CAS: 86541-78-8; (S)-2-(((S)-1-(Carboxymethyl)-2-Oxo-2,3,4,5-Tetrahydro-1H-Benzo[b]Azepin-3-yl)Amino)-4-Phenylbutanoic Acid

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CAS号86541-77-7 盐酸贝那普利 | CAS号4424-80-0 1,3,4,5-四氢-2H-1... | CAS号86499-22-1 3,3-二氯-2,3,4,5-... | CAS号86499-23-2 α-氯代苯并己内酰胺 | CAS号86499-53-8 (3S)-3-amino-1-... | CAS号86499-52-7 (S)-3-Amino-2,3...

📜盐酸贝那普利置于sodium Hydroxide体系中,化学反应 0.5H,反应生成 贝那普利拉
参考文献:开发和验证不同方法处理零级和一级光谱测定部分重叠的混合物苯那普利和氨氯地平的比较研究
标题:开发和验证不同方法处理零级和一级光谱测定部分重叠的混合物苯那普利和氨氯地平的比较研究
摘要:已经开发了三种简单,选择性和准确的分光光度法,然后经过验证可用于散装散剂和药物剂型中的贝那普利(benz)和氨氯地平(aml)的分析.第一种方法是零阶吸收系数(af)和一阶光谱的幅度系数(pf),其中benz和aml均可从其在238 Nm处解析的零阶光谱或在253 Nm处的一阶光谱进行测量.第二种方法是针对零阶的常数乘法与恒定减法(cm-Cs)以及针对一阶光谱的连续导数减法-常数乘法(sds-Cm),其中benz和aml均可从其解析的零阶光谱中进行测量分别在240 Nm和238 Nm 或分别来自benazepril和amlodipine在214 Nm和253 Nm的一级光谱.第三种方法是新颖的常数乘积与导数零交叉(cm-Dzc)结合,这是一种在存在苯那普利主要降解产物贝那普利特(benzt)的情况下测定贝那普利和氨氯地平的稳定性指示测定方法.三种方法均按照ich指南进行了验证,贝那普利和氨氯地平的标准曲线在5-60μg/
DOI:10.1016/j.Saa.2016.03.047

专利信息

专利号:US-8431712-B2
优先权日:2004-02-09
标 题 :Methods for the synthesis of pyridoxamine
发明人：KHALIFAH RAJA G; KEILITZ ROLAND; KOELLNER CHRISTOPH; DEGENHARDT THORSTEN; BRAND STEPHEN ROBERT
权利人:KHALIFAH RAJA G; KEILITZ ROLAND; KOELLNER CHRISTOPH; DEGENHARDT THORSTEN; BRAND STEPHEN ROBERT; NEPHROGENEX INC
摘要:The invention provides non-oxidative methods for the large scale manufacture of pyridoxamine (I) (4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine): n nand salts thereof.n nThe invention also provides intermediate compounds for the synthesis of pyridoxamine, as well as compositions and methods for the treatment and/or prevention of conditions associated with the formation of post-Amadori advanced glycation end-products.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-7214799-B2
优先权日:2004-02-09
标题 :Methods for the synthesis of pyridoxamine

专利号:US-2007161678-A1
优先权日:2004-02-09
标题:Methods for the synthesis of pyridoxamine

专利号:US-2005272781-A1
优先权日:2004-02-09
标 题 :Methods for the synthesis of pyridoxamine

专利号:US-4410520-A
优先权日:1981-11-09
标题 :3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
发明人：WATTHEY JEFFREY W H
权利人:CIBA GEIGY CORP
摘要:Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzaz epin-2-ones and functional derivatives are angiotension converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.