CAS: 843-55-0; 1,1-Bis(4-Hydroxyphenyl)Cyclohexane

该化合物是一种双酚衍生物,用作高性能聚合物中的单体,其环二氨基二醇结构与传统双酚(如BPA)相比,增强了热稳定性和化学抗药性.BPZ在聚碳酸酯和环氧树脂配方中特别具有价值,在高温下可提高机械强度和耐久性.BPZ的雌激素活性减少使其在需要降低内分泌干扰风险的应用中成为潜在的替代物.BPZ与各种合成工艺的兼容性允许有针对性的物质特性,使之适合先进的工业,汽车和电子应用.处理要求苯酚化合物的标准安全防范措施.

结构式图片

欧盟法规

ECHA物质C&L通报DrinkingWaterDirectiveREACH预注册RSIM_DWD_INVENTORY

上下游产品

cyclohexanone phenol 1-chlor°Cyclohexene hydrogenchloride 1,1'-bis(3,5-dichloro-4-hydroxyphenyl)cyclohexane [1,1';1',1'']tercyclohexane-4,4''-diol 1,1-bis-(4-benzoyloxy-phenyl)-cyclohexane cyclohexanol

合成工艺路线路线简述

  • 合成目标产物 4,4'-Cyclohexylidenebisphenol 主要起始原料 Cyclohexanone And Phenol
  • 94385-18-9 = 843-55-0
    反应条件:1.1 Catalysts: Palladium,Carbon2.1 Reagents: Hydrochloric Acid
    标题:Method For Synthesis Of 4-Methyl-4'-Hydroxybiphenyl
    作者:Brilev,V. V.; Et Al
    参考文献:Vestsi Natsyyanal'Nai Akademii Navuk Belarusi 日期:2000 卷标:(2) 页码:72-75]

    = 843-55-0
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 48 H,70 °C
    标题:Synthesis And Reproductive Toxicity Of Bisphenol A Analogs With Cyclic Side Chains In Caenorhabditis Elegans
    作者:Roberts,Andrew H.; Et Al
    参考文献:Toxicology And Industrial Health 日期:2022 卷标:38(10) 页码:665-674]

    = 843-55-0 + 23783-62-2 + 6531-86-8 + 92-51-3 + 56025-96-8 + 108-93-0
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Water; 200 Min,4 Mpa,473 K
    标题:Aqueous Phase Hydroalkylation And Hydrodeoxygenation Of Phenol By Dual Functional Catalysts Comprised Of Pd/c And H/la-Bea
    作者:Zhao,Chen; Et Al
    参考文献:Acs Catalysis 日期:2012 卷标:2(12) 页码:2714-2723
1-氯环己烯,苯酚 反应生成 双酚z
参考文献:Production Of Bis (Hydroxyphenyl) Compounds
标题:Production Of Bis (Hydroxyphenyl) Compounds

海关参考信息

专利信息


专利号:US-2003130433-A1
优先权日:2001-10-30
标题 :Process for the production of graft polymers
发明人:WENZ ECKHARD; BUCHHOLZ VERA; EICHENAUER HERBERT; WOLF UDO; BORN RALF-JURGEN; JANSEN ULRICH; DIETZ WOLFGANG
摘要:A process of preparing a graft polymer (e.g., an ABS graft copolymer), which involves determining the concentration of at least one reaction component during the course of the reaction by means of Raman spectroscopy, is disclosed. The process, more particularly, comprises: (a) synthesizing the graft polymer from a reaction mixture comprising reactive components (e.g., monomers such as styrene and acrylonitrile, and a graft base); (b) analyzing the reaction mixture, at intervals, during the synthesis of the graft polymer, by means of Raman spectra; (c) recording the results of the Raman spectra analysis; (d) determining the concentration of at least one of said reactive components (e.g., styrene) by means of spectral evaluation of the recorded Raman spectra; and (e) terminating the synthesis reaction of the graft polymer when the concentration of at least one of the reactive components has reached a predetermined concentration value.

专利号:US-2009043069-A1
优先权日:2007-08-06
标 题 :Activated esters for synthesis of sulfonated telechelic polycarbonates
发明人:BRUNELLE DANIEL J; COLONNA MARTINO; FIORINI MAURIZIO; BERTI CORRADO; BINASSI ENRICO
权利人:GEN ELECTRIC
摘要:A process of making a sulfonated telechelic polycarbonate is described. A dihydroxy compound, a carbonate ester, and an activated ester of a sulfobenzoic acid salt are reacted together. The method results in a sulfonated telechelic polycarbonate which has a high percentage of sulfonated end groups, is soluble, and is transparent.

专利号:US-7345203-B1
优先权日:2006-11-28
标题:Cost effective method for synthesis of triarylamine compounds from an aniline and an arylchloride
发明人:BENDER TIMOTHY P; COGGAN JENNIFER A
权利人:XEROX CORP
摘要:A process for forming a triarylamine compound, including reacting an aniline and an arylchloride in the presence of a ligated palladium catalyst and a base.

专利号:US-6482977-B1
优先权日:2000-07-28
标 题:Melt process for the synthesis of diaryl esters of aliphatic diacids
发明人:WHITNEY JOHN MORGAN; FABER REIN MOLLERUS; BOVEN GEERT; LENS JAN-PLEUN
权利人:GEN ELECTRIC
摘要:This invention relates to a method for preparing diaryl esters, comprising the step of reacting a mixture comprising diaryl carbonate and a dicarboxylic acid, wherein 2.005 to 2.2 molar equivalents of diaryl carbonate per molar equivalent of dicarboxylic acid are provided.

专利号:US-6545187-B1
优先权日:2001-09-19
标 题 :Production of low-particulate bisphenol and use thereof in the manufacturing of polycarbonate
发明人:KISSINGER GAYLORD MICHAEL; CHEN FANG CHRISTINE; BLUBAUGH JAMES CRISTOPHER; NANCE DARLENE HOPE; STOKES EDWARD BRITTAIN; ORDONEZ JUAN RODRIGUEZ; QUINTANA JOSE M
权利人:GEN ELECTRIC
摘要:Low-particulate dihydric aromatic compounds such as bisphenol-A that can be used in the synthesis of low-particulate polycarbonates are prepared by introducing into a desorber column containing a non-aggregate packing material an adduct of bisphenol and phenol and optionally a stripping gas. The column is maintained at an operating temperature that is sufficiently high and an operating pressure that is sufficiently low such that the adduct is distilled. The stream of phenol and the stripping gas is recovered from the top of the column. A second stream containing bisphenol that is substantially free of added particulate matter is recovered from the bottom of the column. This purified stream of bisphenol-A can further be used in a method of producing optical-grade polycarbonate.

专利号:EP-0821042-A3
优先权日:1996-07-26
标 题:Elastic auto-crosslinking binder for coating of cans and sheets, its production and use
发明人:NEUMANN UWE DR; OBERRESSL PAUL
权利人:HOECHST AG
摘要:(1) Synthese eines Polyesters (A1) mit freien Säuregruppen aus mehrbasigen Carbonsäurenn(A11) ausgewählt aus aliphatischen Polycarbonsäuren (A111) und aromatischen Polycarbonsäurenn(A112) und Polyolen (A12), und (2) Umsetzen des Polyesters (A1) mit einem Epoxidharz (A2), nwobei die Stoffmenge der Epoxidgruppen in (A2) größer ist als die Stoffmenge der Carboxylgruppennin (A1), und der Polyester (B) wie der Polyester (A1) aus mehrbasigen Carbonsäurenn(A11) ausgewählt aus aliphatischen Polycarbonsäuren (A111) und aromatischen Polycarbonsäurenn(A112) und aliphatischen Polyolen (A12) durch Polykondensation hergestellt wird.Elastic, self-crosslinking binder, obtainable by mixing a polyester-modified epoxy resin (A) and an acid group-containing polyester (B), the epoxy resin (A) being produced in two steps (1) Synthesis of a polyester (A1) with free acid groups from polybasic carboxylic acids (A11) selected from aliphatic polycarboxylic acids (A111) and aromatic polycarboxylic acids (A112) and polyols (A12), and (2) reacting the polyester (A1) with an epoxy resin (A2), wherein the amount of the epoxy groups in (A2) is greater than the amount of the carboxyl groups in (A1), and the polyester (B) and the polyester (A1) from polybasic carboxylic acids (A11) selected from aliphatic polycarboxylic acids (A111) and aromatic polycarboxylic acids ( A112) and aliphatic polyols (A12) is produced by polycondensation.
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主要参考文献

[参考文献]: Eriko Yamazaki, Et Al. Bisphenol A And Other Bisphenol Analogues Including Bps And Bpf In Surface Water Samples From Japan, China, Korea And India. Ecotoxicol Environ Saf. 2015 Dec:122:565-72.
[参考文献]: Jorge Regueiro, Et Al. Derivatization Of Bisphenol A And Its Analogues With Pyridine-3-Sulfonyl Chloride: Multivariate Optimization And Fragmentation Patterns By Liquid Chromatography/orbitrap Mass Spectrometry. Rapid Commun Mass Spectrom. 2015 Aug 30;29(16):1473-84.
[参考文献]: Jorge Regueiro, Et Al. Determination Of Bisphenols In Beverages By Mixed-Mode Solid-Phase Extraction And Liquid Chromatography Coupled To Tandem Mass Spectrometry. J Chromatogr A. 2015 Nov 27:1422:230-238.
[参考文献]: Katra Kolek, Et Al. Screening Of Bisphenol A, Triclosan And Paraben Analogues As Modulators Of The Glucocorticoid And Androgen Receptor Activities. Toxicol In Vitro. 2015 Feb;29(1):8-15.
[参考文献]: Martin Fischnaller, Et Al. A Simple Method For The Enrichment Of Bisphenols Using Boron Nitride. Food Chem. 2016 Mar 1:194:149-55.

合成参考文献


摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
参考文献:10.1016/j.chembiol.2014.03.013
摘要:Stossi F, Bolt MJ, Ashcroft FJ, Lamerdin JE, Melnick JS, Powell RT, Dandekar RD, Mancini MG, Walker CL, Westwick JK, Mancini MA. Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays. Chem Biol. 2014 Jun 19;21(6):743–53.
参考文献:10.1016/j.chroma.2015.08.037
摘要:Regueiro J, Wenzl T. Development and validation of a stable-isotope dilution liquid chromatography-tandem mass spectrometry method for the determination of bisphenols in ready-made meals. J Chromatogr A. 2015 Oct 02;1414():110–21. doi: 10.1016/j.chroma.2015.08.037.
参考文献:10.1016/j.tiv.2017.02.004
摘要:Lee S, Kim C, Youn H, Choi K. Thyroid hormone disrupting potentials of bisphenol A and its analogues - in vitro comparison study employing rat pituitary (GH3) and thyroid follicular (FRTL-5) cells. Toxicol In Vitro. 2017 Apr;40():297–304. doi: 10.1016/j.tiv.2017.02.004.
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