📜草酸二丁酯,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于sodium Butanolate体系中,化学反应生成 避虫酮 参考文献:Butyl Esters Of Alpha,Alpha-Dimethyl-Alpha-Carboxydihydro-Gammapyrone And To Process For Making The Same 标题:Butyl Esters Of Alpha,Alpha-Dimethyl-Alpha-Carboxydihydro-Gammapyrone And To Process For Making The Same
专利号:WO-2017077549-A1 优先权日:2015-11-02 标题 :Analogues of angiopterlactone b and a process for the synthesis thereof 发明人:BHATTACHARYA ASISH KUMAR; KOTAMMAGARI THARUN KUMAR 权利人:COUNCIL SCIENT IND RES 摘要:The invention discloses a novel analogues of Angiopterlactone B of formula (I) and process for the synthesis thereof. Further the present invention discloses a total synthetic one pot process for the synthesis of Angiopterlactone B and its analogues comprises the reaction of the dihydro pyronones with Tetra-n-butylammonium fluoride (TBAF) in dry solvent for the time period ranging from 1-2 hours at the temperature ranging from 20-30°C, working up and subjecting the residue to column chromatography to obtain the product.
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:WO-9848791-A1 优先权日:1997-04-30 标 题:Synthesis of discodermolide and analogs 发明人:MYLES DAVID C; HARRIED SCOTT S; YANG GE 权利人:UNIV CALIFORNIA; MYLES DAVID C; HARRIED SCOTT S; YANG GE 摘要:A method for making discodermolide and analogs thereof. The method utilizes three precursors which correspond to three subparts of discodermolide which are formed by disconnecting the discodermolide carbon backbone at positions C-7 to C-8 and C-15 to C-16. Coupling of the precursors is accomplished using chelation-controlled alkylation.
专利号:US-2005043376-A1 优先权日:1996-12-03 标题:Synthesis of epothilones, intermediates thereto, analogues and uses thereof 发明人:DANISHEFSKY SAMUEL J; BERTINATO PETER; SU DAI-SHI; MENG DONGFANG; CHOU TING-CHAO; KAMENECKA TED; SORENSEN ERIK J; BALOG AARON; SAVIN KENNETH A 摘要:The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
专利号:US-RE41990-E 优先权日:1996-12-03 标 题 :Synthesis of epothilones, intermediates thereto, analogues and uses thereof 发明人:DANISHEFSKY SAMUEL J; BERTINATO PETER; SU DAI-SHI; MENG DONGFANG; CHOU TING-CHAO; KAMENECKA TED; SORENSEN ERIK J; BALOG AARON; SAVIN KENNETH A 权利人:SLOAN KETTERING INST CANCER 摘要:The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
专利号:EP-1058679-B1 优先权日:1998-02-25 标 题 :Synthesis of epothilones, intermediates thereto and analogues therof 发明人:DANISHEFSKY SAMUEL J; BALOG AARON; BERTINATO PETER; SU DAI-SHI; CHOU TING-CHAU; MENG DONGFANG; KAMENECKA TED; SORENSEN ERIK J; KUDUK SCOTT; HARRIS CHRISTINA; ZHANG XIU-GUO; BERTINO JOSEPH R 权利人:SLOAN KETTERING INST CANCER 摘要:The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.
摘要:Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 586 摘要:Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-345 摘要:Franke C et al; Chemosphere 29: 1501-14 (1994) 摘要:Worthing, C. R. (ed.). Pesticide Manual. 6th ed. Worcestershire, England: British Crop Protection Council, l979., p. 66 摘要:Mill T et al; Environmental Fate and Exposure Studies Development of a PC-SAR for Hydrolysis: Esters, Alkyl Halides and Epoxides. EPA Contract No. 68-02-4254. Menlo Park, CA: SRI International (1987)