专利号:US-2013338369-A1 优先权日:2011-03-07 标 题 :Process for the Synthesis of Aminobiphenylene 发明人:HEINRICH MARKUS; PRATSCH GERALD 权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE 摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.
专利号:US-2008280855-A1 优先权日:2005-06-22 标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles 发明人:CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO 权利人:NYCOMED GMBH 摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-5783577-A 优先权日:1995-09-15 标题 :Synthesis of quinazolinone libraries and derivatives thereof 发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
专利号:US-6664282-B2 优先权日:1999-09-17 标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds 发明人:ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A 权利人:TORREY PINES INST 摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.
专利号:US-8329880-B2 优先权日:2008-04-25 标 题 :Process for the preparation of naphthalen-2-yl-pyrazol-3-one intermediates useful in the synthesis of sigma receptor inhibitors 发明人:JOVER ANTONI TORRENS; ARJONA JORDI CORBERA; CUBERES-ALTISENT MARIA ROSA 权利人:JOVER ANTONI TORRENS; ARJONA JORDI CORBERA; CUBERES-ALTISENT MARIA ROSA; ESTEVE LABOR DR 摘要:The invention relates to a process for preparing naphthalen-2-yl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors.
[参考文献]: Erman Je, Et, Al. Peroxygenase Activity Of Cytochrome C Peroxidase And Three Apolar Distal Heme Pocket Mutants: Hydroxylation Of 1-Methoxynaphthalene. Bmc Biochem. 2013 Jul 30;14:19. [参考文献]: Shindo K, Et, Al. Production Of Novel Antioxidative Prenyl Naphthalen-Ols By Combinational Bioconversion With Dioxygenase Phna1A2A3A4 And Prenyltransferase Nphb Or Sco7190. Biosci Biotechnol Biochem. 2011;75(3):505-10. [参考文献]: Kazutoshi Shindo, Et Al. Production Of Novel Antioxidative Prenyl Naphthalen-Ols By Combinational Bioconversion With Dioxygenase Phna1A2A3A4 And Prenyltransferase Nphb Or Sco7190. Biosci Biotechnol Biochem. 2011;75(3):505-10.
合成参考文献
摘要:Toyota, S.; Iwanaga, T., Science of Synthesis, (2010) 45, 783. 摘要:Suginome, M.; Ohmura, T., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 168. 摘要:Inamoto, K., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 424. 摘要:Molander, G. A.; Ryu, D., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 56. 摘要:Dai, X.; Shi, F., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 1, 135.