CAS: 51766-21-3; Phenyl Phenylphosphoramidochloridate

该化合物是一种属于磷胺类的化学化合物,这种物质通常具有与含磷化合物有关的特性,包括由于氨化物和氯化功能组的存在而具有的潜在反应性,它可能无色,可粉黄液体或固体,取决于其具体配方和纯度;该化合物可能对水分和空气敏感,可能导致水解或退化;其应用可能包括有机合成的使用,特别是用于制作含有磷的中间体或作为各种化学反应的试剂;安全考虑十分重要,因为它可能造成毒性或腐蚀性等危险,需要适当的处理和储存措施;与许多磷化合物一样,它也可能表现出生物活动,需要对其环境和健康影响作进一步调查.

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3848-51-9

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合成工艺路线路线简述

    📜O-Phenyl-N-Phenylphosphoramidate置于五氯化磷体系中,化学反应生成 N-苯基磷氨基氯化苯
    参考文献:有机化学中的磷.第二部分:使用苯基n'-苯基磷酰胺基叠氮酸酯试剂制备nn'二取代芳基脲的新方法.
    标题:有机化学中的磷.第二部分:使用苯基n'-苯基磷酰胺基叠氮酸酯试剂制备nn'二取代芳基脲的新方法.
    摘要:从羧酸,胺和苯基n-苯基磷酰胺基叠氮酸酯中以高收率获得nn'二取代脲.该过程构成了适当的改进的库尔蒂斯反应.
    DOI:10.1016/s0040-4039(01)90424-1

    海关参考信息

    专利信息


    专利号:US-2013190525-A1
    优先权日:2012-01-24
    标题:Synthetic methods pertaining to tert-butyl-benzene-based compounds
    发明人:DELANEY JR JOSEPH THOMAS; SEETHAMRAJU KASYAP; GROSSO PAUL VINCENT
    权利人:BOSTON SCIENT SCIMED INC; BOSTON SCIENT SCIMED INC
    摘要:According to some aspects, the present disclosure pertains to methods of forming dimethyl 5-tert-butylisophthalate which comprise comprising converting 5-tert-butylisophthalic acid into dimethyl 5-tert-butylisophthalate in synthesis procedures that comprises methanol and a dehydrating agent as chemical reagents. In other aspects, the present disclosure pertains to methods of forming 5-tert-butyl-1,3-bis(1-methoxy-1-methylethyl)benzene that comprise deprotonating 5-tert-butyl-1,3-bis(1-hydroxy-1-methylethyl)benzene with a Brønsted-Lowry superbase and methylating the deprotonated 5-tert-butyl-1,3-bis(1-hydroxy-1-methylethyl)benzene to form the 5-tert-butyl-1,3-bis(1-methoxy-1-methylethyl)benzene.

    专利号:RU-2067585-C1
    优先权日:1991-09-12
    标 题 :Derivatives of 5-amino-4-hydroxyhexanoic acid and a method of their synthesis

    专利号:RU-2164229-C2
    优先权日:1994-10-19
    标 题 :Antiviral substrate isoster esters of aspartate protease or their salts, method of their synthesis, pharmaceutical preparation and composition

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: J Parkin, Et Al. Inhibition Of Chymotrypsin By Phenyl N-Phenyl-Phosphoramidochloridate. Biochem Soc Trans. 1992 Aug;20(3):283S.

    合成参考文献


    摘要:Braverman, S.; Cherkinsky, M.; Birsa, M. L., Science of Synthesis, (2005) 18, 263.
    摘要:Keller, P. A., Science of Synthesis, (2007) 20, 618.
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