of directing the microbial synthesis of various enzymes that catalyze the synthesis of sugar nucleotides, including UDP-glucose, UDP-glucuronic acid and GDP-mannose. The sugar moieties of these sugar nucleotides may subsequently be incorporated into industrially-useful polysaccharides such as xanthan gum. It has been found that vectors containing the portable DNA sequences described herein are capable both of causing sugar nucleotide production in microorganisms previously incapable of such synthesis and of causing increased sugar nucleotide production in organisms capable of synthesizing small quantities of these compounds. In particular, plasmids pAS7, pAS9 and pTS13 are disclosed. These plasmids are capable of directing sugar nucleotide synthesis in various hosts, including Xanthomonas sp. such as X. campestris and other organisms such as E. coli and various Pseudomonas sp.

专利号:US-2012190064-A1
优先权日:2004-10-01
标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
发明人：KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

专利号:EP-1641812-B1
优先权日:2003-06-30
标题 :PURE d-(17alpha)-13-ETHYL-17-HYDROXY-18,19-DINORPREGN-4-ENE-20-YNE-3-ONE-3E- AND -3Z-OXIME ISOMERS, AS WELL AS PROCESS FOR THE SYNTHESIS OF THE MIXTURE OF ISOMERS AND THE PURE ISOMERS
发明人：TUBA ZOLTAN; MAHO SANDOR; KESERU GYOERGY; KOZMA JOZSEF; HORVATH JANOS; BALOGH GABOR
权利人:RICHTER GEDEON NYRT
摘要:The invention relates to the pure d-(17alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-­20-yne-3-one-3E-oxime isomer of formula (IA), the pure d-(17alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yne-3-one-3Z-oxime isomer of formula (IB), which are of gestagen activity, as well as the process for the synthesis of the mixture of the above isomers and the pure isomers. The invention also relates to the pharmaceutical compositions - and the process for their synthesis - which contain either the pure isomer of formula (IA) or the pure isomer of formula (IB) as active ingredient as such or in combination with other active ingredients (for example an oestrogen agent) together with pharmaceutical auxiliary materials commonly used in practice.

专利号:US-9643915-B2
优先权日:2013-03-15
标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-9708354-B2
优先权日:2013-03-15
标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.