📜5,4''-二羟基-6,7,8-三甲氧基黄酮置于盐酸体系中,用 甲醇,水 作为反应溶剂,化学反应 52.0H,反应生成 5,8-二羟基-2-(4-羟基苯基)-6,7-二甲氧基-4H-1-苯并吡喃-4-酮 参考文献:Tlc,Uv And Acidic Treatment In The Differentiation Of 5,6-And 5,8-Dihydroxyflavones,3-Methoxyflavones And Flavonols 标题:Tlc,Uv And Acidic Treatment In The Differentiation Of 5,6-And 5,8-Dihydroxyflavones,3-Methoxyflavones And Flavonols 摘要: DOI:10.1016/s0040-4020(01)91379-1
专利号:US-7598291-B2 优先权日:2004-09-02 标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-2010160244-A1 优先权日:2004-09-02 标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
参考标题:Synthesis Of 5,8-Dihydroxy-6,7-Dimethoxyflavones And Revised Structures For Some Natural Flavones 作者:T Horie |发布日期:1995.7 摘要:7-Trimethoxyflavones Were Synthesized From 2′,5′-Dihydroxy-3′,4′,6′-Trimethoxyacetophenone By Adapting The Selective O -Alkylation And Dealkylation, And The Differentiation Between The Flavones And Their Isomeric 6-Hydroxyflavones Was Clarified By 1 H Nmr And Uv Spectra. Four Natural Flavones Proposed As 5,8-Dihydroxy-6,7-Dimethoxyflavones, Must Have Other Structures And Three Are Shown To Be The Isomeric
合成参考文献
参考文献:10.1021/jf980936f 摘要:Wang H, Nair MG, Strasburg GM, Booren AM, Gray JI. Antioxidant Polyphenols from Tart Cherries (Prunus cerasus). J. Agric. Food Chem. 1999 Jan 21;47(3):840–4. doi: 10.1021/jf980936f.