CAS: 1352492-08-0; Methyl 4'-(Dibromomethyl)-[1,1'-Biphenyl]-2-Carboxylate
- 英文名称Methyl 4'-(Dibromomethyl)-[1,1'-Biphenyl]-2-Carboxylate
- 中文名称二溴杂质
- IUPAC名称methyl 4'-(dibromomethyl)-[1,1'-biphenyl]-2-carboxylate
- 其它别名Telmisartan Impurity Methyl 4'-(Dibromomethyl)Biphenyl-2-Carboxylate; Methyl 4'-(Dibromomethyl)-2-Biphenylcarboxylate; 4A€,4-(Dibromomethyl)-[1,1-Biphenyl]-2-Carboxylic Acid Methyl Ester; [1,1'-Biphenyl]-2-Carboxylic Acid, 4'-(Dibromomethyl)-, Methyl Ester; Methyl4'-(Dibromomethyl)-[1,1'-Biphenyl]-2-Carboxylate; Telmisartan-Dibromo Methyl Ester; Dibromo Impurity
- CAS编号1352492-08-0
- MFCD编号:MFCD21363863
- FDA UNII编号:G6JM3R3VFY
- 分子式:C15H12Br2O2分子量:384.07
- 产品CID: 537804
- 产品分类有机原料 → 苯类化合物 → 苯取代衍生物
MSDS等安全信息
上下游产品
4'-甲基联苯-2-羧酸甲酯 Methyl 4'-Methylbiphenyl-2-Carboxylate 114772-34-8合成工艺路线路线简述
📜4'-甲基联苯-2-羧酸甲酯置于1,3-二溴-5,5-二甲基海因,偶氮二异丁腈体系中,用 氯仿 用作溶剂,以92.6%的收率获得4'-溴甲基-2-甲酸甲酯联苯
参考文献:An Efficient And Impurity-Free Process For Telmisartan: An Antihypertensive Drug
标题:An Efficient And Impurity-Free Process For Telmisartan: An Antihypertensive Drug
摘要:Telmisartan (1),A Substituted Dibenzimidazole Derivative,Is An Antihypertensive Drug,Essentially Used To Control Blood Pressure. An Improved,Cost-Effective,And Impurity-Free Process For Telmisartan (1) Suitable For Large-Scale Production Is Described Here By Addressing Various Process Development Issues. The Overall Yield Obtained From This Newly Developed Process Is Around 50% (Over Five Steps) Compared To The Literature Reported Process (21%,Over Eight Steps).
Doi:10.1021/op060200G
海关参考信息
- 2906210000-苄醇
2912110000-甲醛
2912210000-苯甲醛
2915110000-甲酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11566004-B2
优先权日:2018-07-23
标题 :Process for the preparation of bromodomain inhibitor
发明人：TRAVERSE JOHN FITZGERALD; YONG KELVIN HIN-YEONG; FERRETTI ANTONIO CHRISTIAN; ALITE HEKLA; MOSELEY JONATHAN; RUDA ANTONIO MARIA; PRIMER DAVID; PHILP STEVEN
权利人:CELGENE QUANTICEL RES INC
摘要:The present invention provides processes of synthesis and purification of a bromodomain inhibitor, Compound 1, which compound includes crystalline forms, amorphous forms, solvates, and hydrates thereof. Embodiments of the disclosure relate to chemical synthesis routes of Compound 1 that provide a scalable method that results in highly pure final product. A further embodiment relates to methods to isolate the most stable polymorph of Compound 1 by crystallization from formic acid and water.
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优先权日:2025-01-08
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优先权日:2024-06-18
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