CAS: 23669-79-6; 1-((2R,4S,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxytetrahydrofuran-2-yl)Pyrimidine-2,4(1H,3H)-Dione

相似化合物

40615-39-2 81246-79-9 103285-22-9

上下游产品

2'-deoxyuridine 4,4'-dimethoxytrityl chloride (MeO)2Tr-OAc 4,4'-dimethoxytrityl alcohol Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester DMT-dU-Bn 3'-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione

二(4-甲氧基苯基)(苯基)甲醇置于tetrafluoroboric Acid,Lithium Carbonate,N,N-二异丙基乙胺体系中,用 四氢呋喃,水 用作溶剂,化学反应 0.67H,反应生成保护-2'-脱氧尿苷
参考文献:使用无临时保护基团的 2'-脱氧尿苷向 2'-脱氧胞苷转化改进 5-羟甲基-2'-脱氧胞苷亚磷酰胺的合成
标题:使用无临时保护基团的 2'-脱氧尿苷向 2'-脱氧胞苷转化改进 5-羟甲基-2'-脱氧胞苷亚磷酰胺的合成
摘要:5-羟甲基胞嘧啶最近被定性为人类 Dna 中的"第六个碱基".为了能够对这种 Dna 修饰进行研究,我们报告了一种合成 5-羟甲基-2'-脱氧胞苷 ( 5-Home Dc) 亚磷酰胺的改进方法,用于位点特异性掺入寡核苷酸中.为了最大限度地减少操作,我们采用了一种利用相转移催化的临时无保护基团 2'-脱氧尿苷到 2'-脱氧胞苷的转化过程.所需的5-Home Dc 亚磷酰胺通过 6 个步骤从 2'-脱氧尿苷中获得,总产率为 24%.
Doi:10.1016/j.Bmcl.2010.12.098

专利信息

专利号:WO-2010055207-A1
优先权日:2008-11-17
标题 :Chelating, chelating agents and conjugates deriver thereof
发明人：KETOLA JANNE; HOVINEN JARI
权利人:WALLAC OY; KETOLA JANNE; HOVINEN JARI
摘要:This invention relates to a group of chelating agents, novel chelates, biomolecules labeled with these chelates or chelating agents as well as solid supports conjugated with these chelates, chelating agents and labeled biomolecules. The invention relates also to chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptide conjugates so obtained.