CAS: 1628106-94-4; (3R)-3-((R)-2-Cyclopentyl-2-Hydroxy-2-Phenylacetoxy)-1-(2-Ethoxy-2-Oxoethyl)-1-Methylpyrrolidin-1-Ium Bromide
- 英文名称(3R)-3-((R)-2-Cyclopentyl-2-Hydroxy-2-Phenylacetoxy)-1-(2-Ethoxy-2-Oxoethyl)-1-Methylpyrrolidin-1-Ium Bromide
- 中文名称(3R)-3-((R)-2-环戊基-2-羟基-2-苯基乙酰氧基)-1-(2-乙氧基-2-氧乙基)-1-甲基吡咯烷-1-咪唑溴化铵
- IUPAC名称(3R)-3-((R)-2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium bromide
- 其它别名Pyrrolidinium, 3-(((2R)-2-Cyclopentyl-2-Hydroxy-2-Phenylacetyl)Oxy)-1-(2-Ethoxy-2-Oxoethyl)-1-Methyl-, Bromide (1:1), (3R)- | Sofpironium Bromide [usan] | Sofpironium (Bromide) | (3R)-3-((R)-2-Cyclopentyl-2-Hydroxy-2-Phenylacetoxy)-1-(2-Ethoxy-2-Oxoethyl)
- CAS编号1628106-94-4
- MFCD编号:MFCD34469175
- FDA UNII编号:7B2Y1932XU
- 分子式:C22H32BrNO5分子量:470.4
- 产品CID: 824202
- 同类组份化合物CAS1628251-49-9 (cation)1628106-94-4 (bromide)2409055-48-5 (tosylate)
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海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2905122000-异丙醇
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主要参考文献
1: Kirsch B, Smith S, Cohen J, DuBois J, Green L, Baumann L, Bhatia N, Pariser D, Liu PY, Chadha D, Walker P. Efficacy and safety of topical sofpironium bromide gel for the treatment of axillary hyperhidrosis: A phase II, randomized, controlled, double-blinded trial. J Am Acad Dermatol. 2020 Jun;82(6):1321-1327. doi: 10.1016/j.jaad.2020.02.016. Epub 2020 Feb 15. 161(10):363-373. Hungarian. doi: 10.1556/650.2020.31657. 80(18):1981-1986. doi: 10.1007/s40265-020-01438-1. 48(3):279-288. doi: 10.1111/1346-8138.15668. Epub 2021 Jan 7.
5: Hobart J, Burke L, Kirsch B, Chadha D. Hyperhidrosis Disease Severity Measure-Axillary (HDSM-Ax): Evaluation of Measurement Performance. J Drugs Dermatol. 2021 Apr 1;20(4):410-418. doi: 10.36849/JDD.2021.5569. 48(8):1149-1161. doi: 10.1111/1346-8138.15927. Epub 2021 May 26.
7: Gregoriou S, Tsiogka A, Kontochristopoulos G, Offidani A, Campanati A. Sofpironium bromide: an investigational agent for the treatment of axillary hyperhidrosis. Expert Opin Investig Drugs. 2022 Jan;31(1):15-21. doi: 10.1080/13543784.2022.2017880. Epub 2021 Dec 22. 21(4):s5-s10. 49(6):594-599. doi: 10.1111/1346-8138.16384. Epub 2022 Apr 8. Erratum in: J Dermatol. 2022 Aug;49(8):800. doi: 10.1111/1346-8138.16511.
合成参考文献
摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).
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