CAS: 18592-13-7; 6-(Chloromethyl)Pyrimidine-2,4(1H,3H)-Dione

相似化合物

626-48-2 22126-44-9 18592-13-7

上下游产品

CAS号22126-44-9 6-(羟甲基)尿嘧啶 | CAS号638-07-3 4-氯乙酰乙酸乙酯 | CAS号57-13-6 尿素 | CAS号89639-37-2 6-(氯甲基)-2-(甲基硫代... | CAS号626-48-2 6-甲基尿嘧啶 | CAS号36327-91-0 6-甲酰尿嘧啶 | CAS号110-86-1 吡啶 | CAS号41295-64-1 4-chloro-3-oxob... | CAS号183205-46-1 5-bromo-6-(chlo... | CAS号184778-07-2 6-[(tridecylami... | CAS号29410-13-7 5-hydroxyimidaz... | CAS号124443-51-2 2,4-Imidazolidi... | CAS号79-11-8 氯乙酸 | CAS号31777-62-5 N-((1,2,3,6-四氢-... | CAS号162284-62-0 6-(CHLOROMETHYL... | CAS号138449-02-2 6-[(°Ctadecylam... | CAS号69774-56-7 Acetic acid,2-[... | CAS号73541-53-4 4-[(2,6-dioxo-3...

乳清酸置于sodium Tetrahydroborate,氯化亚砜,N,N-二甲基甲酰胺,Calcium Chloride体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 20.0H,反应生成6-(氯甲基)脲嘧啶
参考文献:一种6-氯甲基尿嘧啶的合成方法
标题:一种6-氯甲基尿嘧啶的合成方法
摘要:本发明公开了一种6‑氯甲基尿嘧啶的合成方法,包括以下步骤:(1)酯化反应:将乳清酸加入无水甲醇中,滴加二氯亚砜,反应6小时,蒸干溶剂,加入有机溶剂,室温搅拌,抽滤,干燥得乳清酸甲酯;(2)还原反应:将乳清酸甲酯溶于无水甲醇中,加入路易斯酸,加入硼氢化钠,室温搅拌12~16小时,用冰乙酸中和,蒸干溶剂,加入有机溶剂,室温搅拌,抽滤,干燥,得6‑羟甲基尿嘧啶;(3)氯代反应:将6‑羟甲基尿嘧啶加入到有机溶剂中,加入二氯亚砜和催化量n,N‑二甲基甲酰胺,反应2小时,降至室温,抽滤,干燥,得6‑氯甲基尿嘧啶.本发明的合成方法,避免了剧毒试剂的使用,反应条件温和,原料价廉易得,收率较高,有利于工业化生产.

专利信息

专利号:US-11028057-B2
优先权日:2018-02-28
标题:Process for the synthesis of 6-chloromethyluracil
发明人：MORANA FABIO; GOBBATO STEFANO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:The invention relates to a process for the synthesis of 6-chloromethyluracil (6-(chloromethyl)pyrimidin-2,4(1H,3H)-dione) from ethyl 4-chloroacetoacetate and S-methylisothiourea hemisulfate via isolation of the novel intermediate 6-(chloromethyl)-6-hydroxy-2-(methylthio)-5,6-dihydropyrimidin-4(1H)-one, and its subsequent treatment with aqueous sulfuric acid. Formula (I).

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:EP-3759082-B1
优先权日:2018-02-28
标题 :Process for the synthesis of 6-chloromethyluracil

专利号:IT-201800003134-A1
优先权日:2018-02-28
标 题:PROCESS FOR THE SYNTHESIS OF 6-CHLOROMETHYLURACIL

专利号:PT-3759082-T
优先权日:2018-02-28
标题 :PROCESS FOR THE SYNTHESIS OF 6-CHLOROMTHYLURACYL

专利号:US-2020407330-A1
优先权日:2018-02-28
标 题:Process for the synthesis of 6-chloromethyluracil