CAS: 4152-09-4; N1-Benzylethane-1,2-Diamine

上下游产品

ethyleneimine benzylamine formic acid N,N'-bis(benzyliden)ethylendiamineN-Benzyl-N,N'-dibenzoylethylenediamine N-benzyl-N',N'''-diphenyl-N,N''-ethanediyl-bis-thioureaN-benzyl-N',N'''-diphenyl-N,N''-ethanediyl-bis-thiourea 1-benzyl-2-methyl-4,5-dihydro-1H-imidazole (3-benzyl-2-diethylamino-[1,3,2]diazaphospholidin-1-yl)-phosphonous acid bis-diethylamide

溴甲苯置于potassium Carbonate,三氟乙酸体系中,用 二氯甲烷,乙腈 作为反应溶剂,化学反应 3.0H,反应生成 N-苄基乙二胺
参考文献:新型咪唑并[1,2-A]吡啶-3-羧酰胺衍生物的设计,合成及抗分枝杆菌活性
标题:新型咪唑并[1,2-A]吡啶-3-羧酰胺衍生物的设计,合成及抗分枝杆菌活性
摘要:我们在此报告基于我们实验室中发现的imb-1402的结构和合成的"新型咪唑并[1,2-A]吡啶-3-甲酰胺(ipa)"的设计和合成.结果表明,在苯环上具有给电子基团的2,6-二甲基-N-[2-(苯基氨基)乙基] Ipas作为有效的支架.化合物26G和26H对药物敏感/耐药的mtb菌株具有相当大的活性(mic:0.041-2.64μm),并且它们对mtb H37Rv的安全性指标可接受,Si值分别为4395和1405.此外,N-[2-(哌嗪-1-基)乙基]部分也被鉴定为潜在的替代接头(化合物31),为进一步的sar研究开辟了新的方向.
DOI:10.1016/j.Ejmech.2017.05.044

专利信息

专利号:WO-0058264-A1
优先权日:1999-03-26
标 题:Method for the synthesis of non-symmetrical dtpa compounds
发明人：ACHILEFU SAMUEL I; SRINIVASAN ANANTHACHARI
权利人:MALLINCKRODT INC; ACHILEFU SAMUEL I; SRINIVASAN ANANTHACHARI
摘要:The synthesis of compounds of formula (XIV) wherein each R4 is an alkyl group having 1 to 15 carbon atoms, and R6 is a linking moiety having 1 to 10 carbon atoms, is disclosed. These compounds are useful intermediates in the synthesis of compounds of formula (X). These compounds are useful in the preparation of nuclear pharmaceuticals such as those used for tumor imaging or tumor therapy.

专利号:WO-0058266-A1
优先权日:1999-03-26
标题:Divergent method for the synthesis of diethylene triaminepenta aceticacid esters
发明人：ACHILEFU SAMUEL I; SRINIVASAN ANANTHACHARI
权利人:MALLINCKRODT INC; ACHILEFU SAMUEL I; SRINIVASAN ANANTHACHARI
摘要:The synthesis of compounds of formula (X) is disclosed. These compounds are useful in the preparation of nuclear pharmaceuticals such as those used for tumor imaging or tumor therapy.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-2016168138-A1
优先权日:2013-07-15
标题:Process for the preparation of suvorexant and intermediates useful in the synthesis of suvorexant
发明人：IQBAL JAVED; DAHANUKAR VILAS HARESHWAR; ORUGANTI SRINIVAS; KANDAGATLA BHASKAR
权利人:REDDY S LAB LIMTED DR
摘要:A novel processes for the preparation of suvorexant (formula I), its related compounds and its intermediates that are simple, economical and commercially viable. (I)

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-2013102730-A1
优先权日:2010-04-02
标 题:Polyamine-containing polymers and methods of synthesis and use
发明人：JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN
权利人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN; ALBERTA INNOVATES TECHNOLOGY FUTURES
摘要:The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).