CAS: 78964-85-9; Fosfomycin Tromethamine

该化合物是一种主要用于治疗尿道感染的抗生素,是Fosfomycin的衍生物,是一种广泛抗生素,抑制细菌细胞壁合成;Fosfomycyn TRomethamine的化学结构包括一种磷酸化合物组,对于抗菌活动至关重要;一般是作为一种盐状体施用,以提高其溶性性和稳定性;该物质以其快速吸收和排泄为名,允许有效治疗感染;Fosfomytimytroometham是各种抗格抗体和克丁内菌的衍生物,包括抗其他抗生素的菌株;Fosfomycyntomytromotham,其作用包括抑制酶-MurA,这是细菌细胞壁的抗菌合成的关键;这种抗生素一般都具有很强的温度,其副作用较低,在治疗不相容的尿道感染方面是一种宝贵的选择.然而,如同所有抗生素一样,其使用应该以抗性模式来引导,避免发展.

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CAS号855392-18-6 2-amino-2-(hydr... | CAS号26016-99-9 磷霉素钠

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    专利信息


    专利号:US-2024197774-A1
    优先权日:2021-04-16
    标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
    发明人:LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
    权利人:UNIV TEXAS
    摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

    专利号:US-8557979-B2
    优先权日:2004-06-10
    标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
    发明人:CHOI WOO-BAEG; KOWALIK EWA
    权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
    摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

    专利号:US-10933051-B2
    优先权日:2017-06-09
    标 题 :Carbapenem compounds and compositions for the treatment of bacterial infections
    发明人:CHOI WOO-BAEG; TOMIOKA TAKASHI; JOO HYUNG-YEUL; TRUONG PHONG; MIN BRIAN
    权利人:FOB SYNTHESIS INC
    摘要:The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

    专利号:US-9693999-B2
    优先权日:2011-01-26
    标题:Small molecule RNase inhibitors and methods of use
    发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
    权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
    摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

    专利号:US-9937151-B2
    优先权日:2010-06-18
    标题 :Carbapenem antibacterials with gram-negative activity
    发明人:CHOI WOO-BAEG; GRUSZECKA-KOWALIK EWA; JOO HYUNG-YEUL; LIU SHUANGPEI; MAO SHULI; LI YONGFENG; KIM DEOG-IL
    权利人:FOB SYNTHESIS INC
    摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

    专利号:WO-2009056955-A1
    优先权日:2007-10-30
    标题 :Amine-bearing phospholipids (abps), their synthesis and use
    发明人:ZUMBUEHL ANDREAS
    权利人:UNIV BASEL; ZUMBUEHL ANDREAS
    摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.
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    主要参考文献


    1: Los-Arcos I, Pigrau C, Rodríguez-Pardo D, Fernández-Hidalgo N, Andreu A, Larrosa N, Almirante B. Fosfomycin-tromethamine long-term oral therapy for difficult-to-treat chronic bacterial prostatitis. Antimicrob Agents Chemother. 2015 Dec 14. pii: AAC.02611-15. [Epub ahead of print] doi: 10.5173/ceju.2015.590. Epub 2015 Oct 15.
    3: Khan IU, Mirza IA, Ikram A, Ali S, Hussain A, Ghafoor T. In vitro activity of fosfomycin tromethamine against extended spectrum beta-lactamase producing urinary tract bacteria. J Coll Physicians Surg Pak. 2014 Dec;24(12):914-7. doi: 12.2014/JCPSP.914917. doi: 10.1136/bmjopen-2013-004157.
    5: Demir T, Buyukguclu T. Evaluation of the in vitro activity of fosfomycin tromethamine against Gram-negative bacterial strains recovered from community- and hospital-acquired urinary tract infections in Turkey. Int J Infect Dis. 2013 Nov;17(11):e966-70. doi: 10.1016/j.ijid.2013.04.005. Epub 2013 Jun 3. doi: 10.1093/jac/dkn177. Epub 2008 Apr 19. Fosfomycin tromethamine in uncomplicated urinary tract infections: a clinical study. Chemotherapy. 2005 May;51(2-3):162-6. Epub 2005 May 9. doi: 10.1016/j.ijantimicag.2007.11.003. Epub 2008 Jan 3. Turkish. Review. Review. Review.

    合成参考文献


    参考文献:10.2165/00003495-199600522-00006
    摘要:Naber KG. Fluoroquinolones in urinary tract infections. Proper and improper use. Drugs. 1996;52 Suppl 2():27–33. doi: 10.2165/00003495-199600522-00006.
    参考文献:10.2165/00003495-199400473-00003
    摘要:Schito GC, Pesce A, Debbia EA. Stability in the presence of widespread beta-lactamases. A prerequisite for the antibacterial activity of beta-lactam drugs. Drugs. 1994;47 Suppl 3():1–8; discussion 8. doi: 10.2165/00003495-199400473-00003.
    参考文献:10.2165/00003495-199958002-00020
    摘要:Krcméry S, Hromec J, Tvrdikova M, Hassan M, Gulla D. Newer quinolones in the long term prophylaxis of recurrent urinary tract infections (UTI). Drugs. 1999;58 Suppl 2():99–102. doi: 10.2165/00003495-199958002-00020.
    参考文献:10.1007/s192-002-8352-0
    摘要:Ribeiro RM, Rossi P, Pacetta AM, Haddad JM, Pinotti JA. Therapy of uncomplicated urinary tract infections. Int Urogynecol J Pelvic Floor Dysfunct. 2002;13(3):190–4. doi: 10.1007/s192-002-8352-0.
    参考文献:10.1007/s192-002-8354-7
    摘要:Santos JF, Ribeiro RM, Rossi P, Haddad JM, Guidi HG, Pacetta AM, Pinotti JA. Urinary tract infections in pregnant women. Int Urogynecol J Pelvic Floor Dysfunct. 2002;13(3):204–9. doi: 10.1007/s192-002-8354-7.
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