CAS: 1257529-92-2; (3S,5S)-5-((1S,3S)-1-Azido-3-(Hydroxy(4-Methoxy-3-(3-Methoxypropoxy)Phenyl)Methyl)-4-Methylpentyl)-3-Isopropyldihydrofuran-2(3H)-One

英文名称(3S,5S)-5-((1S,3S)-1-Azido-3-(Hydroxy(4-Methoxy-3-(3-Methoxypropoxy)Phenyl)Methyl)-4-Methylpentyl)-3-Isopropyldihydrofuran-2(3H)-One
中文名称(3S,5S)-5-[(1S,3S)-1-叠氮基-3-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]羟甲基]-4-苄基]二氢-3-异丙基-2(3H)-呋喃酮
IUPAC名称(3S,5S)-5-((1S,3S)-1-azido-3-(hydroxy(4-methoxy-3-(3-methoxypropoxy)phenyl)methyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one
其它别名2(3H)-Furanone, 5-[(1S,3S)-1-Azido-3-[hydroxyl[4-Methoxy-3-(3-Methoxypropoxy)Phenyl]Methyl]-4-Methylpentyl]Dihydro-3-(1-Methylethyl)-, (3S,5S)-; 5-[(1S,3S)-1-Azido-3-[hydroxyl[4-Methoxy-3-(3-Methoxypropoxy)Phenyl]Methyl]-4-Methylpentyl]Dihydro-3-(1-Methylethyl)-, (3S,5S)-2(3H)-Furanone; (3S,5S)-5-((1S,3S)-1-Azido-3-(Hydroxy(4-Methoxy-3-(3-Methoxypropoxy)Phenyl)Methyl)-4-Methylpentyl)-3-Isopropyldihydrofuran-2(3H)-One; 2(3H)-Furanone, 5-[(1S,3S)-1-Azido-3-[hydroxyl[4-Methoxy-3-(3-Methoxypropoxy)Phenyl]Methyl]-4-Methylpentyl]Dihydro-3-(1-
CAS编号1257529-92-2
分子式:C25H39N3O6分子量:477.6
产品CID: 385518
产品分类化学试剂 → 有机试剂 → 叠氮

相似结构搜索
InChIKey: DWQWDPBEIBVJGE-AVDDXLGQSA-N
InChI=1S/C25H39N3O6/c1-15(2)18(13-20(27-28-26)22-14-19(16(3)4)25(30)34-22)24(29)17-8-9-21(32-6)23(12-17)33-11-7-10-31-5/h8-9,12,15-16,18-20,22,24,29H,7,10-11,13-14H2,1-6H
计算化学: 氢键受体数8.0氢键供体数1.0可旋转键数14.0

MSDS等安全信息

上下游产品

(2S,4S)-4-azido-2-isopropyl-4-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]butanal 4-bromo-1-methoxy-2-(3-methoxypropoxy)benzene 4-iodo-1-methoxy-2-(3-methoxypropoxy)benzene (2S,2'S,2S,4S)-2-[2-azido-2'-(4-isopropyl-5-oxo-tetrahydrofuran-2-yl)-ethyl]-3-methylbutyric acid (2S,4S)-4-azido-2-isopropyl-4-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-1-(4-methoxy-3-(3-methoxypropoxy)phenyl)butyl isobutyrate (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide aliskiren isobutyric acid salt (2S,4S,5S,7S)-4-amino-7-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-5-hydroxy-2-isopropyl-1-(4-methoxy-3-(3-methoxypropoxy)phenyl)-8-methylnonyl isobutyrate

合成工艺路线路线简述

📜2S-[2[1(R*),2R*,4R*],4]]-3-[4-叠氮-2-异丙基-1-氧代-4-[四氢-4-异丙基-5-氧代-2-呋喃基]丁基]-4-苄基-2-噁唑烷酮置于sodium Hypochlorite,Secbu2Mg Licl,2,2,6,6-四甲基哌啶氧化物,Lithium Hydroxide Monohydrate,Dimethyl Sulfide Borane,双氧水,碳酸氢钠,Potassium Bromide体系中,用四氢呋喃,二氯甲烷,水用作溶剂,化学反应 90.0H,反应生成(3S,5S)-5-[(1S,3S)-1-叠氮基-3-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]羟甲基]-4-苄基]二氢-3-异丙基-2(3H)-呋喃酮
参考文献:通往aliskiren中间体的新合成路线
标题:通往aliskiren中间体的新合成路线
摘要:摘要通过使用有机金属试剂将3,4-二烷氧基苯基单元连接至前体c-8内酯-羧酸衍生物,可以完成aliskiren中间体的合成.观测到内酯-羧酸氯化物底物对有机镁和有机硼试剂的完全不同的反应性. 通过使用有机金属试剂将3,4-二烷氧基苯基单元连接至前体c-8内酯-羧酸衍生物,可以完成aliskiren中间体的合成.观测到内酯-羧酸氯化物底物对有机镁和有机硼试剂的完全不同的反应性.
Doi:10.1055/s-0034-1378616