专利号:US-2023137160-A1 优先权日:2020-03-31 标 题 :Large scale process for preparing 1,2,4, 6-tetra-o-acetyl-3-azido-3-deoxy-d-galactopyranoside 发明人:NILSSON ULF; CUMMINS JONATHAN 权利人:GALECTO BIOTECH AB 摘要:A process for preparing a compound of formula (X) n n n n n n n n n n The process includes reacting a compound of formula (IX) n n n n n n n n n n with an acetylating agent in the presence of a base in a suitable solvent and at a suitable temperature for a sufficient reaction time for preparing the compound of formula X. The process is suitable for large scale synthesis.
专利号:US-8846910-B2 优先权日:2006-08-22 标题:Matrix metalloproteinase inhibitors 发明人:SATTIGERI VISWAJANANI J; PALLE VENKATA P; KHERA MANOJ KUMAR; REDDY RANADHEER; TIWARI MANOJ KUMAR; SONI AJAY; RAUF ABDUL REHMAN ABDUL; JOSEPH SONY; MUSIB ARPITA; DASTIDAR SUNANDA G; SRIVASTAVA PUNIT KUMAR 权利人:RANBAXY LAB LTD 摘要:The present invention relates to β-hydroxy and amino-substituted carboxylic acids, which act as matrix metalloproteinase inhibitors, particularly diastereomerically pure β-hydroxy carboxylic acids, corresponding processes for their synthesis, and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune, and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase.
参考标题:The Rapid Synthesis Of Deoxyfluoro Sugars Using Tris(Dimethylamino)Sulfonium Difluorotrimethylsilicate (Tasf) 作者:Bogdan Doboszewski,George W. Hay,Walter A. Szarek |发布日期:1987.2.1 摘要:Deoxyfluoro Sugars Were Synthesized Rapidly By The Reaction Of Trifluoromethanesulfonyl Derivatives Of Partially Protected Sugars With Tris(Dimethylamino)Sulfonium Difluorotrimethylsilicate (Tasf) Under Mild Conditions. The Displacements Occurred With Inversion Of Configuration; Fluorine Has Been Introduced Stereospecifically At Each Of The Secondary Alcoholic Sites Of Aldohexopyranosides And In One