CAS: 90843-62-2; 6-Hydroxy-5-Methoxy-2,3-Dihydro-1H-Inden-1-One
该化合物是有机化合物,其特点是双环结构,包括不活动,具有一种有机化合物;该化合物的特点是氢氧基(OH)和甲氧基(OCH3)组,有助于其化学反应和潜在的生物活动;这些功能组的存在表明,该化合物可能具有抗氧化活动等特性,或可作为有机合成的前体;二氢形式表明,该二氢原子在隔热结构的双联体中添加了两种氢原子,可影响其稳定性和再活性;此外,该化合物的溶解性和各种溶剂的行为可因现有分组而不同;该化合物的独特结构还可能允许与生物目标发生相互作用,从而引起对医药化学和药理学的兴趣;有必要进行进一步研究,以充分阐明其特性和潜在用途.
- 英文名称6-Hydroxy-5-Methoxy-2,3-Dihydro-1H-Inden-1-One
- 中文名称6-羟基-5-甲氧基-2,3-二氢-1H-茚-1-酮
- IUPAC名称6-hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-one
- 其它别名Sm1-Zz5 (5-甲氧基-6-羟基-1-茚酮); 6-Hydroxy-5-Methoxy-1-Indanone
- CAS编号90843-62-2
- MFCD编号:MFCD08694213
- EINECS号:103-774-9
- FDA UNII编号:JLK4EG6PQ7
- 分子式:C10H10O3分子量:178.19
- 产品CID: 1942320
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号124702-80-3 5,6-二羟基茚满-1-酮 | CAS号74-88-4 碘甲烷 | CAS号1135-23-5 3-(4-羟基-3-甲氧苯基)丙酸 | CAS号2107-69-9 5,6-二甲氧基-1-茚酮 | CAS号1135-24-6 阿魏酸 | CAS号3199-70-0 6-苄氧基-5-甲氧基-1-茚酮 | CAS号124702-80-3 5,6-二羟基茚满-1-酮合成工艺路线路线简述
- 55417-34-0 = 90843-62-2
反应条件:1.1 Reagents: Thionyl Chloride; 3 H,Reflux1.2 Reagents: Aluminum Chloride Solvents: Dichloromethane; Reflux; 3 H,0 - 5 °C1.3 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; Overnight,Reflux
标题:Truxene Discotic Liquid Crystals With Two Different Ring Substituents: Synthesis,Mesomorphism And High Charged Carrier Mobility
作者:Ni,Hai-Liang; Monobe,Hirosato; Hu,Ping; Wang,Bi-Qin; Shimizu,Yo; Et Al
参考文献:Liquid Crystals 日期:2013 卷标:40(3) 页码:411-420]
1135-23-5 = 90843-62-2
反应条件:1.1 Reagents: Hydrofluoric Acid
标题:Physiologically Active Indanamines. Ii. Compounds Substituted In The Aromatic Ring
作者:Heinzelmann,R. V.; Kolloff,H. G.; Hunter,James H.
参考文献:Journal Of The American Chemical Society 日期:1948 卷标:70 页码:1386-90]
1135-24-6 = 90843-62-2
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 40 °C1.2 Reagents: Methanesulfonic Anhydride; 120 °C
标题:Synthesis,Biological Evaluation And Mechanism Study Of A Class Of Benzylideneindanone Derivatives As Novel Anticancer Agents
作者:Hu,Jinhui; Yan,Jun; Chen,Jie; Pang,Yanqing; Huang,Ling; Et Al
参考文献:Medchemcomm 日期:2015 卷标:6(7) 页码:1318-1327]
1135-23-5 = 90843-62-2
反应条件:1.1 Catalysts: Methanesulfonic Acid; 1 H,120 °C
标题:Design,Synthesis,And Evaluation Of Indanone Derivatives As Acetylcholinesterase Inhibitors And Metal-Chelating Agents
作者:Meng,Fan-Chao; Mao,Fei; Shan,Wen-Jun; Qin,Fangfei; Huang,Ling; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2012 卷标:22(13) 页码:4462-4466]
1135-23-5 = 90843-62-2
反应条件:1.1 Reagents: Methanesulfonic Acid; 1 H,120 °C; 120 °C -> Rt; 5 Min,Cooled
标题:Combining Chalcones With Donepezil To Inhibit Both Cholinesterases And Aβ Fibril Assembly
作者:Chandrika,Nishad Thamban; Fosso,Marina Y.; Tsodikov,Oleg V.; Levine,Harry Iii; Garneau-Tsodikova,Sylvie
参考文献:Molecules 日期:2020 卷标:25(1)]
1135-23-5 = 90843-62-2
反应条件:1.1 Reagents: Methanesulfonic Acid; 1 H,120 °C; 120 °C -> Rt1.2 Reagents: Water; 5 Min,Cooled
标题:Multifunctional Donepezil Analogues As Cholinesterase And Bace1 Inhibitors
作者:Green,Keith D.; Fosso,Marina Y.; Garneau-Tsodikova,Sylvie
参考文献:Molecules 日期:2018 卷标:23(12) 页码:3252/1-3252/22]
1135-23-5 = 90843-62-2
反应条件:1.1 Reagents: Methanesulfonic Acid; 1 H,120 °C
标题:Discovery Of Indanone Derivatives As Multi-Target-Directed Ligands Against Alzheimer'S Disease
作者:Huang,Ling; Miao,Hui; Sun,Yang; Meng,Fanchao; Li,Xingshu
参考文献:European Journal Of Medicinal Chemistry 日期:2014 卷标:87 页码:429-439]
= 90843-62-2
反应条件:1.1 Reagents: Carbon Disulfide,Aluminum Chloride; Rt
标题:Kinetics-Driven Drug Design Strategy For Next-Generation Acetylcholinesterase Inhibitors To Clinical Candidate
作者:Zhou,Yu; Fu,Yan; Yin,Wanchao; Li,Jian; Wang,Wei; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2021 卷标:64(4) 页码:1844-1855]
55417-34-0 = 90843-62-2
反应条件:1.1 Reagents: Aluminum Chloride,Thionyl Chloride Solvents: Dichloromethane1.2 Reagents: Sodium Hydroxide Solvents: Ethanol,Water
标题:The Influence Of Alkyl Chain Substitution Pattern On The Two- And Three-Dimensional Self-Assembly Of Truxenone Discogens
作者:Ruan,Peng; Xiao,Bo; Ni,Hai-Liang; Hu,Ping; Wang,Bi-Qin; Et Al
参考文献:Liquid Crystals 日期:2014 卷标:41(8) 页码:1152-1161]
= 90843-62-2
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dimethylformamide; 0 °C; 24 H,Rt1.2 Reagents: Aluminum Chloride Solvents: Dichloromethane; 0 °C; 3 H,< 15 °C
标题:Synthesis And Mesomorphism Of Ether-Ester Mixed Tail C3-Symmetrical Truxene Discotic Liquid Crystals
作者:Li,Li-Li; Hu,Ping; Wang,Bi-Qin; Yu,Wen-Hao; Shimizu,Yo; Et Al
参考文献:Liquid Crystals 日期:2010 卷标:37(5) 页码:499-506]
= 90843-62-2
反应条件:1.1 Catalysts: L-Proline Solvents: Acetic Acid; 24 H,120 °C
标题:A Metal-Free Method For The Facile Synthesis Of Indanones Via The Intramolecular Hydroacylation Of 2-Vinylbenzaldehyde
作者:He,Guoxue; Ma,Jinyu; Zhou,Jianhui; Li,Chunpu; Liu,Hong; Et Al
参考文献:Green Chemistry 日期:2021 卷标:23(2) 页码:1036-1040]
124702-80-3 = 90843-62-2
反应条件:1.1 Reagents: Lithium Carbonate (Li2Co3) Solvents: Dimethylformamide; 55 °C
标题:Cyanopyridyl Containing 1,4-Dihydroindeno[1,2-C]Pyrazoles As Potent Checkpoint Kinase 1 Inhibitors: Improving Oral Bioavailability
作者:Tong,Yunsong; Przytulinska,Magdalena; Tao,Zhi-Fu; Bouska,Jennifer; Stewart,Kent D.; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2007 卷标:17(20) 页码:5665-5670]
124702-80-3 = 90843-62-2
反应条件:1.1 Reagents: Lithium Carbonate (Li2Co3) Solvents: Dimethylformamide
标题:Synthesis And Biological Evaluation Of 4'-(6,7-Disubstituted-2,4-Dihydro-Indeno[1,2-C]Pyrazol-3-Yl)-Biphenyl-4-Ol As Potent Chk1 Inhibitors
作者:Tao,Zhi-Fu; Li,Gaoquan; Tong,Yunsong; Chen,Zehan; Merta,Philip; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2007 卷标:17(15) 页码:4308-4315]
1135-23-5 = 90843-62-2
反应条件:1.1 Reagents: Methanesulfonic Acid; Rt -> 90 °C
标题:Design,Synthesis,Biological Evaluation And Structural Characterization Of Novel Gebr Library Pde4D Inhibitors
作者:Brullo,Chiara; Rapetti,Federica; Abbate,Sara; Prosdocimi,Tommaso; Torretta,Archimede; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2021 卷标:223]
55417-34-0 = 90843-62-2
反应条件:1.1 Reagents: Thionyl Chloride1.2 Reagents: Aluminum Chloride Solvents: Dichloromethane1.3 Reagents: Sodium Hydroxide Solvents: Ethanol,Water
标题:Effect Of Methoxy Groups On Liquid Crystalline And Self-Assembling Properties Of 2,7,12-Tris(Methoxy)-3,8,13-Tris(Alkoxy)-5,10,15-Truxenones
作者:Xu,Hong-Tian; Xia,Xue; Yu,Wen-Hao; Feng,Chun; Xiang,Shi-Kai; Et Al
参考文献:Liquid Crystals 日期:2021 卷标:48(1) 页码:111-120]
124702-80-3 = 90843-62-2
反应条件:1.1 Reagents: Lithium Carbonate (Li2Co3) Solvents: Dimethylformamide; 3 H,55 °C
标题:Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation,Antioxidant,Metal Chelation,And Monoamine Oxidase B (Mao-B) Inhibition Properties Against Alzheimer'S Disease
作者:Huang,Ling; Lu,Chuanjun; Sun,Yang; Mao,Fei; Luo,Zonghua; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2012 卷标:55(19) 页码:8483-8492
📜3-(4-羟基-3-甲氧基苯基)丙酸置于甲烷磺酸体系中,化学反应 1.0H,以67%的收率获得产物6-羟基-5-甲氧基-1-茚酮
参考文献:查尔酮与多奈哌齐联合抑制胆碱酯酶和 Aβ 原纤维组装
标题:查尔酮与多奈哌齐联合抑制胆碱酯酶和 Aβ 原纤维组装
摘要:患有阿尔茨海默病的人数不断增加,加上治疗该病的药物有限,这一事实强调需要开发新的有效疗法来治疗这种脑部疾病.在此,我们专注于反应生成 12 种查耳酮-多奈哌齐杂合体,目标是同时靶向淀粉样蛋白-β (Aβ) 肽以及胆碱酯酶(即乙酰胆碱酯酶 (Ache) 和丁酰胆碱酯酶 (Bche)).我们介绍了这两个系列新型 1,3-查耳酮-多奈哌齐 (15A-15F) 或 1,4-查耳酮-多奈哌齐 (16A-16F) 杂化物的设计,合成和生化评估.我们评估了它们的结构和抑制 Ache/bche 活性的能力以及结合 Aβ 肽的能力之间的关系.我们表明,其中几种新型查耳酮-多奈哌齐杂合体可以成功抑制 Ache/bche 以及 N-生物素化 Aβ(1-42) 寡聚物的组装.我们还证明这些杂合体的 Aβ 结合位点与匹兹堡化合物 B (Pib) 的不同.
DOI:10.3390/molecules25010077
海关参考信息
- 2902600000-乙苯
2905110000-甲醇
2907210001-间苯二酚
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8580822-B2
优先权日:2006-12-11
标 题:Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
发明人：BHAT LAXMINARAYAN; MOHAPATRA PRABHU PRASAD
权利人:BHAT LAXMINARAYAN; MOHAPATRA PRABHU PRASAD; REVIVA PHARMACEUTICALS INC
摘要:The present invention provides novel indanone derivatives which can be advantageously used for treating and/or preventing of a medical condition for which inhibition of a cholinesterase is desired.
专利号:US-2008153878-A1
优先权日:2006-12-11
标题:Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
专利号:RU-2478619-C2
优先权日:2006-12-11
标 题:Compositions, synthesis and methods of using indanone based cholinesterase inhibitors
专利号:JP-2010512328-A
优先权日:2006-12-11
标题:Composition, synthesis and method of use of indanone cholinesterase inhibitors
专利号:CA-2672212-A1
优先权日:2006-12-11
标 题:Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
专利号:US-8247563-B2
优先权日:2006-12-11
标题 :Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1016/j.bmcl.2012.04.029
摘要:Meng FC, Mao F, Shan WJ, Qin F, Huang L, Li XS. Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents. Bioorg Med Chem Lett. 2012 Jul 01;22(13):4462–6. doi: 10.1016/j.bmcl.2012.04.029.
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尽可能描述清楚需求与问题信息
