CAS: 683-08-9; Diethyl Methylphosphonate

上下游产品

sodium diethyl phosphite dimethyl sulfate methanol triethyl phosphite((E)-4-Phenyl-but-3-enyl)-phosphonic acid diethyl ester (2-Hydroxy-2,2-diphenyl-ethyl)-phosphonic acid diethyl ester diethyl (2-oxobutyl)phosphonate oxo-2 phenyl-4 butenyl-3,4 phosphonate de diethyle

对甲苯磺酰氧甲基膦酸二乙酯置于sodium Tetrahydroborate,三乙基硼,三丁基氯化锡,Sodium Iodide体系中,用 正己烷,丙酮,甲苯 作为反应溶剂,化学反应生成 甲基膦酸二乙酯
参考文献:用于利用1-的cc键形成一种新的,有效的方法,2-和3-膦酰基取代从iodoalkylphosphonates衍生的基团和ñ-Bu 3 Snh / Et 3乙/ O 2系统
标题:用于利用1-的cc键形成一种新的,有效的方法,2-和3-膦酰基取代从iodoalkylphosphonates衍生的基团和ñ-Bu 3 Snh / Et 3乙/ O 2系统
摘要:描述了利用衍生自碘代烷基膦酸酯的1-,2-和3-膦酰基取代的基团和催化或化学计量的n-Bu 3 Snh / Et 3 B / O 2试剂体系的新型,实用的高取代膦酸酯的合成方法.
DOI:10.1016/s0040-4020(97)00405-5

专利信息

专利号:US-2015099864-A1
优先权日:2013-10-08
标题:Preparation of organophosphate peptide adducts
发明人：BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.

专利号:WO-2015053980-A1
优先权日:2013-10-08
标 题 :Preparation of organophosphate peptide adducts
发明人：BREWER BOBBY N; LUCAS ERIC A; BURKITT NATHAN T
权利人:BATTELLE MEMORIAL INSTITUTE
摘要:Disclosed are methods for the synthesis of organophosphorus-adducted peptides. Such peptides may be useful as biomarkers of organophosphate exposure, or for the synthesis of antibodies. Also disclosed are peptide adducts including peptide adducts of tabun, and aged adducts.

专利号:US-6608196-B2
优先权日:2001-05-03
标题 :Process for solid supported synthesis of pyruvate-derived compounds
发明人：WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L
权利人:GALILEO PHARMACEUTICALS INC
摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

专利号:WO-9815532-A1
优先权日:1996-10-09
标 题:Solid phase synthesis of heterocyclic compounds
发明人：MARZINZIK ANDREAS; FELDER EDUARD
权利人:CIBA GEIGY AG; MARZINZIK ANDREAS; FELDER EDUARD
摘要:Here we report a study on a reaction sequence on solid phase, suitable for the generation of molecular diversity on small heterocycles. For each reaction, suitable conditions on solid phase were worked out and a variety of reactive agents (building blocks) was utilized in an effort to grasp the system's breadth of applicability. The inventive reaction sequence can be applied, for example, to exploit by the combinatorial approaches of the split and mix concept. The reaction sequence comprises the following steps: a) a solid carrier having reactive surface groups is loaded directly or via a spacer group with a compound bearing an aldehyde or a methylketon function, b) said function is modified using the Witting reaction or the aldol condensation, c) the heterocyclic ring is closed using a compound comprising two nucleophiles, wherein at least one of the said nucleophiles is NH2.

专利号:US-8445695-B2
优先权日:2003-10-31
标 题 :Synthesis of phosphono-substituted porphyrin compounds for attachment to metal oxide surfaces
发明人：LINDSEY JONATHAN S; LOEWE ROBERT S; MUTHUKUMARAN KANNAN; AMBROISE AROUNAGUIRY
权利人:LINDSEY JONATHAN S; LOEWE ROBERT S; MUTHUKUMARAN KANNAN; AMBROISE AROUNAGUIRY; UNIV NORTH CAROLINA STATE; ZETTACORE INC
摘要:A method of making a phosphono-substituted dipyrromethane comprises reacting an aldehyde or acetal having at least one phosphono group substituted thereon with pyrrole to produce a phosphono-substituted dipyrromethane; and wherein the phosphono is selected from the group consisting of dialkyl phosphono, diaryl phosphono, and dialkylaryl phosphono. Additional methods, intermediates and products are also described.

专利号:US-6593347-B2
优先权日:1998-10-30
标题 :Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：BANDARAGE UPUL K; DONG QING; FANG XINQIN; GARVEY DAVID S; MERCER GREGORY J; RICHARDSON STEWART K; SCHROEDER JOSEPH D; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.