CAS: 44565-47-1; N-Methyl-2-(Methylamino)Acetamide

相似化合物

51739-63-0 88815-85-4 144332-55-8

上下游产品

CAS号79-04-9 氯乙酰氯 | CAS号74-89-5 氨基甲烷 | CAS号52605-49-9 肌氨酸乙酯盐酸盐 | CAS号105-39-5 氯乙酸乙酯 | CAS号13515-93-0 肌氨酸甲酯盐酸盐 | CAS号64-17-5 乙醇

📜2-氯-N-甲基乙酰胺,甲胺 以 四氢呋喃 作为反应溶剂,化学反应 24.0H,反应生成 N~1~,N~2~-二甲基甘氨酸酰胺
参考文献:The Structure-Activity Profile Of Mercaptobenzamides' Anti-Hiv Activity Suggests That Thermodynamics Of Metabolism Is More Important Than Binding Affinity To The Target
标题:The Structure-Activity Profile Of Mercaptobenzamides' Anti-Hiv Activity Suggests That Thermodynamics Of Metabolism Is More Important Than Binding Affinity To The Target
摘要:Mercaptobenzamide Thioesters And Thioethers Are Chemically Simple Hiv-1 Maturation Inhibitors With A Unique Mechanism Of Action,Low Toxicity,And A High Barrier To Viral Resistance. A Structure-Activity Relationship (Sar) Profile Based On 39 Mercaptobenzamide Prodrug Analogs Exposed Divergent Activity/toxicity Roles For The Internal And Terminal Amides. To Probe The Relationship Between Antiviral Activity And Toxicity,We Generated An Improved Computational Model For The Binding Of Mercaptobenzamide Thioesters (Samts) To The Hiv-1 Ncp7 C-Terminal Zinc Finger,Revealing The Presence Of A Second Low-Energy Binding Orientation,Hitherto Undisclosed. Finally,Using NMR-Derived Thiol-Thioester Exchange Equilibrium Constants,We Propose That Thermodynamics Plays A Role In Determining The Antiviral Activity Observed In The Sar Profile. (C) 2019 Published By Elsevier Masson Sas.
DOI:10.1016/j.Ejmech.2019.06.020

专利信息

专利号:US-11008358-B2
优先权日:2015-03-25
标题:Synthesis of desosamines
发明人：MYERS ANDREW G; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.

专利号:US-2020347087-A1
优先权日:2015-03-25
标题:Synthesis of desosamines

专利号:WO-2016154533-A1
优先权日:2015-03-25
标 题 :Synthesis of desosamines