CAS: 94838-55-8; 4-(N-Boc-Aminomethyl)Aniline

该化合物是有机化合物,其特点是氨基苯基化合物功能组,其特征为:其有机化合物;其特性为:一个叔丁基乙基混合物,其分支为烷基烷基化合物,以其不育障碍闻名,有助于该化合物在有机溶剂中的稳定性和溶解性;4-氨基基苯甲基苯酸混合物的存在表明,该产品含有一个与苯基碳相连的氨基氨基化合物组,该物质可参与各种化学反应,包括核循环替代和混合反应;该化合物通常用于有机合成,可作为生产药品或农用化学品的一个中间体;其性质包括氨基和氨基酯基化合物的中度极性,这可影响该化合物的再活动以及与生物系统的互动;在处理时,应参考安全数据,与任何化学物质一样,以确保在使用过程中采取适当的防范措施.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号94838-58-1 N-B°C-4-硝基苯乙胺 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号4403-71-8 4-氨基苄胺 | CAS号18600-42-5 4-硝基苄胺盐酸盐 | CAS号7409-30-5 4-硝基苄胺 | CAS号619-73-8 对硝基苯甲醇 | CAS号39628-94-9 4-硝基苄基 甲磺酸酯 | CAS号62133-07-7 2-(4-硝基苄基)异二氢吲哚... | CAS号619-72-7 对硝基苯甲腈 | CAS号129872-50-0 4-(Methylsulfon... | CAS号89631-74-3 4-(B°C-氨基甲基)苯基异硫氰酸酯

合成工艺路线路线简述

  • 24424-99-5 + 4403-71-8 = 94838-55-8
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: 1,4-Dioxane; Rt; 10 H,Rt
    标题:Preparation Of O-Pyrrolidinyl Benzamide Compound
    参考文献:China]

    24424-99-5 + 4403-71-8 = 94838-55-8
    反应条件:1.1 Solvents: Ethyl Acetate; 30 Min,0 °C; 18 H,23 °C
    标题:Novel Bis-Amide Containing Compounds Exhibiting Antifungal Activity And Their Method Of Use And Preparation
    参考文献:World Intellectual Property Organization]

    24424-99-5 + 4403-71-8 = 94838-55-8
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; Rt -> 0 °C1.2 0 °C; 2 H,0 °C
    标题:Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control Of Inhibition In Vitro And Enable Restoration Of Cognition In An Alzheimer'S Disease Mouse Model Upon Irradiation
    作者:Scheiner,Matthias; Sink,Alexandra; Hoffmann,Matthias; Vrigneau,Cassandre; Endres,Erik; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2022 卷标:144(7) 页码:3279-3284]

    24424-99-5 + 4403-71-8 = 94838-55-8
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; Rt -> 0 °C1.2 Solvents: Dichloromethane; 0 °C; 2 H,0 °C
    标题:"Photo-Rimonabant": Synthesis And Biological Evaluation Of Novel Photoswitchable Molecules Derived From Rimonabant Lead To A Highly Selective And Nanomolar "Cis-On" Cb1R Antagonist
    作者:Rodriguez-Soacha,Diego A.; Fender,Julia; Ramirez,Yesid A.; Collado,Juan Antonio; Munoz,Eduardo; Et Al
    参考文献:Acs Chemical Neuroscience 日期:2021 卷标:12(9) 页码:1632-1647]

    94838-58-1 = 94838-55-8
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 3 H,50 Psi,Rt
    标题:Preparation Of Benzazepines,Benzodiazepines,And Analogs As Fibrinogen Antagonists
    参考文献:United States]

    94838-58-1 = 94838-55-8
    反应条件:1.1 Reagents: Nickel Dichloride,Sodium Borohydride Solvents: Methanol; 30 Min,0 °C; 15 Min,0 °C
    标题:Preparation Of Peptidyl Antithrombotic Agents
    参考文献:United States]

    24424-99-5 + 4403-71-8 = 94838-55-8
    反应条件:1.1 Solvents: Tetrahydrofuran
    标题:Photoswitchable Amino Acids - Synthesis,Photochromism And Incorporation Into Peptidic Grb2-Sh2 Antagonists
    作者:Priewisch,Beate
    参考文献:2006]

    24424-99-5 + 4403-71-8 = 94838-55-8
    反应条件:1.1 Solvents: Tetrahydrofuran; 2 H,Rt
    标题:N-(3-Acyloxy-2-Benzylpropyl)-N'-[4-(Methylsulfonylamino)Benzyl]Thiourea Analogues: Novel Potent And High Affinity Antagonists And Partial Antagonists Of The Vanilloid Receptor
    作者:Lee,Jeewoo; Lee,Jiyoun; Kang,Myungshim; Shin,Myoungyoup; Kim,Ji-Min; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2003 卷标:46(14) 页码:3116-3126]

    24424-99-5 + 4403-71-8 = 94838-55-8
    反应条件:1.1 Reagents: Triethylamine Solvents: 1,4-Dioxane,Water; Cooled; 18 H,Rt
    标题:Preparation Of (Sulfonylamino)(Aminomethylidene)Indolinones As Cell Proliferation Inhibitors.
    参考文献:World Intellectual Property Organization]

    24424-99-5 + 4403-71-8 = 94838-55-8
    反应条件:1.1 Solvents: Tetrahydrofuran; 2 H,Rt
    标题:Preparation Of Novel Thioureas As Modulators For Vanilloid Receptor (Vr)
    参考文献:World Intellectual Property Organization]

    24424-99-5 + 4403-71-8 = 94838-55-8
    反应条件:1.1 Catalysts: 1-Butyl-3-Methylimidazolium Bis(Trifluoromethylsulfonyl)Imide; 1 Min,30 - 35 °C
    标题:Nonsolvent Application Of Ionic Liquids: Organo-Catalysis By 1-Alkyl-3-Methylimidazolium Cation Based Room-Temperature Ionic Liquids For Chemoselective N-Tert-Butyloxycarbonylation Of Amines And The Influence Of The C-2 Hydrogen On Catalytic Efficiency
    作者:Sarkar,Anirban; Roy,Sudipta Raha; Parikh,Naisargee; Chakraborti,Asit K.
    参考文献:Journal Of Organic Chemistry 日期:2011 卷标:76(17) 页码:7132-7140]

    94838-58-1 = 94838-55-8
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 2 H,35 Psi,Rt
    标题:New Indolylarylsulfones As Highly Potent And Broad Spectrum Hiv-1 Non-Nucleoside Reverse Transcriptase Inhibitors
    作者:Famiglini,Valeria; La Regina,Giuseppe; Coluccia,Antonio; Pelliccia,Sveva; Brancale,Andrea; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2014 卷标:80 页码:101-111]

    94838-58-1 = 94838-55-8
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl Acetate; 3 H,1 Atm,Rt
    标题:Tricyclic Indole-2-Carboxylic Acids: Highly In Vivo Active And Selective Antagonists For The Glycine Binding Site Of The Nmda Receptor
    作者:Katayama,Seiji; Ae,Nobuyuki; Kodo,Toru; Masumoto,Shuji; Hourai,Shinji; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2003 卷标:46(5) 页码:691-701]

    24424-99-5 + 4403-71-8 = 94838-55-8
    反应条件:1.1 Solvents: Tetrahydrofuran; Rt; 90 Min,Rt
    标题:Preparation Of Selective Npy (Y5) Antagonists And Pharmaceutical Compositions Thereof For Treating An Abnormality Modulated By Human Y5 Receptor Activity.
    参考文献:World Intellectual Property Organization]

    94838-58-1 = 94838-55-8
    反应条件:1.1 Reagents: Iron,Ammonium Chloride Solvents: Ethanol,1,4-Dioxane,Water; 4 H,70 °C; 70 °C -> 25 °C
    标题:Preparation Of Sulfonyl Amide Derivatives For The Treatment Of Abnormal Cell Growth
    参考文献:World Intellectual Property Organization]

    24424-99-5 + 4403-71-8 = 94838-55-8
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 °C; 0 °C -> Rt; Overnight,Rt
    标题:New Amidine-Benzenesulfonamides As Inos Inhibitors For The Therapy Of The Triple Negative Breast Cancer
    作者:Carrion,M. Dora; Rubio-Ruiz,Belen; Franco-Montalban,Francisco; Amoia,Pasquale; Zuccarini,Maria Chiara; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2023 卷标:248]

    94838-58-1 = 94838-55-8
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol,Dichloromethane; 2 D,Rt
    标题:Oxidative Approach Enables Efficient Access To Cyclic Azobenzenes
    作者:Maier,Martin S.; Huell,Katharina; Reynders,Martin; Matsuura,Bryan S.; Leippe,Philipp; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2019 卷标:141(43) 页码:17295-17304]

    94838-58-1 = 94838-55-8
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl Acetate; 1 H,Rt
    标题:Azobenzene-Based Chloride Transporters With Light-Controllable Activities
    作者:Choi,Ye Rin; Kim,Gyu Chan; Jeon,Hae-Geun; Park,Jinhong; Namkung,Wan; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2014 卷标:50(97) 页码:15305-15308]

    24424-99-5 + 4403-71-8 = 94838-55-8
    反应条件:1.1 Solvents: Dichloromethane; Rt; 2 H,Rt
    标题:Chloride Transport Activities Of Trans- And Cis-Amide-Linked Bisureas
    作者:Park,Eun Bit; Jeong,Kyu-Sung
    参考文献:Chemical Communications (Cambridge 日期:2015 卷标:51(44) 页码:9197-9200]

    24424-99-5 + 4403-71-8 = 94838-55-8
    反应条件:1.1 Solvents: Tetrahydrofuran; Rt; 3 H,Rt
    标题:Preparation Of Substituted Pyrimidinamines As Small Molecule Inhibitors Of Oncogenic Chd1L With Preclinical Activity Against Colorectal Cancer
    参考文献:World Intellectual Property Organization
📜对硝基苯甲腈置于palladium On Activated Charcoal,氢气,N,N-二异丙基乙胺,Diborane(6)体系中,用 四氢呋喃,甲醇,二氯甲烷 作为反应溶剂,化学反应 3.5H,反应生成 4-(N-Boc-氨甲基)苯胺
参考文献: Benzazepine Dicarboxamide Compounds With Tertiary Amide Function[fr] Composés De Benzazépine Dicarboxamide à Fonction Amide Tertiaire
标题: Benzazepine Dicarboxamide Compounds With Tertiary Amide Function[fr] Composés De Benzazépine Dicarboxamide à Fonction Amide Tertiaire
摘要:这项发明涉及新的苯并氮杂环二羧酰胺化合物,其化学式为(i),其中r1至r3如描述和权利要求中所定义,并且其药学上可接受的盐.这些化合物是tlr激动剂,因此可能用作治疗癌症,自身免疫疾病,炎症,败血症,过敏,哮喘,移植排斥,移植物抗宿主病,免疫缺陷和传染病等疾病的药物.

海关参考信息

专利信息


专利号:WO-2025101716-A1
优先权日:2023-11-07
标题:Processes for synthesis of trifunctionalized sulfur(vi) compounds
发明人：LOPCHUK JUSTIN; SHULTZ ZACHARY; ATHAWALE PARESH
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure describes processes for the asymmetric synthesis of trifunctionalized sulfur(VI) containing organic compounds of Formula I and Formula VI, as well as compounds of Formula I and Formula VI prepared by the processes described.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2022143183-A1
优先权日:2019-02-23
标题:Photoswitchable protacs and synthesis and uses thereof
发明人：TRAUNER DIRK; REYNDERS MARTIN; MATSUURA BRYAN; BEROUTI MARLEEN; PAGANO MICHELE
权利人:UNIV NEW YORK
摘要:Provided are compounds, which may be referred to as PHOTACs (photoswitchable proteolysis targeting chimeras), and compositions, kits, and methods of making and using PHOTACs. PHOTACs have one or more E3 ligase ligand(s), one or more photoswitchable group(s), optionally, one or more linker(s), and one or more ligand(s) for a target protein. PHOTACs may be suitable for use in methods to treat diseases, such as, for example, cancer. PHOTACs may also be suitable for use in methods to induce selective degradation of a target protein.

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主要参考文献

[参考文献]: Maja Khn, Et Al. Staudinger Ligation: A New Immobilization Strategy For The Preparation Of Small-Molecule Arrays. Angew Chem Int Ed Engl. 2003;42(47):5830-4.

合成参考文献


摘要:Rück-Braun, K.; Priewisch, B., Science of Synthesis, (2007) 31, 1340.
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