CAS: 133052-90-1; 3-(1-(3-(Dimethylamino)Propyl)-1H-Indol-3-yl)-4-(1H-Indol-3-yl)-1H-Pyrrole-2,5-Dione

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CAS号124-40-3 二甲胺 | CAS号18372-22-0 吲哚-3-乙醛酸甲酯 | CAS号170364-27-9 3-[1-(3-hydroxy... | CAS号120-72-9 吲哚 | CAS号1477-49-2 3-吲哚乙醛酸 | CAS号22980-09-2 吲哚-3-乙醛酰氯 | CAS号91026-01-6 2,3-双(1H-吲哚-3-基...

📜吲哚-3-乙醛酰氯置于吡啶,Potassium Tert-Butylate体系中,用 四氢呋喃,甲醇,乙醚,二氯甲烷,水 用作溶剂,化学反应 21.5H,反应生成3-[1-[3-(二甲氨基)丙基]1H-吲哚-3-基]-4-(吲哚-3-基)1H-吡咯-2,5二酮
参考文献:A New,Efficient Method For The Synthesis Of Bisindolylmaleimides
标题:A New,Efficient Method For The Synthesis Of Bisindolylmaleimides
摘要:
Doi:10.1021/jo980513C

专利信息

专利号:US-5665877-A
优先权日:1993-12-07
标题:Synthesis of bisindolylmaleimides
发明人：FAUL MARGARET M; JIROUSEK MICHAEL R; WINNEROSKI II LEONARD L
权利人:LILLY CO ELI
摘要:The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.

专利号:US-5541347-A
优先权日:1993-12-07
标 题 :Synthesis of bisindolylmaleimides
发明人：FAUL MARGARET M; JIROUSEK MICHAEL R; WINNEROSKI II LEONARD L
权利人:LILLY CO ELI
摘要:The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.

专利号:US-7232842-B2
优先权日:2003-01-10
标题:Kinase inhibitors and associated pharmaceutical compositions and methods of use
发明人：WENDER PAUL A; SCANIO MARC J
权利人:UNIV LELAND STANFORD JUNIOR
摘要:The invention provides novel compounds useful as kinase inhibitors or as starting materials And/or intermediates in the synthesis of compounds useful as kinase inhibitors. The compounds have The general structure of formula (I) n nwherein A is a 3- to 8-membered ring, optionally substituted and/or heteroatom-containing, and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X, Y, Z, p, and q are as defined herein. The compounds may also be in the form of a salt, ester, amide, or other analog. In preferred compounds, A is a 5- to 8-membered ring, R 1 is hydrogen, q is a bond, X is N, Y is Câ•?O, Z is N, R 2 contains a terminal amino moiety, p is 1, and R 3 and R 4 are linked to form a pyrrole ring fused to a second cyclic group. Pharmaceutical compositions and methods for using the compounds are also provided.

专利号:US-6133452-A
优先权日:1997-08-22
标题 :Synthesis of bisindolylmalimides
发明人：FAUL MARGARET MARY; WINNEROSKI JR LEONARD LARRY
权利人:LILLY CO ELI
摘要:The present invention provides for the reaction of optionally substituted indole-3-acetamides with optionally substituted methyl indole-3-glyoxyl reagent to prepare potent PKC inhibitors. The reaction is very efficient and robust macrocyclization methodology.

专利号:US-6229055-B1
优先权日:1996-04-12
标题 :Synthesis of fluorinated xanthene derivatives
发明人：KLAUBERT DIETER H; GEE KYLE R
权利人:MOLECULAR PROBES INC
摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.

专利号:US-6037475-A
优先权日:1996-03-20
标题:Synthesis of indolymaleimides
发明人：FAUL MARGARET M; JIROUSEK MICHAEL R; MCDONALD III JOHN H; NEEL DAVID ANDREW
权利人:LILLY CO ELI
摘要:The present invention provides a method for synthesizing indolylmaleimides by reacting an activated maleimide preferably with an optionally substituted organometalic-3-indole in the presence of a transition metal catalyst.