CAS: 58483-95-7; 5-Amino-2-Chloropyridine-4-Carboxylic Acid

相似化合物

171178-46-4 907545-47-5 1073182-59-8

上下游产品

5-[N-(tert-butoxycarbonyl)amino]-2-chloropyridine-4-carboxylic acid 6-Chloro-3-pyridinecarboxylic acid tert-butyl (6-chloropyridin-3-yl)carbamate 6-Chloro-pyridin-3-ylamine 6-chloro-3H-pyrido[3,4-d]pyrimidin-4-one pyrimidine4,6-dichloro-pyrido3,4-dpyrimidine 4-chloro-6-(N,N-dimethylamino)-pyrido[3,4-d]pyrimidine H-pyrido[3,4-d]pyrimidin-4-one6-dimethylamino-3H-pyrido[3,4-d]pyrimidin-4-one

5-(N-叔丁氧羰基氨基)-2-氯吡啶置于正丁基锂,四甲基乙二胺,三氟乙酸体系中,用 乙醚,正己烷,二氯甲烷 作为反应溶剂,化学反应 2.0H,反应生成 5-氨基-2-氯吡啶-4-羧酸
参考文献:通过2-取代的5-氨基吡啶衍生物的直接锂化反应合成6-取代的吡啶并[3,4-D]嘧啶-4(3 H)-一
标题:通过2-取代的5-氨基吡啶衍生物的直接锂化反应合成6-取代的吡啶并[3,4-D]嘧啶-4(3 H)-一
摘要:在-10oc下在乙醚中用buli-tmeda对2-取代的5-氨基吡啶的boc或新戊酰基衍生物进行直接锂化,得到4-硫代衍生物,将其用co 2淬灭,得到类似的c-4羧酸.用tfa或koh水溶液水解保护基团,得到2-取代的5-氨基吡啶-4-羧酸,其通过与ch 2反应转化为6-取代的吡啶并[3,4-D]嘧啶-4(3 H)-.甲酰胺,或更理想的是乙酸甲am.boc保护的氨基吡啶提供了最佳的整体效果,这些衍生物的合成最好通过在不添加碱的情况下使氨基吡啶与二碳酸二叔丁酯直接反应来实现.
DOI:10.1039/p19960002221

专利信息

专利号:US-3950160-A
优先权日:1972-09-27
标题:Inhibiting the growth of weeds with 2-substituted pyrdidopyimidines and salts thereof
发明人：ABU EL-HAJ MARWAN J; DOMINY BERYL WILLIAM
权利人:PFIZER
摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.

专利号:US-3962264-A
优先权日:1972-09-27
标 题:Process for making 2-amino nicotinonitrile
发明人：ABU EL-HAJ MARWAN J; DOMINY BERYL WILLIAM
权利人:PFIZER
摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.

专利号:US-3917624-A
优先权日:1972-09-27
标题:Process for producing 2-amino-nicotinonitrile intermediates
发明人：ABU EL-HAJ MARWAN J; DOMINY BERYL WILLIAM
权利人:PFIZER
摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.

专利号:US-3862191-A
优先权日:1972-09-27
标 题 :Pyrido{8 2,3-d{9 pyrimidin-4(3H)-one
发明人：EL-HAJ MARWAN J ABU; DOMINY BERYL WILLIAM
权利人:PFIZER
摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.

专利号:US-2023025807-A1
优先权日:2019-10-30
标题:Cd38 inhibitors
发明人：KULKARNI SANTOSH S; LAGU BHARAT; WU XINYUAN
权利人:MITOBRIDGE INC
摘要:The present invention is directed to a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Compounds of Formula (I) are CD38 inhibitors, which can be used to treat a disease or condition in a subject that benefits from an increase in NAD + or to treat a mitochondrial disorder in a subject. Such disease or condition is a muscle structure disorder, a neuronal activation disorder, a muscle fatigue disorder, a muscle mass disorder, a metabolic disease, a cancer, a vascular disease, an ocular vascular disease, a muscular eye disease, or a renal disease. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 30 to 135; examples 1 to 61; table). Such an exemplary compound is e.g. N-((1r,4r)-4-(2-methoxyethoxy) cyclohexyl)-5-(thiazol-5-yl)-1H-indole-7-carboxamide (II).