CAS: 5402-55-1; 2-Thiopheneethanol

上下游产品

CAS号1918-77-0 2-噻吩乙酸 | CAS号57382-97-5 2-噻吩乙酸乙酯 | CAS号75-21-8 环氧乙烷 | CAS号188290-36-0 Thiophene(SIV) | CAS号19432-68-9 2-噻吩乙酸甲酯 | CAS号1072-53-3 1,3,2-二噁唑噻吩-2,2-二氧化物 | CAS号89180-57-4 2-thiophenemagn... | CAS号96-43-5 2-氯噻吩 | CAS号5713-61-1 2-噻吩基溴化镁 | CAS号63762-35-6 2,5-dilithiothi... | CAS号40412-06-4 2-(噻吩-2-基)乙基 4-... | CAS号99755-59-6 罗替高汀 | CAS号1918-82-7 2-乙烯基噻吩 | CAS号57153-43-2 (4-甲基-6,7-二氢-4H... | CAS号554-14-3 2-甲基噻吩 | CAS号131202-63-6 5-(2-hydroxyeth... | CAS号132465-10-2 (E)-2-(噻吩-2-基)乙... | CAS号160744-11-6 2-[2-(叔丁基二甲基甲硅烷... | CAS号160744-13-8 5-(2-羟乙基)-2-噻吩羧酸甲酯 | CAS号106891-32-1 甲基-(2-噻吩-2-基-乙基)胺

2,2,2-三氯-1-(噻吩-2-基)-乙醇置于锂硼氢,Sodium Hydroxide体系中,用 异丙醇 作为反应溶剂,以89%的收率获得产物2-噻吩乙醇
参考文献:伯醇的单碳认证和涉及 Jocic 型反应的醛的还原认证
标题:伯醇的单碳认证和涉及 Jocic 型反应的醛的还原认证
摘要:(三氯甲基)甲醇在一次操作中由醇或醛形成,可在涉及 Libh4 的 Jocic 型反应中转化为伯醇.最终结果是方便的两步,伯醇的单碳同源或醛的还原性单碳同源,具有广泛的底物范围.该方法是步骤经济的,它很好地补充了已建立的单碳同源策略.
DOI:10.1002/ejoc.201501089

专利信息

专利号:EP-0439404-B1
优先权日:1990-01-25
标题 :Preparation of 2-(2'-thienyl) alkylamines and derivatives thereof and synthesis of 4,5,6,7- thieno [3,2-c] pyridine derivatives therefrom
发明人：KHATRI HIRALAL N; DEHOFF BRADLEY S
权利人:SANOFI SA
摘要:An improved process for the synthesis of 2-(2 min -thienyl)ethylamine from suitably functionalized derivatives of 2-(2 min -thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2 min -thienyl)ethylamine produced by this process is advantageously converted to the carbamic acid salt, which is suitably reconverted to 2-(2 min -thienyl)ethylamine, a useful intermediate in the synthesis of ticlopidine.

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:US-5068360-A
优先权日:1990-01-25
标题 :Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno(3,2-C)pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-5191090-A
优先权日:1990-01-25
标题:Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno[3,2-c]pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-7342003-B2
优先权日:2001-10-25
标 题 :Synthesis of 2-aralkyloxyadenosines, 2-alkoxyadenosines, and their analogs
发明人：MOORMAN ALLAN R; SCANNELL MICHAEL; BALASUBRAMANIAN THIAGARAJAN; OUTCALT RUSSELL; LEUNG EDWARD
权利人:KING PHARMACEUTICALS RES & DEV
摘要:Provided is a method for the synthesis of an aralkyloxyadenosine or an alkoxyadenosine. The method includes protecting the hydroxyl sugar groups with a protecting group to produce a protected halogenated adenosine. The protected halogenated adenosine is alkoxylated, and the hydroxyl sugar groups of the protected halogenated adenosine are deprotected to provide the aralkyloxyadenosine or alkoxyadenosine.

专利号:US-9765027-B2
优先权日:2014-08-22
标题 :Substituted 1-arylethyl-4-acylaminopiperidine derivatives as opioid/alpha-adrenoreceptor modulators and method of their preparation
发明人：VARDANYAN RUBEN S; HRUBY VICTOR J
权利人:THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZAONA; UNIV ARIZONA
摘要:The invention provides compounds that bind with high affinities to the μ-, δ- and κ-opioid receptors and α 2 -adrenoreceptor. In addition to providing these compounds with novel pharmacological binding properties, the invention also describes detailed novel methods for the preparation of representative compounds and a scheme for the synthesis of related compounds that bind to the opioid receptors and/or α 2 -adrenoreceptor.