专利号:US-10280189-B2 优先权日:2012-07-17 标题:Method for the synthesis of aminoalkylenephosphonic acid 发明人:BURCK SEBASTIAN; LECLERCQ CEDRIC NICOLAS; NOTTE PATRICK 权利人:MONSANTO TECHNOLOGY LLC 摘要:A method for the synthesis of an aminoalkylenephosphonic acid or its phosphonate esters including the following steps: a) forming, in the presence of an aldehyde or ketone and an acid catalyst, a reaction mixture by mixing a compound having at least one HNR 1 R 2 moiety or a salt thereof, with a compound having one or more P—O—P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V), wherein the ratio of moles of aldehyde or ketone to N—H moieties is 1 or more and wherein the ratio of N—H moieties to P—O—P anhydride moieties is 0.3 or more, and b) recovering the resulting aminoalkylenephosphonic acid having compound or its phosphonate esters.
专利号:US-2004072738-A1 优先权日:2000-12-21 标 题 :Analogues of thiocoraline and be-22179 发明人:BOGER DALE L 摘要:A process for the total synthesis of thiocoraline and BE-22179 establishes the relative and absolute stereochemistry of these compounds and enables the construction and characterization of a series of related analogues. The mechanism for the bioactivity of thiocoraline, BE-22179 and their related analogues is charaterized. Thiocoraline, BE-22179, and their related analogues are disclosed to bind to DNA by high-affinity bisintercalation and are disclosed to exhibit exceptional cytotoxic activity.
专利号:US-7153703-B2 优先权日:2001-05-14 标 题 :Synthesis of stable colloidal nanocrystals using organic dendrons 发明人:PENG XIAOGANG; CHEN HAIYAN 权利人:UNIV ARKANSAS 摘要:A method for stabilizing colloidal suspensions of nanocrystals or nanoparticles in a solvent or solid matrix is provided by coating the nanocrystals with bulky organic molecules, specifically dendrons. By coating nanocrystals with a dense organic dendron coat and further cross-linking the dendron ligands, oxidation of the nanocrystals and dissociation of the ligands are avoided. This invention allows nanocrystals to undergo rigorous purification and processing. It may regularly be applied to a variety of nanocrystals.
专利号:US-3560521-A 优先权日:1967-08-07 标题:Blocking groups for cysteine containing peptides 发明人:MILKOWSKI JOHN D; VEBER DANIEL F; HIRSCHMANN RALPH F 权利人:MERCK & CO INC 摘要:NOVEL PROTECTING GROUPS FOR PEPTIDES CONTAINING A CRYSTEINE RESIDUE. PROCESS FOR THE SYNTHESIS OF PEPTIDES CONTAINING A CYSTEINE RESIDUE WHEREIN THE MERCAPTO FUNCTION OF THE CYSTEINE RESIDUE IS PROTECTED BY A LABILE BLOCKING GROUP. NOVEL INTERMEDIATES USEFUL IN PEPTIDE SYNTHESIS.
专利号:US-3770822-A 优先权日:1967-08-07 标 题 :S-lower alkanoyl- and acetonyl-amino-methylcysteine 发明人:MILKOWSKI J; VEBER D; HIRSCHMANN R 权利人:MERCK & CO INC 摘要:NOVEL PROTECTING GROUPS FOR PEPTIDES CONTAINING A CYTEINE RESIDUE. PROCESS FOR THE SYNTHESIS OF PEPTIDES CONTAINING A CYSTEINE RESIDUE WHEREIN THE MERCAPTO FUNCTION OF THE CYSTEINE RESIDUE IS PROTECTED BY A LABILE BLOCKING GROUP. NOVEL INTERMEDIATES USEFUL IN PEPTIDE SYNTHESIS.
专利号:US-4038306-A 优先权日:1967-08-07 标题 :N-t-butoxycarbonyl-s-lower alkanoylamidomethyl-cysteine and p-nitrophenyl esters 发明人:MILKOWSKI JOHN D; VEBER DANIEL F; HIRSCHMANN RALPH F 权利人:MERCK & CO INC 摘要:Novel protecting groups for peptides containing a cysteine residue. Process for the synthesis of peptides containing a cysteine residue wherein the mercapto function of the cysteine residue is protected by an acetamidomethyl radical or other labile blocking group. Novel intermediates useful in peptide synthesis.
1: Collins FWJ, O'Connor PM, O'Sullivan O, Rea MC, Hill C, Ross RP. Formicin - a novel broad-spectrum two-component lantibiotic produced by Bacillus paralicheniformis APC 1576. Microbiology (Reading). 2016 Sep;162(9):1662-1671. doi: 10.1099/mic.0.000340. Epub 2016 Jul 22. 26(18):3961-3965. doi: 10.1021/acs.orglett.4c01209. Epub 2024 Apr 28. 22(14):5337-5341. doi: 10.1021/acs.orglett.0c01584. Epub 2020 Jul 6. 29:91-8. Spanish. 13(3):135-40. Italian. 33(6):881-5. doi: 10.1128/AAC.33.6.881.
合成参考文献
摘要:Archiv der Pharmazie, 305(427), 1972 [] 摘要:Cha, J. K., Science of Synthesis, (2005) 21, 374. 摘要:Lubell, W. D.; Blankenship, J. W.; Fridkin, G.; Kaul, R., Science of Synthesis, (2005) 21, 741. 摘要:Friestad, G. K., Science of Synthesis, (2009) 40, 100.