CAS: 406-81-5; 4-Bromo-1,1,1-Trifluorobutane

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407-67-0 54932-74-0 203303-02-0

上下游产品

CAS号461-18-7 4,4,4-三氟丁醇 | CAS号2623-87-2 4-溴丁酸 | CAS号352-61-4 5,5,5-三氟戊-1-醇 | CAS号128985-16-0 (2R,3R,4R,5S)-2... | CAS号89866-61-5 5,5,5-三氟戊腈

4,4,4-三氟丁醇置于硫酸,氢溴酸体系中,化学反应生成 1-溴-4,4,4-三氟丁烷
参考文献:什么时候三氟甲基比甲基更具亲脂性脂族醇和三氟醇的分配系数和选定的化学位移.
标题:什么时候三氟甲基比甲基更具亲脂性脂族醇和三氟醇的分配系数和选定的化学位移.
摘要:确定了12种三氟甲基化脂肪醇及其非氟化对应物的辛醇-水分配系数.后一个值是在建立适当的相关方程后,使用苯甲醇-水溶剂系统的测量值得出的.附带地,发现了经验方程,其允许在给定分子式和沸点的情况下估计未取代的醇的分配系数.仅当三氟甲基位于α-位时,三氟强烈增强亲脂性.对于β-和γ-(三氟甲基)醇而言,这种增强几乎无法测量,而δ-和ε-(三氟甲基)化合物比其母体化合物具有更大的亲水性.化学位移的比较表明,相对亲脂性的变化主要受三氟甲基对羟基酸碱性的诱导作用控制.提出了用于获得一些醇的新的合成方法.
DOI:10.1002/jps.2600751016

专利信息

专利号:US-2024158826-A1
优先权日:2022-11-16
标 题 :Preparation method of synthetase for continuous monitoring of blood glucose
发明人：ZHANG SHAODA; QIU ZHIPENG; ZHENG XINGYU
权利人:ZHANG SHAODA; QIU ZHIPENG; ZHENG XINGYU
摘要:The present invention discloses a preparation method of a synthetase for continuous monitoring of blood glucose. The method includes the preparation steps of step S1: hydroxylation of a glass bead; step S2: silanization of the glass bead; step S3: bonding of the glass bead to glucose; step S4: synthesis of a polymer particle on the surface of the glass bead to form a glucose synthetase; and step S5: separation of the highly specific glucose synthetase. According to the preparation method of a synthetase for continuous monitoring of blood glucose provided by the present invention, the glass bead is bonded to the glucose by activating the surface of the glass bead, and then bonded to a polymer to form the glucose synthetase. The artificial synthetase prepared by the method has low sensitivity to temperature and pH value, and can be directly used in a blood glucose electrochemical sensor.

专利号:US-5270468-A
优先权日:1992-04-01
标 题 :2- and 3- amino azido derivatives of 1,5-iminosugars
发明人：KHANNA ISH K; MUELLER RICHARD A; WEIER RICHARD M; STEALEY MICHAEL A
权利人:SEARLE & CO
摘要:Novel derivatives of 1-deoxynojirimycin are disclosed which have amino or azido substituents at C-2 and/or C-3. These compounds are useful inhibitors of lentiviruses. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.

专利号:US-8192762-B2
优先权日:2005-06-01
标题 :Preparation of soluble and colloidal molecularly imprinted polymers by living polymerization
发明人：KARIM KHALKU; PILETSKY SERGEY ANATOLIYOVICH; PILETSKA OLENA VOLODIMIRIVNA; TURNER ANTHONY PETER FRANCIS; CHIANELLA IVA; GUERRIERO ANTONIO RICARDO LEONARDO
权利人:KARIM KHALKU; PILETSKY SERGEY ANATOLIYOVICH; PILETSKA OLENA VOLODIMIRIVNA; TURNER ANTHONY PETER FRANCIS; CHIANELLA IVA; GUERRIERO ANTONIO RICARDO LEONARDO; UNIV CRANFIELD
摘要:The present invention describes a method for synthesis of relatively low molecular weight imprinted polymers using living polymerization, and their application in analytical chemistry, pharmacology, medicine and the food industry. Specifically the low-molecular weight polymers are synthesized by the polymerization of functional monomers in the presence of a template, such as a biological receptor, enzyme, nucleic acid, cell, virus, microorganism, tissue sample or drug using living initiator. The conditions of living polymerization ensure a relatively small size of synthesized molecules. Synthesized in this way molecules (dimers, oligomers, polymers, or their mixture) have a higher affinity to the template than the original monomers and can rebind it in vitro and/or in vivo. As a further aspect of the present invention, polymers synthesized as described above can be used as drugs in pharmacology and medicine, as receptor-specific ligands in analytical chemistry (sensors, assays), and for separations in the biotechnology, pharmaceutical and food industries.

专利号:EP-0566557-B1
优先权日:1992-04-01
标题 :2- and 3- amino and azido derivatives of 1,5-iminosugars as antiviral compounds
发明人：KHANNA ISH KUMAR; MUELLER RICHARD AUGUST; WEIER RICHARD MATHIAS; STEALEY MICHAEL ALLAN
权利人:SEARLE & CO
摘要:Novel derivatives of 1-deoxynojirimycin are disclosed which have amino or azido substituents at C-2 and/or C-3. These compounds are useful inhibitors of lentiviruses. Methods of chemical synthesis of these derivatives and intermediates therefor are also disclosed.

专利号:US-9938390-B2
优先权日:2012-11-26
标 题:Method for the preparation of macroporous particles and macroporous microclusters
发明人：STORTI GIUSEPPE; MORBIDELLI MASSIMO; SOOS MIROSLAV; LAMPROU ALEXANDROS; BRAND BASTIAN
权利人:ETH ZUERICH
摘要:A method for producing macro porous micro-clusters is proposed comprising at least the following individual steps in given order: a) synthesis of dispersed cross-linked polymeric latex primary particles starting from at least one monomer or oligomer using emulsion polymerization; b) swelling of the primary particles with a liquid comprising at least an additional charge of monomer and/or oligomer and a cross-linker, optionally further comprising functionalization agents; c) destabilization by increase of ionic strength (by adding a salt and/or acid and/or base) in a combination with application of shear, both being above the gel formation boundary of the phase diagram, until agglomerates composed of primary particles of the desired size are formed; d) polymerization of the agglomerates to form the macro porous micro-clusters. Furthermore the invention to relates to correspondingly produced micro-clusters and uses of such micro-clusters in particular for chromatographic purposes.

专利号:US-6960645-B2
优先权日:2004-03-26
标 题:Synthesis of ion imprinted polymer particles
发明人：RAMAKRISHNAN KALA; JOSEPH MARY G; RAO TALASILA P
权利人:COUNCIL SCIENT IND RES
摘要:Ion imprinted polymer materials are synthesized containing metal ion recognition sites. These particles are synthesized by copolymerizing with functional and cross linking monomers in presence of at least one imprint metal ion in the form of ternary complex. The polymerization was carried out by â–¡-irradiation (in the absence of initiator) or photochemical and thermal polymerization (in presence of initiator, AIBN). These materials were ground and sieved after drying to obtain erbium ion imprinted polymer particles. The erbium ion was removed from the polymer particles by leaching with mineral acid which leaves cavities/binding sites in the polymer particles. The resultant polymer particles can be used as solid phase extractants for selective enrichment of erbium ions from dilute aqueous solutions.