CAS: 621-88-5; 2-Phenoxyacetamide

上下游产品

CAS号122-59-8 苯氧乙酸 | CAS号3598-14-9 苯氧基乙腈 | CAS号79-07-2 氯乙酰胺 | CAS号108-95-2 苯酚 | CAS号2555-49-9 苯氧乙酸乙酯 | CAS号144-48-9 碘代乙酰胺 | CAS号701-99-5 苯氧基乙酰氯 | CAS号14316-61-1 苯氧基乙酸酐 | CAS号110009-60-4 1-(phenoxyacety... | CAS号3598-14-9 苯氧基乙腈 | CAS号1982-42-9 (2,4-二氯苯氧基)乙酰胺 | CAS号35370-80-0 2-苯氧基硫代乙酰胺 | CAS号2555-49-9 苯氧乙酸乙酯 | CAS号10397-59-8 N,N-dimethyl-2-... | CAS号122-59-8 苯氧乙酸 | CAS号3598-10-5 4-Chlorophenoxy... | CAS号2065-23-8 苯氧乙酸甲酯 | CAS号1758-46-9 2-苯氧基乙胺 | CAS号69986-21-6 4-氨基甲酰甲氧基-苯磺酰氯

苯氧乙酸置于四氯化钛,氨基甲酸铵体系中,用 甲苯 作为反应溶剂,化学反应 24.0H,以91%的收率获得产物苯氧乙酰胺
参考文献:使用氨基甲酸酯类作为胺源,由未活化的羧酸直接催化形成伯酰胺和叔酰胺
标题:使用氨基甲酸酯类作为胺源,由未活化的羧酸直接催化形成伯酰胺和叔酰胺
摘要:操作简便的钛(iv)或锆(iv)催化的非活化羧酸与氨基甲酸铵的直接酰胺化反应可反应生成伯,叔n,N-二甲基取代的酰胺,产率高至优异.
DOI:10.1002/adsc.201200436

专利信息

专利号:US-5824801-A
优先权日:1996-01-19
标 题:Process for sterospecific synthesis of keto-enol tautomeric mixture of p nitrobenzyl (1R, 6R, 7R)-7-phenoxyacetamido-3-oxo-3-cepham-4-(R/S)-carboxylate-1-oxide and p-nitrobenzyl (1R, 6R, 7R)-7-phenoxyacteamido-3-hydroxy-3-cephem-4-carboxylate-1-oxide
发明人：GUPTA NIRANJAN LAL; SANKARAN RAMANATHAN; CHATTEJEE SUGATA; KRISHNA TUMMA HARI
权利人:LUPIN LAB LTD
摘要:A process for the stereospecific synthesis of keto-enol tautomeric mixture of p-nitrobenzyl (1R,6R,7R)-7-phenoxyacetamido-3-oxo-3-cepham-4-(R/S)-carboxylate-1-oxide and p-nitrobenzyl (1R,6R,7R)-7-phenoxyacetamido-3-hydroxy-3-cephem-4-carboxylate-1-oxide is described. These compounds are valuable intermediates for the synthesis of cephalosporin antibiotics e.g. cefaclor.

专利号:US-2005119332-A1
优先权日:1998-03-12
标 题 :Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases)
发明人：JEPPESEN LONE; ANDERSEN HENRIK S; OLSEN OLE H; JUDGE LUKE M; HOLSWORTH DANIEL D; BAKIR FARID; AXE FRANK U; GE YU
摘要:The present invention provides novel compounds of formula 1a, n nnovel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:EP-1105359-B1
优先权日:1998-08-21
标 题:Solid phase synthesis of compounds by carbon-carbon bond forming mitsunobu reactions
发明人：CHATURVEDI SURENDRAKUMAR
权利人:PE CORP NY
摘要:Processes are provided for the Mitsunobu alkylation reaction of carbon-carbon bond formation between a solid support reagent and a reagent in solution. The resulting novel products can be prepared as a combinatorial library by high-throughput, parallel synthesis under robotic automation. Cleaved or support-bound products are useful precursors to biologically active compounds.

专利号:US-8470987-B2
优先权日:2009-09-16
标题:Protective group for synthesis of RNA and derivative
发明人：WADA TAKESHI; SHIMIZU MAMORU
权利人:WADA TAKESHI; SHIMIZU MAMORU; CHIRALGEN LTD
摘要:A protective group represented by the following general formula (I) (the oxygen atom attached with * represents oxygen atom of 2′-hydroxyl group of a ribonucleoside, a ribonucleotide or a derivative thereof; R 1 and R 2 both represent hydrogen atom, or represent a halogen atom, a C 1-6 alkyl group, or a C 1-6 halo-substituted alkyl group; R 3 and R 4 represent hydrogen atom, a halogen atom, a C 1-6 alkyl group, or a C 1-6 halo-substituted alkyl group; and R 5 and R 6 represent a halogen atom, a C 1-6 halo-substituted alkyl group, cyano group, nitro group, or the like), which is stable under the reaction conditions of the nucleic acid synthetic cycles and has little steric hindrance, and can be removed under mild conditions using fluoride ions as a base.

专利号:EP-0051234-B1
优先权日:1980-10-31
标题:A process for the production of a 2-azetidinone derivative
摘要:A new and efficient process of producing a 2-azetidinone derivative is provided, which comprises cyclizing a beta -amino acid by treating with triphenylphosphine and a heterocyclic disulfide in the presence of an alkylnitrile. The 2-azetidinone derivatives produced are useful as starting compound for synthesis of beta -lactam group antibiotics such as thienamycin and nocardicin.

专利号:US-9422232-B2
优先权日:2009-07-09
标题:Reductive release probes containing a chemoselectively cleavable α-azidoether linker and methods of use thereof
发明人：FRANZINI RAPHAEL M; KOOL ERIC TODD
权利人:FRANZINI RAPHAEL M; KOOL ERIC TODD; UNIV LELAND STANFORD JUNIOR
摘要:Probes comprising one or more selectively cleavable α-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable α-azidoether moieties. The α-azidoether moiety will undergo a Staudinger reaction with a suitable reducing agent, resulting in cleavage. The probes find use in a variety of detection assays, e.g. specific polynucleotide binding assays, polypeptide binding assays, etc. The cleavable linkers are suitable for synthetic reactions, e.g. to prepare probes of the invention; in the synthesis of cleavable peptide conjugates; and the like.