CAS: 2601-89-0; 2,3-Dichloropropanenitrile

相似化合物

1617-17-0 565-64-0 19433-84-2

上下游产品

CAS号107-13-1 丙烯腈 | CAS号813-74-1 2,2,3-三氯丙腈 | CAS号598-79-8 2-氯丙烯酸 | CAS号920-37-6 2-氯丙烯腈 | CAS号19433-84-2 2,3-二氯丙酰胺 | CAS号1128-56-9 1-苯基-3-氨基吡唑

丙烯腈置于吡啶体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 5.0H,反应生成2,3-二氯丙腈
参考文献:一种3-氨基异噁唑的制备方法
标题:一种3-氨基异噁唑的制备方法
摘要:本发明属于医药技术领域,具体涉及一种3‑氨基异噁唑的制备方法:(1)2,3‑二氯丙腈的制备:反应容器中投入丙烯腈,N,N‑二甲基甲酰胺,吡啶,降温至5~15°C,反应容器中通入氯气,保持反应温度10‑20oc;通入氯气结束后控温15~25oc搅拌5小时;鼓吹出多余氯气,至反应液为微黄色或者无色透明,得到2,3‑二氯丙腈;(2)3‑氨基异噁唑的制备:在碱性条件下,以羟基脲和2,3‑二氯丙腈为原料,N,N‑二甲基甲酰胺为催化剂,合成得到3‑氨基异噁唑.本发明用以解决现有3‑氨基异噁唑制备采用2,3‑二溴丙腈中间体导致极易冲料,工艺危险性大的技术问题.

专利信息

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:DE-69604247-T2
优先权日:1995-07-19
标 题:2-cyanopiperazine and its use for the synthesis of biologically active substances

专利号:EP-0754686-B1
优先权日:1995-07-19
标 题 :2-cyanopiperazine and use thereof for the synthesis of biologically active substances

专利号:EP-0040896-B1
优先权日:1978-08-22
标题:Synthesis of amides

专利号:EP-0754686-A1
优先权日:1995-07-19
标题 :2-cyanopiperazine and use thereof for the synthesis of biologically active substances

专利号:CN-113754561-B
优先权日:2021-08-20
标 题:A method for producing 2-chloroacrylonitrile and its application in the synthesis of chlorfenapyr