CAS: 114262-49-6; 1-((2R,3S,4R,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)-3-Methyltetrahydrofuran-2-yl)Pyrimidine-2,4(1H,3H)-Dione

专利信息

专利号:US-10160779-B2
优先权日:2015-06-22
标 题 :Synthesis of phosphoramidates
发明人：SCHÖNE OLGA; WILHELM THORSTEN
权利人:SANDOZ AG
摘要:A process for preparing a compound of formula (I) or a salt thereof, the process comprising providing a compound of formula (III) wherein PG is an inert electron withdrawing hydroxyl protecting group, reacting the compound of formula (III) with a fluorinating agent, obtaining a compound of formula (II) and deprotecting the compound of formula (II).

专利号:US-2018162896-A1
优先权日:2015-05-26
标题 :Synthesis of Phosphoramidates
发明人：WILHELM THORSTEN; SCHÖNE OLGA; SPITZENSTÄTTER HANS-PETER
权利人:SANDOZ AG
摘要:A process for preparing a nucleoside phosphoramidate, in particular to a process for preparing sofosbuvir, wherein a phosphoramidate derivative is used as starting material.

专利号:US-2018298045-A1
优先权日:2015-06-22
标 题:Synthesis of Phosphoramidates

专利号:WO-2016189040-A1
优先权日:2015-05-26
标题:Selective process for synthesis of nucleoside phosphoramidates