CAS: 5424-47-5; 2-[3-(Dimethylamino)Propionyl]Thiophene Hydrochloride

2-乙酰基噻吩 以73的收率获得产物3-二甲基氨基-1-(噻吩基)-1-丙酮盐酸盐
参考文献:Process For Making Duloxetine And Related Compounds
标题:Process For Making Duloxetine And Related Compounds
摘要:化合物10的公式在制备度洛西汀中是有用的.

专利信息

专利号:US-5491243-A
优先权日:1993-10-12
标题 :Intermediate useful for the asymmetric synthesis of duloxetine
发明人：BERGLUND RICHARD A
权利人:LILLY CO ELI
摘要:This invention provides a stereospecific process for the synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a key intermediate in the synthesis of duloxetine.

专利号:EP-1857451-B1
优先权日:2006-05-05
标 题:A process for the preparation of an intermediate useful for the asymmetric synthesis of (+)duloxetine
发明人：POGGIALI ANDREA; PIZZOCARO FRANCESCO; TUBERTINI PAOLO
权利人:FIDIA FARMACEUTICI
摘要:A process for the preparation of (+)duloxetine, or an acid addition salt thereof, comprising: n(i) Resolving racemic (±)N-methyl duloxetine with a less than stoichiometric amount of a chiral acid in combination with suitable amounts of a hydrohalogen acid to give a salt of the chiral acid and (+)N-methyl duloxetine, substantially free from (-)N-methyl duloxetine; n(ii) Demethylating the (+)N-methyl duloxetine prepared in step (i) to give (+)duloxetine or another acid addition salt in enantiomerically pure form.

专利号:EP-1857451-A1
优先权日:2006-05-05
标题 :A process for the preparation of an intermediate useful for the asymmetric synthesis of (+)duloxetine

专利号:CN-105274069-B
优先权日:2014-07-07
标题:A kind of alcohol dehydrogenase and its application in the synthesis of duloxetine intermediate

专利号:US-12398126-B2
优先权日:2019-06-06
标 题:Process to synthesize 5-(3pyridyl)-2,2′-bithiophene(sensitizer)
发明人：DATLA ANUPAMA; NAGRE PRASHANT; TAMORE JAGDISH; TRIVIKRAM SREENATH; DEGAONKAR GAJANAN
权利人:FERMENTA BIOTECH LTD
摘要:The present invention discloses an improved catalytic process for the synthesis of 5-(3-pyridyl)-2,2′-bithiophene in high yield and purity.

专利号:EP-0650965-B1
优先权日:1993-10-12
标题:Asymmetric synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine an intermediate in the preparation of duloxetine