专利号:US-11858901-B2 优先权日:2019-10-30 标 题:3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6 trifluoromethyl benzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, process for its preparation, and its use in the synthesis of elagolix 发明人:BALLETTE ROBERTO; JIMÉNEZ ALONSO OSCAR; GARCÃ?A GARCÃ?A ELENA; DOBARRO RODRÃ?GUEZ ALICIA 权利人:MOEHS IBERICA SL 摘要:A new intermediate is useful in the synthesis of elagolix. A process for obtaining the intermediate includes reacting a precursor with iodine monochloride in the presence of an organic solvent. A process for preparing elagolix makes use of the intermediate. The intermediate can be 3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethylbenzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, such as a hydrochloride.
专利号:US-11718584-B2 优先权日:2019-02-22 标题 :Process for the synthesis anthranilic diamide compounds and intermediates thereof 发明人:KARRI PHANEENDRASAI; PABBA JAGADISH; SHINDE BHARAT UTTAMRAO; KALWAGHE AMOL DNYANESHWAR; MADHAVRAO KAMBLE MARUTI; KLAUSENER ALEXANDER G M; PANMAND DEEPAK SHANKAR 权利人:PI INDUSTRIES LTD 摘要:The present invention disclosed a process for the synthesis of anthranilic diamide compound of formula (I), n n n n n n n n n n wherein, R 1 , R 2 , R 3a , R 3b , R 3c , R 4 , R 5 , R 6 and Z are as defined in the detailed description. The process comprising the step of obtaining a mono- or dicyano substituted aniline compound of formula (IV) which is then converted to an anthranilic acid compound of formula (V) or an anthranilic amide compound of formula (Va). Further, the compound of formula (VI) can be optionally synthesized from compound of formula (IV or V or Va)
专利号:US-2022411382-A1 优先权日:2019-10-30 标 题 :3-((r)-2-(amino-2-phenylethyl)-1-(2-fluoro-6 trifluoromethyl benzyl)-5-iodo-6-methyl-1h-pyrimidine-2,4-dione or a salt thereof, process for its preparation, and its use in the synthesis of elagolix
专利号:CN-117897379-A 优先权日:2021-08-30 标 题:Process for the synthesis of naphthyridine derivatives and intermediates thereof
专利号:WO-2021083554-A1 优先权日:2019-10-30 标题:3-((r)-2-(amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethyl benzyl)-5-iodo-6-methyl-1h-pyrimidine-2,4-dione or a salt thereof, process for its preparation, and its use in the synthesis of elagolix
参考标题:Expeditious Synthesis Of [au(Nhc)(L)]+ (Nhc = N-Heterocyclic Carbene; L = Phosphine Or Nhc) Complexes 作者:Sylvain Gaillard,Pierrick Nun,Alexandra M. Z. Slawin,Steven P. Nolan |发布日期:2010.11.8 摘要:The Use Of The Versatile N-Heterocyclic Carbene (Nhc) Gold(I) Hydroxide [au(Oh)(Ipr)] (Ipr = N,N′-Bis(2,6-Diisopropylphenyl)Imidazol-2-Ylidene) As Precursor Permits The Expedient Synthesis Of A Series Of Cationic Heteroleptic [au(Nhc)(Nhc′)]+ And [au(Nhc)(Pr3)]+ Complexes By Protonolysis With The Appropriate Acid Salts. Complete Characterization By 1H And 13C Nmr Spectroscopy And By Single-Crystal
合成参考文献
摘要:Toffano, M., Science of Synthesis, (2009) 42, 352. 摘要:Methot, J. L.; Roush, W. R., Science of Synthesis, (2009) 42, 476.