CAS: 847-83-6; (4-Methoxyphenyl)Diphenylmethanol

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CAS号104-92-7 对溴苯甲醚 | CAS号119-61-9 二苯甲酮 | CAS号611-94-9 4-甲氧基二苯甲酮 | CAS号108-86-1 溴苯 | CAS号13139-86-1 4-甲氧基苯基溴化镁 | CAS号76-84-6 三苯基甲醇 | CAS号90774-84-8 Ethanone, 2-(4-... | CAS号37964-77-5 (4-methoxy-phen... | CAS号15658-11-4 (4-羟苯基)二苯基甲醇 | CAS号611-94-9 4-甲氧基二苯甲酮 | CAS号119-61-9 二苯甲酮 | CAS号92-52-4 联苯 | CAS号613-37-6 4-甲氧基联苯 | CAS号111-27-3 正己醇 | CAS号14470-28-1 4-甲氧基氯化三苯甲烷 | CAS号177582-20-6 S-4-甲氧基苯甲基-L-半胱氨酸 | CAS号15658-11-4 (4-羟苯基)二苯基甲醇 | CAS号13865-56-0 1-benzhydryl-4-...

📜三苯基甲醇置于palladium Diacetate,Caesium Carbonate,三环己基膦体系中,用 邻二甲苯 作为反应溶剂,化学反应生成 4-甲氧基三苯代甲基醇
参考文献:钯催化的α,α-二取代的芳基甲醇的芳基化反应,是通过cc或ch键的裂解来实现的.
标题:钯催化的α,α-二取代的芳基甲醇的芳基化反应,是通过cc或ch键的裂解来实现的.
摘要:钯催化的α,α-二取代的芳基甲醇与芳基卤化物的芳基化反应不仅通过邻位的ch键裂解,还通过sp(2)-Sp(3)cc键的裂解以及酮的释放而进行(β-碳消除)得到相应的联芳基.这两个反应似乎都是通过常见的芳基钯(II)醇盐中间体发生的.报道了关于在芳基化中优先裂解cc或ch键的系统研究的结果.在重要发现中,由于空间原因,甚至可以从芳基(二苯基)甲醇中选择性除去邻位取代的芳基.因此,通过用芳基溴化物和氯化物处理相应的芳基(二苯基或二甲基)甲醇,可以有效地生产具有邻取代基的各种联芳基.
DOI:10.1021/jo0344034

专利信息

专利号:US-5512701-A
优先权日:1995-06-07
标题:Process for the synthesis of vinyl sulfenic acid derivatives
发明人：HOARD DAVID W; LUKE WAYNE D
权利人:LILLY CO ELI
摘要:The present invention is directed to a new process for the synthesis of vinyl sulfenic acid derivatives. These compounds are useful for the synthesis of benzo[b]thiophenes, in particular 2-aryl-benzo[b]thiophenes.

专利号:US-6372945-B1
优先权日:1995-06-07
标 题 :Process for the synthesis of vinyl sulfoxides
发明人：AIKINS JAMES A; MILLER RANDAL SCOT; ZHANG TONY Y
权利人:LILLY CO ELI
摘要:The present invention is directed to a new process for the synthesis of vinyl sulfoxides, in particular diarylvinyl sulfoxides

专利号:US-5606076-A
优先权日:1995-06-07
标 题 :Process for the synthesis of benzo[b]thiophenes
发明人：AIKINS JAMES A; ZHANG TONY Y
权利人:LILLY CO ELI
摘要:The present invention is directed to a process for the synthesis of 2-arylbenzo[b]thiophenes.

专利号:US-5569772-A
优先权日:1995-06-07
标 题:Process for the synthesis of benzo[b]thiophenes
发明人：HOARD DAVID W; LUKE WAYNE D
权利人:LILLY CO ELI
摘要:The present invention is directed to a new process for the synthesis of 2-aryl benzo[b]thiophenes, and to novel intermediates therefor.

专利号:US-5606075-A
优先权日:1995-06-07
标 题:Process for the synthesis of benzo[b]thiophenes
发明人：HOARD DAVID W; LUKE WAYNE D
权利人:LILLY CO ELI
摘要:The present invention is directed to new processes for the synthesis of 2-aryl benzo[b]thiophenes.

专利号:US-6448058-B1
优先权日:1997-09-12
标 题:Methods for solid phase synthesis of mercapto compounds and derivatives, combinatorial libraries thereof and compositions obtained thereby
发明人：PATEL DINESH V; NGU KHEHYONG; ZHOU JIANPING
权利人:VERSICOR INC
摘要:Methods of preparing combinatorial libraries of mercapto (thiol) compounds them and compositions obtained therefrom are disclosed. The compounds are synthesized on a solid support. Following synthesis, the compounds are optionally cleaved from the support. One such method of synthesis involves attack of an S-protected nucleophile on a resin functionalized with a leaving group. The invention also provides for screening the mercapto compounds for bioactive compounds; in particular, for inhibitors of MMPs.