专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:US-4049710-A 优先权日:1976-02-24 标题:Novel carbamimidoyl chlorides and their use in the synthesis of herbicidal triazinediones 发明人:TOCKER STANLEY 权利人:DU PONT 摘要:Carbamimidoyl chlorides of the formula: WHERE R2 is alkyl of 1-4 carbon atoms are useful as intermediates in the synthesis of herbicidal triazinediones of the formula: where R1 is certain organic radicals.
专利号:US-6610844-B2 优先权日:1996-12-11 标题:Processes for preparation of 9,11-epoxy steroids and intermediates useful therein 发明人:NG JOHN S; LIU CHIN; ANDERSON DENNIS K; LAWSON JON P; WIECZOREK JOSEPH; KUNDA SASTRY A; LETENDRE LEO J; POZZO MARK J; SING YUEN-LUNG L; WANG PING T; YONAN EDWARD E; WEIER RICHARD M; KOWAR THOMAS R; BAEZ JULIO A; ERB BERNHARD 权利人:SEARLE & CO 摘要:Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula Iwherein-A-A- represents the group -CHR4-CHR5- or -CR4=CR5-;R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano and aryloxy;R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical;-B-B- represents the group -CHR6-CHR7- or an alpha- or beta-oriented group:where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy; andR8 and R9 are independently selected from the group consisting of hydrogen, hydroxy, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonylalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R6 or comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.
专利号:WO-2013067646-A1 优先权日:2011-11-12 标题:Process for the synthesis of beta-aminocarbonyls 发明人:BEAUCHEMIN ANDRE MARTIN; CLAVETTE CHRISTIAN; GAN WEI; MARKIEWICZ THOMAS; TODERIAN AMY BEVERLY 权利人:UNIV OTTAWA 摘要:The present application provides processes and intermediates useful in the production of β- aminocarbonyl- or β-aminothiocarbonyl-containing compounds. Provided herein is a process for synthesizing β-aminocarbonyl- or β-aminothiocarbonyl-containing compounds from an alkene and a hydrazone. Also provided herein is a process for synthesizing β-aminocarbonyl- or β-aminothiocarbonyl-containing compounds from an alkene and a hydrazine. The present application further provides intermediate aminoisocyanate and iminoisocyanate compounds, and methods for synthesizing the starting hydrazone and hydrazine compounds.
专利号:US-6472539-B1 优先权日:2000-01-07 标题 :Production process of diphosphine oxide and diphosphonate 发明人:YOKOZAWA TOHRU; SAITO TAKAO; SAYO NOBORU; ISHIZAKI TAKERO 权利人:TAKASAGO PERFUMERY CO LTD 摘要:A process for producing a diphosphine oxide or diphosphonate represented by formula (1) as defined, which comprises treating, with a base, a phosphine compound represented by formula (2) as defined and adding the thus-treated phosphine compound to a nonpolar solvent having an oxidative metal compound suspended therein so as to effect dimerization. The present invention makes it possible to produce, conveniently, in a high yield and safely, a diphosphine oxide or diphosphonate which is an intermediate for producing a diphosphine compound useful as a ligand of a metal complex serving as a catalyst for asymmetric synthesis reaction.
专利号:WO-2023002323-A1 优先权日:2021-07-19 标 题 :Synthesis of substituted tricyclic amides and analogues thereof
参考文献:10.1055/s-2006-958930 摘要:Lesiv A, Ioffe S, Sukhorukov A, Klenov M, Ivashkin P, Khomutova Y. A Convenient Procedure for the Synthesis of 3-Substituted 5,6-Dihydro-4H-1,2-oxazines from Nitroethane. Synthesis. 2007 Jan;2007(1):97–107. doi: 10.1055/s-2006-958930. 参考文献:10.1007/978-94-017-6790-3_7 摘要:Broersma S. Calculation of and Errors in the Susceptibility. 1947. In: Magnetic Measurements on Organic Compounds. 参考文献:10.1055/s-2006-949616 摘要:Eliseev O, Ioffe S, Ivashkin P, Ostapenko A, Lesiv A, Khomutova Y, Lapidus A. Catalytic Carbonylation of 3-Bromomethyl-5,6-dihydro-4H-1,2-oxazines: General Approach to the Synthesis of 3-Methoxycarbonylmethyl-5,6-dihydro-4H-1,2-oxazines from Available Precursors. Synlett. 2006 Sep;2006(14):2239–40. doi: 10.1055/s-2006-949616. 参考文献:10.1007/978-3-031-36068-8_8 摘要:Ahluwalia VK, Aggarwal R. Conformations of Cycloalkanes. 2023. In: Alicyclic Chemistry.