📜1,1-Diethoxyhex-3-Yn-6-Ol置于lindlar'S Catalyst 咪唑,喹啉,正丁基锂,四丁基氟化铵,氢气,碘,三苯基膦,三氟乙酸,Calcium Carbonate体系中,用 四氢呋喃,正己烷,二氯甲烷,乙腈 用作溶剂,化学反应 153.25H,反应生成二十碳五烯酸甲酯
参考文献:Synthesis Of Methyl (5Z,8Z,11Z,14Z,17Z)-And (5Z,8Z,11Z,14Z,17E)-[18-14C] Eicosapentaenoate
标题:Synthesis Of Methyl (5Z,8Z,11Z,14Z,17Z)-And (5Z,8Z,11Z,14Z,17E)-[18-14C] Eicosapentaenoate
摘要:In Order To Have A Better Insight Of The Effect Of The Double Bond Geometry Of Epa On Its Anti-Aggregating Properties,Methyl Ester Of [18-C-14] Epa And Of Its Delta 17T Isomer Were Synthesized From A Common Intermediate [(3Z,6Z,9Z)-12,12-Diethoxydodeca-3,6,9-Trienyl]Triphenylphosphonium Iodide 11 Via Three Sequential Wittig Olelination. Labelled Methyl Ester Of Epa 16B And Epa Delta 17T 17B Were Obtained In Near 100% Isomeric And Radiochemical Purities.
Doi:10.1002/(Sici)1099-1344(199805)41:5<411::Aid-Jlcr94>3.0.Co;2-7